(n.) A painful and usually fatal disease, resulting generally from a wound, and having as its principal symptom persistent spasm of the voluntary muscles. When the muscles of the lower jaw are affected, it is called locked-jaw, or lickjaw, and it takes various names from the various incurvations of the body resulting from the spasm.
(n.) That condition of a muscle in which it is in a state of continued vibratory contraction, as when stimulated by a series of induction shocks.
Example Sentences:
(1) Twitch-tetanus ratios were calculated and found not to be related to unit contraction time.6.
(2) The combination vaccine consisted of 12 Lf tetanus toxoid and 10 TCID50 vaccinia virus "MVA" preserved with gelatine and glucosamine.
(3) An analysis of 249 cases of neontal tetanus admitted to Korle-Bu Teaching Hospital, Accra, between January 1971 and December 1974, has been presented.
(4) The stiffness of the fibre first rose abruptly in response to stretch and then started to decrease linearly while the stretch went on; after the completion of stretch the stiffness decreased towards a steady value which was equal to that during the isometric tetanus at the same sarcomere length, indicating that the enhancement of isometric force is associated with decreased stiffness.
(5) Between 1974 and 1984, 418 patients with tetanus, aged 10 years and older, represented 64.8% of all admissions to the intensive care unit of the Lagos University Teaching Hospital.
(6) Neither the two-chain forms of botulinum A toxin and tetanus toxin, under reducing conditions, nor the light chains of tetanus toxin, inhibited amylase release triggered by Ca2+, or combinations of Ca2+ + GTP[S] or Ca2+ + cAMP.
(7) The only significant change found was in the radioactivity of the 18,000-dalton light chain of myosin; during a single tetanus, an increase of 85 to 90% occurred as compared to the resting muscle.
(8) In this report, we describe the successful generation of triomas secreting HuMAbs to tetanus toxin (tt).
(9) In DA-depleted slices, LTD could be restored by applying exogenous DA (30 microM) before the conditioning tetanus.
(10) Different components of B. pertussis were found to have a similar inhibitory effect on thymidine-3H incorporation caused by phytohemagglutinin (PHA) in the culture of lymphocytes taken from donors immunized with tetanus toxoid.
(11) Two main polypeptides, Mr about 27,000 and 21,000, were protected against pepsin proteolysis when a mixture consisting of asolectin vesicles and 125I-labeled tetanus toxin was subjected to a pH drop from 7.2 to 3.0.
(12) Enzyme-linked immunosorbent assay (ELISA) tests were developed to detect IgG antibodies to diphtheria, tetanus, and pertussis in a healthy New Zealand population.
(13) The tetanus antitoxin titers of blood obtained by venepuncture and those of finger-blood absorbed on filter paper are compared when the titration techniques use fresh or formalinized erythrocytes sensitized by the bis-diazotized benzidine (BDB) method.
(14) Because previous studies assumed that tetanus is an acetylcholine intoxication, atropine as a potent anticholinergic agent has been employed as a continuous infusion in the treatment of 4 severe tetanus cases as a supplement to routine therapy.
(15) Secondary structure contents of tetanus neurotoxin have been estimated at neutral and acidic pH using circular dichroism (CD) and Fourier transform infrared (FT-IR) spectroscopy.
(16) In regular medicine if a patient goes to a doctor to be treated for a rat bite, the physician cleans the bite, dresses it, gives antibiotics, and gives a tetanus shot.
(17) These findings are in accordance with the immunization programme followed for prophylaxis against tetanus among pregnant women.
(18) AMP aminohydrolase activity is enhanced by 60% after 5 s tetanic stimulation of phosphorylase kinase-deficient mouse muscle and after 60 s tetanus in normal mice.
(19) Fragment C is a non-toxic 50 kDa fragment of tetanus toxin which is a candidate subunit vaccine against tetanus.
(20) Data are presented to show that the adoption of such methods would increase the information available from each animal and so reduce the number of animals required for the satisfactory standardization of diphtheria and tetanus vaccines.
Tetany
Definition:
(n.) A morbid condition resembling tetanus, but distinguished from it by being less severe and having intermittent spasms.
Example Sentences:
(1) It is shown from an analysis of the transient force responses observed after sudden changes in muscle length applied both at full and reduced overlap and during the rising phase of short tetani that these responses can be explained on the basis of varying numbers of cross bridges attached at the time of the length step.
(2) The existence of such an effect also in the present preparation was studied by giving 'interrupted' tetani with a total duration of about 2 s. In rested fibres the mean rate of relaxation was found to fall from 140.9 to 71.8% (n = 11) of the control (end of 350 ms stimulation) with a time constant of about 0.5 s. Thus, a marked slowing during a long tetanus occurs also in mammalian muscle.
(3) A physiological deficiency of Mg results in hypomagnesemic tetany.
(4) The investigation involved the older workers and the workers at highest dust exposure levels and included general medical screening with emphasis on the existence of hypertension, edema, calcium tetany, anemia, common skin problems, nasal septum perforation, persistent diarrhea; lung function tests; serum analyses for sulfate, calcium, sodium, and chloride content; and urinary inorganic sulfate output.
(5) This can lead to neonatal tetany or perhaps permanent neonatal hypoparathyroidism.
(6) In grass tetany, the animals generally are grazing cool-season forages in which Mg concentration or bioavailability of plant Mg is low.
(7) Immunoprophylaxis of infectious complications in surgical patients is currently practiced and is efficacious for disease caused by Clostridium tetani, rabies virus, Streptococcus pneumoniae, and hepatitis B virus.
(8) The association between idiopathic mitral valve prolapse (MVP) and latent tetany (LT) is common, as shown in our previous studies on adults and children.
(9) Renal tubular acidosis and tetany were the 1st manifestations of Kearns-Sayre syndrome in a 5-year-old child.
(10) In this case, anaerobic culture of C tetani was unsuccessful, possibly because of the inherent difficulty of anaerobic transfer from an oral locus and the extreme fastidiousness of the organism.
(11) Underlying tendency to tetany is the most common aetiology, going hand in hand with increased histamine sensitivity.
(12) Isometric responses to single and twin pulses, tetani and sinusoidal stimulation were measured.
(13) Steady-state force and [Ca2+]i were measured during tetani, and the force versus [Ca2+]i relation was obtained by varying the extracellular calcium concentration ([Ca2+]o).
(14) Further research is required before these lesions can be identified and new knowledge applied to the development of economical, effective programs that prevent milk fever and hypomagnesemic tetany.
(15) Like tetany, which was present in 12 of the patients, epilepsy was a common symptom, occurring in 13, seven of whom had received anticonvulsants for two to eight years before hypocalcaemia was detected.
(16) The results suggest that alkalosis per se can cause tetany in Bartter's syndrome.
(17) A 2-kilobase (kb) EcoI fragment of Clostridium tetani DNA was identified by Southern blotting and was cloned into the Escherichia coli plasmid vector pAT153 with the 32P-labeled oligonucleotide mixture as a probe.
(18) Thirty-eight animals were continued on treatment for a 2nd yr. Sometribove did not affect the incidence of ketosis, milk fever, tetany, or pneumonia.
(19) Although the culture filtrate was highly active, disc electrophoresis revealed that the toxin is a minor component of the mixture of proteins in the crude preparation, and that the minor representation contrasts with the relative prominence of exotoxins in cultures of other bacteria, such as Vibrio cholerae, Corynebacterium diphtheriae, and Clostridium tetani.
(20) Thus, a fetal death or an episode of neonatal tetany may reveal a maternal hyperparathyroidism.