(1) Analysis of lymphocyte subsets by flow cytometry demonstrated Leu 4, 43.6% (T cells); Leu 10, 10.5% (B cells) and Leu 7, 13.1% (natural killer (NK) cells) in TIL.
(2) With one exception none of the purified CD4+ or CD8+ TILs expressed any significant levels of CD56, while the unseparated TILs contained varying numbers of CD3+CD56+ and CD3-CD56+ populations.
(3) Furthermore, it was also confirmed that TIL-LAK cells could be induced in autochthonous mouse tumor systems and human gastric tumor systems.
(4) However, IL-4 did not alter the cytotoxic activity of TILs against autologous tumor cells and established tumor cell lines.
(5) I'm here to defend her 'til the end even if they put me in jail."
(6) PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody.
(7) TIL grown in the presence of IL-4 significantly reduced the level of non-specific, non-major histocompatibility complex-restricted antitumor activity (P < 0.01 for allogeneic renal, nonrenal, and NK-sensitive K562 cells), while exhibiting no effect on the level of autologous killing.
(8) In contrast, immune T cells (including some TIL) are MHC-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (TNF beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell DNA fragmentation.
(9) Much has been learned about TIL biology and their functional characteristics recently, but only few clinical trials have been completed to date.
(10) Tumor-infiltrating lymphocytes (TIL) from human pulmonary tumors have been studied as a model for local depression of cell-mediated immunity at the tumor site.
(11) Phenotypic analysis of expanded TIL and two clones further analyzed in more detail showed CD3+, CD4+, CD8-, and 2H4+ (CD45R+) expression.
(12) The studies demonstrate the feasibility of TILs as suitable cellular vehicles for the introduction of therapeutic genes into patients receiving autologous TILs.
(13) High levels of activity were exhibited by TIL against both P815, which is resistant to natural killer (NK) cells, and to NK-sensitive YAC-1 cells.
(14) To improve the potency of TILs, new cytokines with T-cell stimulatory effects used alone or in combination with interleukin-2 (IL-2) are currently being investigated.
(15) On the other hand, TIL derived from the 2 patients whose melanoma cell lines had lost expression of HLA-A2 had a predominant CD4 phenotype and virtually no cytotoxic activity.
(16) These observations may imply the possibility of adoptive immunotherapy using TIL against human primary liver tumors.
(17) Titration of K562 targets in a 51Cr release assay revealed that untreated TIL have low cytotoxicity (4.32%) compared to untreated PBL (34.3%, P = less than 0.001).
(18) Dominant rearrangements of T-cell receptor (TCR) beta-chain genes are reported among tumor-infiltrating lymphocytes (TIL).
(19) This augmentation of TIL-mediated antitumor activity was dependent on the dose of radiation used.
(20) Those TIL expressing activation antigens were CD2+, SIg-.
Till
Definition:
(prep.) To plow and prepare for seed, and to sow, dress, raise crops from, etc., to cultivate; as, to till the earth, a field, a farm.
(n.) A vetch; a tare.
(n.) A drawer.
(n.) A tray or drawer in a chest.
(n.) A money drawer in a shop or store.
(n.) A deposit of clay, sand, and gravel, without lamination, formed in a glacier valley by means of the waters derived from the melting glaciers; -- sometimes applied to alluvium of an upper river terrace, when not laminated, and appearing as if formed in the same manner.
(n.) A kind of coarse, obdurate land.
(v. t.) To; unto; up to; as far as; until; -- now used only in respect to time, but formerly, also, of place, degree, etc., and still so used in Scotland and in parts of England and Ireland; as, I worked till four o'clock; I will wait till next week.
(conj.) As far as; up to the place or degree that; especially, up to the time that; that is, to the time specified in the sentence or clause following; until.
(prep.) To prepare; to get.
(v. i.) To cultivate land.
Example Sentences:
(1) As could be expected, objective response was seen in only a small number of patients followed up till 9 months.
(2) During heavy exercise at 65-75% of VO2 max, time till exhaustion correlates with the pre-exercise muscle glycogen concentration and exhaustion coincides with empty glycogen stores.
(3) Now cases cured till Dec. 1987 are 4640 (1120 MB + 3520 PB) 17 cases relapsed after MDT (15 PB + 2 MB).
(4) Up till now none of the available laser systems are optimal for application in the cardiovascular system, but still many of them have been effective clinically.
(5) They were till now used mainly to regulate contraception and menstrual flow.
(6) Everything on Tonight's the Night was recorded and mixed before On the Beach was started, but it was never finished or put into its complete order till later.
(7) 50 patients treated in the period from 1925 till 1977 with a spondylolisthesis of more than 50% have been reviewed.
(8) In our opinion in case of typical anamnesis the cerclage-operation is to be performed earlier than in the practice up till now, before opening the cervical os, and the infection of the amnion.
(9) Recurrent free curves were compared till 1050 days after the initiation of the study.
(10) Social workers were branded as communists and detained till they confessed, often after coercive treatment.
(11) And he says the north has been pretty underserved till now.
(12) Thus, these two species are more closely related than suggested earlier; g) Till now, no Mycobacterium has been found showing nicotinamidase without "pyrazinamidase" activity (or vice versa).
(13) The new antibody specificity is a specific serological finding in patients with Bechterew's disease and is therefore suitable for use as a diagnostic, and perhaps also as a prognostic test for this type of spondylarthritis till now assumed to be seronegative.
(14) This is the story of Emmett Till and Eric Garner, and a thousand stories in between.
(15) It was then gradually elevated from the beginning of the 1st month following excision till it reached 88% of the level before excision at the 10th month.
(16) What’s more, older people are now topping up pensions by doing a few hours a week stacking shelves or operating the tills at the supermarket.
(17) Who is going to take on these duties when the current generation will have to literally work till they drop?
(18) An endemic hospital infection caused by E. coli 0111:B4 together with Pseudomonas aeruginosa was observed in a county hospital over the period October 1973 till January 1974, which could not be brought under control by routine preventive measures against cross-infections established on the wards.
(19) The colony-forming activity of embryo lung cells CBA mice was determined according to the Till and McCulloch technique (1961).
(20) I’ve lived in rooms in attics, and I worked till I was 70.