(n.) A poisonous alkaloid of bitter taste extracted from the leaves and seeds of the European yew (Taxus baccata). Called also taxia.
Example Sentences:
(1) In conclusion the effect of taxine on the heart results from its ICa and INa inhibiting properties similar to those of other antiarrhythmic drugs.
(2) Oxidant production was used as an indicator of inflammatory cell reactions and was measured by luminol-amplified chemiluminescence after treatment with inflammatory activators including bacteria, the neutrophil taxin formyl-Met-Leu-Phe, the Ca2+ ionophore A23187, the detergent saponin, and the tumor promoter phorbol ester.
(3) Four prisoners drank a decoction of yew (Taxus baccata) needles containing the toxic alkaloid taxine++ B.
(4) The effects of the sulfate salt of taxine, the alkaloid mixture of the yew (Taxus baccata L.), on membrane currents of enzymatically isolated single ventricular cells of guinea pig were studied under current- or voltage clamp conditions.
(5) The acute toxicity of taxine isolated from leaves of yew trees was determined in mice and rats.
(6) Under the influence of taxine, inconsistent effects were observed on the potassium outward current.
(7) Recovery from the effects of taxine is partially possible.
(8) A reliable and recognized method for the detection of taxins is required.
(9) A case of fatal taxine poisoning from the ingestion of yew leaves by a young college man is reported.
(10) A synergism of the toxic effects of taxine++ B, digitalis glycosides and hypokalemia is considered very likely.
Toxine
Definition:
(n.) A poisonous product formed by pathogenic bacteria, as a toxic proteid or poisonous ptomaine.
Example Sentences:
(1) Nutritional factors or environmental toxins have important effects on CNS degenerative changes.
(2) Arteries treated with atrial natriuretic peptide showed no alterations in relaxation or cGMP content after incubation with pertussis toxin.
(3) The mechanism by which pertussis toxin (PT) breaks the unresponsiveness of delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) was examined in B10 mice.
(4) Cloned genes encoding pertussis toxin from B. pertussis were transferred into Bordetella bronchiseptica and Bordetella parapertussis by conjugation.
(5) Strains 1120-A-83-013 and B205BT produced considerably higher levels of dermonecrotic toxin activity than did strains CSU-P-1 and 64-C-0406.
(6) The phosphorylation pattern was affected by the addition of cholera toxin or GDP beta S to the isolated nuclei.
(7) Histopathological studies confirmed that mice fed 933cu-rev died from bilateral renal cortical tubular necrosis consistent with toxic insult, perhaps due to Shiga-like toxins.
(8) Cholera toxin-catalysed ADP-ribosylation identified two forms of Gs alpha-subunits whose labelling was about 4-fold greater in membranes from diabetic animals compared with those from lean animals.
(9) The slope of the thermal inactivation curve of enterotoxin A in beef bouillon (initial pH 6.2) was found to be approximately 27.8 C (50 F) with three different concentrations of toxin.
(10) The antibodies were used for identifying cross-reacting proteins in individual C. s. scutulatus and other Crotalus venoms and to isolate Mojave toxin.
(11) Antisera were raised against intact crotoxin (Crotalus durissus terrificus), Mojave toxin (Crotalus scutulatus scutulatus) and concolor toxin (Crotalus viridis concolor), as well as the subunits of crotoxin.
(12) Interestingly, different mechanisms of nucleated and non-nucleated TC directed lysis by CD4+ effectors were implied by distinct patterns of sensitivity to cholera toxin (CT) and cyclosporin A (CsA).
(13) The second step occurs several hours later and consists of the transactivation of adenylate cyclase and pertussis toxin genes.
(14) The toxins preferentially attenuate a slow phase of KCl-evoked glutamate release which may be associated with synaptic vesicle mobilization.
(15) Bordetella pertussis and Bacillus anthracis, two taxonomically distinct bacteria, secrete adenylate cyclase toxins that are activated by the eukaryotic protein calmodulin.
(16) Approximately a third of patients had stools that were positive for C difficile by either toxin or culture.
(17) The binding of radioidinated cholera toxin on its solidified antibody was inhibitable by unlabeled cholera toxin and cholera toxin antibody.
(18) To facilitate detoxification, the centrifuge is employed to provide plasma rich in toxins, but void of potentially interfering blood components such as platelets and whole blood cells.
(19) The toxins all create pores in the cell membrane of target cells leading to eventual cell lysis and they appear to require Ca2+ for cytotoxic activity.
(20) A state of net secretory fluid flux was induced in isolated jejunal loops in weanling pigs by adding theophylline or cholera toxin to the lumen of the isolated loops.