(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.
Wight
Definition:
(n.) Weight.
(n.) A whit; a bit; a jot.
(n.) A supernatural being.
(n.) A human being; a person, either male or female; -- now used chiefly in irony or burlesque, or in humorous language.
(a.) Swift; nimble; agile; strong and active.
Example Sentences:
(1) That was incorrect: for example, the Isle of Wight has never had a female MP.
(2) The owners of a wind turbine factory on the Isle of Wight won a repossession order today in their attempt to end an occupation of the plant by workers protesting at planned job losses.
(3) Total maternal wight gain during gestation was lower for smoke-exposed animals than for non-smoke-exposed animals.
(4) Vestas has confirmed the closure of two sites on the Isle of Wight and Southampton with the loss of 425 jobs.
(5) Areas topping the league for quality beaches were the Isle of Wight, with two blue flags and 12 QCAs, Torbay, with five blue flags and nine QCAs, and Thanet, which has seven blue flags and four QCAs.
(6) Linehan is giving bigger roles to the other gangsters, not least the Teddy Boy spiv Harry, originally depicted by Peter Sellers, who will be played on stage by Stephen Wight.
(7) James Armstrong Dorchester • Here on the Isle of Wight, more than 3,000 planning applications have been approved by the council, to reach the island target of 520 houses a year, yet there is little activity on those sites.
(8) Domiciliary nebulizer use is evaluated in a well-defined population on the Isle of Wight covering all ages.
(9) According to tourist authorities on the Isle of Wight, there has been a “very significant leap” in its website traffic, while Visit East Anglia said its enquiries had risen by a quarter.
(10) But in a comparison to a fourth isle of Wight squirrel found dead last year, Simpson and other colleagues report in a letter to the journal that three had the same type of staph A, ST49, which has previously found in human isolates, according to a national database based at Imperial College, London.
(11) Sheridan told the court Wight had been one of the NoW's heaviest users of Whittamore, with Wight's name appearing about 70 times in Whittamore's records.
(12) Mr Quigley, who lives on the Isle of Wight, says: "I interpreted that as saying, 'Look for another bank account'.
(13) It was Wight who later provided a link to Astor, Davie's second and principal mentor.
(14) However, Britain currently has no commercial-scale wind turbine manufacturing plants, following the closure of the Vestas plant on the Isle of Wight last year.
(15) The company said that 40 employees had been found new roles within the Vestas research and development facility on the Isle of Wight.
(16) The setback follows the decision by the leading turbine maker Vestas to shut its Isle of Wight turbine factory this summer, just days after the government promised a clean-tech job revolution.
(17) David Wolfe QC, for the trust, claimed the two culls would involve killing an estimated 3,400 badgers in each area – each approximately the size of the Isle of Wight – and the long-term intention was to issue licences for up to 10 culls each year.
(18) I think she is the oldest person in the world to have a hip operation, and the surgeon, Jason Millington, and the anaesthetist were both courageous to take the decision to operate on someone of that age, but the operation went splendidly.” Hermiston said his mother, from Ryde, Isle of Wight, was recovering well after the operation last Friday.
(19) Since 1982, in the Isle of Wight hospitals, 13 cases of splenic injury following trauma have been treated applying various salvage procedures and are reported here.
(20) Julian Critchley: ‘Michael Gove radicalised me’ A civil servant in the Department for Education before training to be a teacher 12 years ago, Critchley last year left his job as head of history at a south London comprehensive to move to the Isle of Wight.