(1) The carboxyl terminus of TIAR contains a lysosome-targeting motif, indicating that TIAR is probably a cytotoxic granule-associated protein.
(2) Although immunoblotting analysis of post-nuclear supernatants revealed TIA-1 protein to be restricted to CTLs, PCR analysis revealed the expression of TIA-1 and TIAR mRNA transcripts in a wide variety of cell types.
(3) Here we report the characterization of a cDNA encoding a TIA-1-related protein designated TIAR.
(4) The deduced amino acid sequence of TIAR reveals it to be a 42-kDa protein possessing three RNA-binding domains and a carboxyl-terminal auxiliary domain.
(5) Although the RNA-binding domains of TIA-1 and TIAR share greater than 85% amino acid homology, their carboxyl-terminal auxiliary domains are only 51% homologous.
(6) Like TIA-1, purified recombinant TIAR induced DNA fragmentation in permeabilized target cells.
Tiara
Definition:
(n.) A form of headdress worn by the ancient Persians. According to Xenophon, the royal tiara was encircled with a diadem, and was high and erect, while those of the people were flexible, or had rims turned over.
(n.) The pope's triple crown. It was at first a round, high cap, but was afterward encompassed with a crown, subsequently with a second, and finally with a third. Fig.: The papal dignity.
Example Sentences:
(1) The pieces include a barrel-shaped diamond worth at least $5m (£3.3m) and a Cartier diamond tiara estimated to be worth more than $100,000.
(2) The country’s supreme court ruled that Imelda Marcos illegally acquired the items, including diamond-studded tiaras and an extremely rare 25-carat pink diamond.
(3) Withheld documents · Sale of arms to Saudi Arabia · Special maritime surveillance operations · An improved kiloton bomb · Production of chemical weapons · Chemical warfare policy · Operations Grape and Tiara · Medical aspects of interrogation · Special operations and how they affect deception · Atomic energy: information received from US under military agreement · Nuclear warheads in the far east · Project R1 · SAS regiment: Borneo operations
(4) London's garden bridge: will 'tiara on the head of fabulous city' ever be built?
(5) Facebook Twitter Pinterest Imelda’s diamond and pearl tiara.
(6) There are also a number of files with intriguing titles such as Operation Tiara, Operation Grape, and Project R1, as well as some which contain details of supposed UFO sightings.
(7) "Billionaire fashionista" Evgeny Lebedev wore tailored his 'n' hers trouser suits with his actress girlfriend Joely Richardson to Sir Elton John's White Tie & Tiara Ball in June.
(8) Instead, take inspiration from Molly Ringwald in the most seminal prom film of all time, Pretty in Pink, in which her character spends precisely no money at all on her dress, wears a giant pink sack to the dance and ends up with her happy ending, without even a tiara.
(9) The fast-talking 61-year-old shakes hands with one wearing a tiara and sash reading “Miss Columbus”, from a beauty pageant to celebrate its namesake’s arrival in North America.
(10) This problem may prove even more curious than the case of Elton of John's tiara.
(11) Cartier International, which established its reputation in the 19th century by crafting tiaras and necklaces for royalty, declined to comment on the case.
(12) And beyond Capote's character and Hepburn's performance is the iconic image of Holly herself – with little black dress, black gloves, a tiara and a foot-long cigarette holder.
(13) The pieces include a barrel-shaped diamond worth at least $5m (£3.3m) and a Cartier diamond tiara believed to be worth more than $100,000.
(14) Clad in a "midnight-blue ceramic rainscreen", this plump cousin of the Gherkin (in which Partington also had a hand) appears to be bursting out of its corset of "white porcelain ribs", which overshoot the penthouse skybar to form a tacky tiara on the skyline.
(15) And Jonathan Reilly, along with two friends, donned tutus and tiaras, grabbed a magic wand, and went trick-or-treating … in August.
(16) What next for what Lumley called, somewhat hopefully, “the tiara on the head of our fabulous city”?
(17) #Emmys September 23, 2013 Updated at 3.19am BST 3.11am BST The Colbert Report introduces its team with an homage to NSA surveillance (and obviously gets points from us ), puppets stand-in for The Daily Show group, Oprah introduces the writers of Jimmy Kimmel Live , the Portlandia crew gets applause from a concert audience, Toddlers in Tiaras stand-in for the writers of Real Time with Bill Maher , some weird collection of SNL references for its team.
(18) Yet Snyder clearly has no problem with Wonder Woman, who owns an invisible plane and attacks enemies with her tiara, so it seems all bets are off.
(19) I picked up my departed mother’s sparkly red and green Christmas tiara and ran with it.
(20) Last year, Christie’s valued the collection; they identified treasures that had previously been missed, including a tiara with 25 pearls in a diamond frame seized from the Russian tsar’s family in the 1918 revolution.