(1) Analysis of lymphocyte subsets by flow cytometry demonstrated Leu 4, 43.6% (T cells); Leu 10, 10.5% (B cells) and Leu 7, 13.1% (natural killer (NK) cells) in TIL.
(2) With one exception none of the purified CD4+ or CD8+ TILs expressed any significant levels of CD56, while the unseparated TILs contained varying numbers of CD3+CD56+ and CD3-CD56+ populations.
(3) Furthermore, it was also confirmed that TIL-LAK cells could be induced in autochthonous mouse tumor systems and human gastric tumor systems.
(4) However, IL-4 did not alter the cytotoxic activity of TILs against autologous tumor cells and established tumor cell lines.
(5) I'm here to defend her 'til the end even if they put me in jail."
(6) PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody.
(7) TIL grown in the presence of IL-4 significantly reduced the level of non-specific, non-major histocompatibility complex-restricted antitumor activity (P < 0.01 for allogeneic renal, nonrenal, and NK-sensitive K562 cells), while exhibiting no effect on the level of autologous killing.
(8) In contrast, immune T cells (including some TIL) are MHC-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (TNF beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell DNA fragmentation.
(9) Much has been learned about TIL biology and their functional characteristics recently, but only few clinical trials have been completed to date.
(10) Tumor-infiltrating lymphocytes (TIL) from human pulmonary tumors have been studied as a model for local depression of cell-mediated immunity at the tumor site.
(11) Phenotypic analysis of expanded TIL and two clones further analyzed in more detail showed CD3+, CD4+, CD8-, and 2H4+ (CD45R+) expression.
(12) The studies demonstrate the feasibility of TILs as suitable cellular vehicles for the introduction of therapeutic genes into patients receiving autologous TILs.
(13) High levels of activity were exhibited by TIL against both P815, which is resistant to natural killer (NK) cells, and to NK-sensitive YAC-1 cells.
(14) To improve the potency of TILs, new cytokines with T-cell stimulatory effects used alone or in combination with interleukin-2 (IL-2) are currently being investigated.
(15) On the other hand, TIL derived from the 2 patients whose melanoma cell lines had lost expression of HLA-A2 had a predominant CD4 phenotype and virtually no cytotoxic activity.
(16) These observations may imply the possibility of adoptive immunotherapy using TIL against human primary liver tumors.
(17) Titration of K562 targets in a 51Cr release assay revealed that untreated TIL have low cytotoxicity (4.32%) compared to untreated PBL (34.3%, P = less than 0.001).
(18) Dominant rearrangements of T-cell receptor (TCR) beta-chain genes are reported among tumor-infiltrating lymphocytes (TIL).
(19) This augmentation of TIL-mediated antitumor activity was dependent on the dose of radiation used.
(20) Those TIL expressing activation antigens were CD2+, SIg-.
Tilt
Definition:
(n.) A covering overhead; especially, a tent.
(n.) The cloth covering of a cart or a wagon.
(n.) A cloth cover of a boat; a small canopy or awning extended over the sternsheets of a boat.
(v. t.) To cover with a tilt, or awning.
(v. t.) To incline; to tip; to raise one end of for discharging liquor; as, to tilt a barrel.
(v. t.) To point or thrust, as a lance.
(v. t.) To point or thrust a weapon at.
(v. t.) To hammer or forge with a tilt hammer; as, to tilt steel in order to render it more ductile.
(v. i.) To run or ride, and thrust with a lance; to practice the military game or exercise of thrusting with a lance, as a combatant on horseback; to joust; also, figuratively, to engage in any combat or movement resembling that of horsemen tilting with lances.
(v. i.) To lean; to fall partly over; to tip.
(n.) A thrust, as with a lance.
(n.) A military exercise on horseback, in which the combatants attacked each other with lances; a tournament.
(n.) See Tilt hammer, in the Vocabulary.
(n.) Inclination forward; as, the tilt of a cask.
Example Sentences:
(1) The tilt was reproduced with a typical spread of about 10 degrees.
(2) The compromised ice sheet tilts and he sinks into the Arctic Sea on the back of his faltering white Icelandic pony.
(3) Moreover, the majority of the 'out of phase' units showed an increased discharge during side-up animal tilt and side-down neck rotation.
(4) It appears impossible to define a "positive" tilt test that would adequately identify patients with clinically significant dehydration or blood loss; this is due to the large variance in patients' orthostatic measurements both in a healthy and in an ill state and the lack of a significant correlation of orthostatic measurements to a level of dehydration.
(5) The most frequently occurring signs were: tilting of the disc (89%), oblique direction of the vessels (89%) and myopic astigmatism (96%).
(6) Patellar subluxation may improve substantially following either lateral release or anteromedial tibial tubercle transfer, but this study suggests that correction of subluxation is less consistent than reduction of abnormal tilt with tibial tubercle transfer or lateral release alone.
(7) The calculated separation between the centers of these two pigments (using an extended version of the exciton theory) is about 10 A, the pigments' molecular planes are tilted by about 20 degrees, and their N1-N3 axes are rotated by 150 degrees relative to each other.
(8) The diagnostic criterion was a difference in talar tilt of 6 or more degrees between the injured and uninjured foot on inversion stress radiographs.
(9) Failure was more likely with a subluxated, tilted, or excessively thick patella or flexed femoral component.
(10) Past measurements have shown that the intensity range is reduced at the extremes of the F0 range, that there is a gradual upward tilt of the high- and low-intensity boundaries with increasing F0, and that a ripple exists at the boundaries.
(11) Pulmonary ventilation parameters (breathing depth, frequency and minute volume, and alveolar ventilation) of 5 healthy male test subjects who performed a 20-minute tilt test were analyzed.
(12) Nonspecific baroreflex loading maneuvers such as head-down tilt readily suppress stimulated arginine vasopressin levels in normal humans.
(13) Meanwhile, among hepatic and systemic hemodynamics, wedged hepatic venous pressure, hepatic venous pressure gradient, free hepatic venous pressure, cardiac index, systolic blood pressure, systemic vascular resistance, and stroke volume were found to have changed significantly after tilting.
(14) Among the implications of the less-than-impressive substantive results of the MWTA is the lesson that while a crisis can tilt the political balance in favor of regulatory legislation, it cannot as readily produce the consensus required to sustain that regulation at the levels promised in the legislation.
(15) Whole body tilt from supine to 45 degrees head-up was associated with increased heart rate and an insignificant rise in MABP in both groups, although a rise in plasma AVP occurred in control subjects only.
(16) During tilt, both systolic (S) blood pressure (BP) (p less than 0.01) and diastolic (D) BP (p less than 0.05) increased in HT, but not in NT.
(17) Three trials on the tilting plane significantly elevated the corticosterone concentration in saline-treated ANT rats, but produced no additional increase in drug-treated ANT rats.
(18) The transition moment either tilts further into the membrane or loses some of its axial orientation, or both.
(19) All initially positive patients were rendered tilt negative by therapy.
(20) Midodrine significantly increased the basal rate of cardiac output and attenuated the decrease in cardiac output induced by the tilt.