(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.
Tighten
Definition:
(v. t.) To draw tighter; to straiten; to make more close in any manner.
Example Sentences:
(1) In a clear water reservoir built in ready construction after a working-period of five months quite a lot of slime could be found on the expansion joint filled with tightening compound on the base of Thiokol.
(2) Under pressure from many backbenchers, he has tightened planning controls on windfarms and pledged to "roll back" green subsidies on bills, leading to fears of dwindling support for the renewables industry.
(3) Since then, Republican activists and enthusiasts have been energised and polls have tightened.
(4) With the City's regulatory framework being tightened by the coalition government, which is disbanding the FSA and handing control of bank oversight to the Bank of England , there is concern in London that the US politicians are being opportunistic.
(5) We need to stop making excuses for them: But it is up to the state to close the loopholes Yes, the state must work continually to tighten and simplify the tax regime, which is a deliberate mess keeping an entire industry of accounting firms and tax lawyers fed.
(6) A simplified procedure is described whereby tissue is removed via a posterior eyelid approach so that the eyelid may be tightened both horizontally and vertically, thus inverting the punctum and fixating it in the lacrimal lake.
(7) Increased slippage torques of approximately 100 per cent were noted in all interfaces at low values of tightening torque (6 and 8 N m) of the wing-nut clamp and improvements of not less than 50 per cent were obtained at higher tightening torques (10 and 12 N m) on the wing-nut clamp.
(8) After the 2009 shooting, the US military tightened security at bases nationwide.
(9) Several procedures have been developed to restore closure of the paralyzed upper eyelid (implantation of gold weights or open wire springs) or to correct lower lid lagophthalmos and ectropion (lower lid tightening with a Bick procedure or insertion of a closed eyelid spring).
(10) Otherwise, the United States will continue to work with allies and partners to tighten national and international sanctions to impede North Korea's nuclear and missile programmes."
(11) Tightening compounds which were used in the sphere of drinking-water led to a microbial settlement that differs in points of quantity and quality depending on the kind of material.
(12) As border security has been tightened in recent years, and the flow of migrant workers has declined, routes across the border have been controlled by violent drug cartels.
(13) Emanuel has received backing from establishment Democrats and business leaders who have praised his financial acumen, including attracting new businesses and budget tightening to attempt to close a roughly $300m operating deficit.
(14) Installation of an irrigation infusion in the postoperative period and well-tightened connections help avoid such complications as thrombus formation, bleeding or air embolism.
(15) | Hugh Muir Read more Wherever Labour people gather to discuss how to break out of the vice tightening around the party, answers fail amid sighs of utter despair.
(16) Labour sources said they also wanted to make sure that the legislation was tightened up so jobseekers' regular rights of appeal, separate to the court of appeal judgment, were not also trampled on by the new law.
(17) All of this has been accompanied by ideological tightening across academia, religion, even state media and officialdom itself: a sort of sterilisation of the environment.
(18) Plans to tighten regulation of Britain's main banks will also include "living wills", which the FSA said was moving ahead quickly.
(19) Tightening of clasps already in contact with a tooth frequently produces adverse changes.
(20) They are already under pressure from their regulator, the Financial Services Authority, to tighten their lending criteria.