(1) Analysis of lymphocyte subsets by flow cytometry demonstrated Leu 4, 43.6% (T cells); Leu 10, 10.5% (B cells) and Leu 7, 13.1% (natural killer (NK) cells) in TIL.
(2) With one exception none of the purified CD4+ or CD8+ TILs expressed any significant levels of CD56, while the unseparated TILs contained varying numbers of CD3+CD56+ and CD3-CD56+ populations.
(3) Furthermore, it was also confirmed that TIL-LAK cells could be induced in autochthonous mouse tumor systems and human gastric tumor systems.
(4) However, IL-4 did not alter the cytotoxic activity of TILs against autologous tumor cells and established tumor cell lines.
(5) I'm here to defend her 'til the end even if they put me in jail."
(6) PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody.
(7) TIL grown in the presence of IL-4 significantly reduced the level of non-specific, non-major histocompatibility complex-restricted antitumor activity (P < 0.01 for allogeneic renal, nonrenal, and NK-sensitive K562 cells), while exhibiting no effect on the level of autologous killing.
(8) In contrast, immune T cells (including some TIL) are MHC-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (TNF beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell DNA fragmentation.
(9) Much has been learned about TIL biology and their functional characteristics recently, but only few clinical trials have been completed to date.
(10) Tumor-infiltrating lymphocytes (TIL) from human pulmonary tumors have been studied as a model for local depression of cell-mediated immunity at the tumor site.
(11) Phenotypic analysis of expanded TIL and two clones further analyzed in more detail showed CD3+, CD4+, CD8-, and 2H4+ (CD45R+) expression.
(12) The studies demonstrate the feasibility of TILs as suitable cellular vehicles for the introduction of therapeutic genes into patients receiving autologous TILs.
(13) High levels of activity were exhibited by TIL against both P815, which is resistant to natural killer (NK) cells, and to NK-sensitive YAC-1 cells.
(14) To improve the potency of TILs, new cytokines with T-cell stimulatory effects used alone or in combination with interleukin-2 (IL-2) are currently being investigated.
(15) On the other hand, TIL derived from the 2 patients whose melanoma cell lines had lost expression of HLA-A2 had a predominant CD4 phenotype and virtually no cytotoxic activity.
(16) These observations may imply the possibility of adoptive immunotherapy using TIL against human primary liver tumors.
(17) Titration of K562 targets in a 51Cr release assay revealed that untreated TIL have low cytotoxicity (4.32%) compared to untreated PBL (34.3%, P = less than 0.001).
(18) Dominant rearrangements of T-cell receptor (TCR) beta-chain genes are reported among tumor-infiltrating lymphocytes (TIL).
(19) This augmentation of TIL-mediated antitumor activity was dependent on the dose of radiation used.
(20) Those TIL expressing activation antigens were CD2+, SIg-.
Tile
Definition:
(v. t.) To protect from the intrusion of the uninitiated; as, to tile a Masonic lodge.
(n.) A plate, or thin piece, of baked clay, used for covering the roofs of buildings, for floors, for drains, and often for ornamental mantel works.
(n.) A small slab of marble or other material used for flooring.
(n.) A plate of metal used for roofing.
(n.) A small, flat piece of dried earth or earthenware, used to cover vessels in which metals are fused.
(n.) A draintile.
(n.) A stiff hat.
(v. t.) To cover with tiles; as, to tile a house.
(v. t.) Fig.: To cover, as if with tiles.
Example Sentences:
(1) Inside, the tiles and the stained glass are said to be perfection, matched against murals that depict the inventions of the industrial revolution and the signing of the Magna Carta.
(2) The risk of getting malaria was greater for inhabitants of the poorest type of house construction (incomplete, mud, or cadjan (palm) walls, and cadjan thatched roofs) compared to houses with complete brick and plaster walls and tiled roofs.
(3) The artist covered every inch of the steps in front of his house in tiles, ceramics and mirrors – originally in the green, yellow, blue and white of the Brazilian flag, later adding tiles in other colours brought by visitors.
(4) The infected cells treated by this method showed light green fluorescence of the protoplasm, with a dark nucleus, while the intact cells had tile-red cytoplasm.
(5) The results of these experiments demonstrated a significant superiority of this modification over the conventional techniques, particularly over the tile technique used generally in this country.
(6) The rustic rooms have clay tiles and wooden furniture, and the walls are brightened up with local fabrics.
(7) The algorithm presented has been developed to choose the tiling which minimizes the estimated error when the tile approximation of the surface is used in subsequent quantitative algorithm such as the calculation of surface area.
(8) When General Electric jobs left Schenectady so did a way of life Read more Patrignani proudly chats me through the bewildering array of silicone-based products Momentive makes and that end up in everything from lipstick, car parts and the adhesives that are used in stamps and bandages to airplane seats and the glue that held the tiles on the space shuttle.
(9) Any of the original N2 fields or composites of M adjacent tiles can be recalled to the video display for analysis.
(10) "There's so much graphic detail in some of the tiles that they seem to speak with a modern voice," adds Roberts.
(11) Tritium retention noted in graphite tiles underscores the significance of material selection in present and future 3H-fueled fusion devices.
(12) The efficacy of defibrillation using the damped sine and constant-tile (60%) truncated exponential waveforms was determined in each of nine dogs.
(13) The Glasgow Boys went after this mood with a will and set up temporary homes among the red-tiled roofs of the rural east – Cockburnspath was by no means their only base – to prospect for scenes that would do justice to an imagination fired by their heroes Corot , Millet and Bastien-Lepage.
(14) The genius of The Great British Bake Off Read more Viewers have seen contestants throw pots blindfolded, and create objects ranging from bone china chandeliers to decorated tiles and bathroom sinks.
(15) The tiles, I am told, are also Italian, the chandeliers Czech, the fridge American, the stove German.
(16) Ceramic samples such as tiles and bricks were collected from locations between 523 and 2,453 m from the hypocenter in Hiroshima and from between 731 and 1,565 m in Nagasaki.
(17) At that time X----- itself was untouched by shot and shell, the old houses in the square with their quaint red-tiled roofs, irregular as peaks of a sierra, and their higgledy-piggledy doors and windows, were as yet intact.
(18) Centro Cerámica Triana Facebook Twitter Pinterest Photograph: Alamy Housed in an old ceramics factory built on the site of a 16th-century one, inevitably plonked on a Roman one, this museum (€2pp, Calle Antillano Campos 14) could do more to trumpet the industry that spawned Triana, created the look and feel of Seville, and inspired Lisbon’s artisans to have a go at the whole tile thing.
(19) Pictures showed a large group of people lying on polished tiled flooring, most of them near to a wall and surrounded by rubble and other debris.
(20) 120 Grosvenor Street, 0161 273 1552, sandbarmanchester.co.uk Marble Arch The Marble Arch pub, Manchester It's 125 years old but this handsome Victorian boozer – all glazed tile work and vintage detail – has never been busier.