(n.) The Roman divinity who presided over boundaries, whose statue was properly a short pillar terminating in the bust of a man, woman, satyr, or the like, but often merely a post or stone stuck in the ground on a boundary line.
(n.) Hence, any post or stone marking a boundary; a term. See Term, 8.
(n.) Either end of a railroad line; also, the station house, or the town or city, at that place.
Example Sentences:
(1) Conditions for limited digestion of the heterodimer by subtilisin, removing only the carboxyl terminus, were determined.
(2) The elongation of helix III with the addition of helix II at the N-terminus somewhat stabilizes the ordered structure.
(3) Synthetic DNA corresponding to the hydrophobic domain of cytochrome b5 was enzymatically fused in-frame to cloned DNA corresponding to the C-terminus of the Escherichia coli enzyme, beta-galactosidase.
(4) TCR beta chain gene expression of individual T cell clones that share the same MHC class II restriction and similar fine specificity for the encephalitogenic NH2 terminus of the autoantigen myelin basic protein (MBP) has been examined.
(5) When these sequences were fused to the N terminus of yeast cytochrome oxidase subunit IV lacking its own presequence, they directed the attached subunit IV to its correct intramitochondrial location in vivo.
(6) Both proteins appeared to be recognized by antibodies against the amino (N) terminus of the alpha 1 subunit sequence.
(7) These plasmin-cleaved peptides are derived from the COOH terminus of C2b, and they induce the contraction of estrous rat uterus.
(8) From the decreased alignment at the N-terminus and the presence of additional residues compared with bacterial phosphorylases, we conclude that the regulatory sequences that also carry the phosphorylation site in the muscle enzyme were joined to a presumed ancestral precursor gene by gene fusion after separation of the eukaryotic and prokaryotic lines of descent.
(9) Microsequencing of the peptides resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicates that the amino terminus of the protein is disposed at or near the cytoplasmic surface of the gap junction, and that this surface also contains a protease-hypersensitive hydrophilic sequence between residues 109 and 123, presumably connecting the second and third transmembrane segments.
(10) The N-terminal sequence (15 amino acid residues) of the L-proline activating fragment obtained by trypsin treatment was identical with that of GS2, indicating that the L-proline activating site is located at the N-terminus of the native synthetase.
(11) It is suggested that a general manner of folding may be a common feature of the heterogeneous population of kappa-chains: one bridge which folds an invariable stretch of the chain, another bridge which folds a stretch that varies from protein to protein, and a bridge at the C-terminus which is the interchain link.
(12) Cysteine proteinase I cleaved peptides primarily from the C-terminal region of Tg, which contained two major hormonogenic sites, while cathepsin-B produced peptides mainly from the N-terminus, containing another major hormonogenic site.
(13) Deletions from the N terminus of LMM did not alter the solubility properties of the expressed material, but deletion of 92 residues from the C terminus caused a large increase in solubility at low ionic strength, indicating that a determinant important for interaction between LMM molecules was located in this region.
(14) Middle component particles of bean pod mottle virus (BPMV) containing small protein subunits with a cleaved C terminus were used to produce monoclonal antibodies (MAbs).
(15) We find that the NH2-terminus of PTH is rapidly degraded in situ by the liver but that both liver and especially kidney nevertheless contain low levels of NH2-terminal PTH fragments that, although not released into the blood, are large enough to be potentially active.
(16) 2) By contrast, the COOH terminus is an inhibitory regulator of mitogenesis, and removal of the terminal 43 amino acids converts the receptor from a moderately active growth signaler to a very active one.
(17) Since the HPV-16 E6-promoted degradation involves the ubiquitin-dependent proteolysis pathway, specific mutations were made in the amino terminus of p53 to examine whether the E6 targeted degradation involved the N-end rule pathway.
(18) Examination of the inhibitory effect of ATP using oligo(dA)12-18 as well as activated DNA as primers revealed that (a) ATP inhibition is not due to its addition onto a 3'-OH primer terminus ad judged by the lack of incorporation of labeled ATP, although under similar conditions incorporation of GTP can be demonstrated, (b) a consistent degree of inhibition was noted independent of primer or enzyme concentration; (c) addition of ATP to an ongoing reaction promptly reduces the rate of polymerization; (d) kinetic studies indicate a competitive (with respect to substrate deoxy triphosphate) pattern of inhibition; (e) addition of excess deoxyribotriphosphate promptly relieves the inhibition.
(19) A peptide corresponding to the COOH terminus (residues 45-65) was synthesized utilizing lysine 47 as a specific residue to conjugate to thyroglobulin as a carrier for raising antibodies in mice.
(20) Myristic acid-labeled virions contained a single radioactive protein, p10, supporting the mapping of this molecule to the amino terminus.
Up
Definition:
(adv.) Aloft; on high; in a direction contrary to that of gravity; toward or in a higher place or position; above; -- the opposite of down.
(adv.) From a lower to a higher position, literally or figuratively; as, from a recumbent or sitting position; from the mouth, toward the source, of a river; from a dependent or inferior condition; from concealment; from younger age; from a quiet state, or the like; -- used with verbs of motion expressed or implied.
(adv.) In a higher place or position, literally or figuratively; in the state of having arisen; in an upright, or nearly upright, position; standing; mounted on a horse; in a condition of elevation, prominence, advance, proficiency, excitement, insurrection, or the like; -- used with verbs of rest, situation, condition, and the like; as, to be up on a hill; the lid of the box was up; prices are up.
(adv.) To or in a position of equal advance or equality; not short of, back of, less advanced than, away from, or the like; -- usually followed by to or with; as, to be up to the chin in water; to come up with one's companions; to come up with the enemy; to live up to engagements.
(adv.) To or in a state of completion; completely; wholly; quite; as, in the phrases to eat up; to drink up; to burn up; to sum up; etc.; to shut up the eyes or the mouth; to sew up a rent.
(adv.) Aside, so as not to be in use; as, to lay up riches; put up your weapons.
(prep.) From a lower to a higher place on, upon, or along; at a higher situation upon; at the top of.
(prep.) From the coast towards the interior of, as a country; from the mouth towards the source of, as a stream; as, to journey up the country; to sail up the Hudson.
(prep.) Upon.
(n.) The state of being up or above; a state of elevation, prosperity, or the like; -- rarely occurring except in the phrase ups and downs.
(a.) Inclining up; tending or going up; upward; as, an up look; an up grade; the up train.