(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.
Uptight
Definition:
Example Sentences:
(1) He was not in the mood for elaboration, with abundant short answers and uptight reactions to the topics that were suggested for discourse.
(2) I would be flabbergasted that if anyone bothered to test the loos of some of our most uptight rightwing papers they didn't find some traces of Class A drugs.
(3) Surely the whole point of The Heat's dynamic in the first place is that Sandra Bullock's character is skinny and prissy and uptight and Melissa McCarthy's character is bigger and bolshier and her diametric opposite?
(4) Even then, I kept thinking, 'Do I have to be so uptight for so long?'
(5) Immediately before and at intervals up to four hours after drug ingestion, patients rated pain severity, pain relief, the tense and uptight feeling, and muscle stiffness.
(6) City's Mancini, following a series of nervy, half-hearted predecessors less suited to the strange, monumental and messy task of creating a football team in opposition to the extortionate Reds, and remaking history – which Ferguson understood with his own particular combative cunning – has this purpose too, this instinctive perception of how to succeed by channelling uptight regional mentality as well as introducing fresh, resourceful outside skills.
(7) Until Keith came along, people were very uptight about eating out, and he helped us to chill out about it."
(8) Based on the 007-style adventures of the eponymous heroine, the new flick will unfold in a similar vein to The Heat, which sees McCarthy's foul-mouthed Boston cop pair up with an uptight FBI agent (Sandra Bullock).
(9) 'When it comes to their bodies, women are uptight.'
(10) They have low self-esteem and confidence just because our culture teaches us to be so confined and uptight.
(11) Yes, he's bad, but he's charming to people 95% of the time, and his colleagues [in the scam] are so fun, and funny, and yet I have to be this uptight slappy-face.
(12) Due Date – from The Hangover's director, Todd Phillips – has line-for-line one of the sharpest scripts of the bunch but is almost scuppered by the sour note that crops up continually, stirred up by Robert Downey Jr 's uncharacteristically uptight performance as a dad-to-be.
(13) She is bossy, domineering, abrasive, secretive, uptight and petty – but what really gets me is her serial use of covert, sneaky methods to get what she wants – often at my expense.
(14) Everydaysexism.com has become enormously popular because women get so used to street harassment and sexism that it's become normalised and you're seen as uptight if you draw attention to it.
(15) Everyone works that effortless just-got-out-of-bed look, but they are uptight about their coffee.
(16) The woman who would have been Diana's daughter-in-law is undoubtedly experiencing many of the pressures Diana was facing, but is probably better equipped to deal with them, with a more relaxed and media-savvy sense, and what appears to be a less frantically uptight and solemn attitude than that surrounding Charles and Diana in private.
(17) "I'm sure the reason she did it was because people thought she was kind of uptight," says Batali, who has known her for 10 years.
(18) Lead actor Tatiana Maslany plays eight (and counting) cloned versions of herself, flitting seamlessly between characters including a cop, a Ukrainian sociopath, and an uptight soccer mom with a drink problem.
(19) Chamcha, the inauthentic, uptight and elitist migrant to London, constantly mocked for these qualities while in Bombay, is allowed to redeem himself, while the indigenously rooted and social-climbing villain cannot escape the deserts of his villainy.
(20) Talented and beautiful, sure, but also perceived as uptight, erudite, perhaps even royal in their dispositions.