(1) Analysis of lymphocyte subsets by flow cytometry demonstrated Leu 4, 43.6% (T cells); Leu 10, 10.5% (B cells) and Leu 7, 13.1% (natural killer (NK) cells) in TIL.
(2) With one exception none of the purified CD4+ or CD8+ TILs expressed any significant levels of CD56, while the unseparated TILs contained varying numbers of CD3+CD56+ and CD3-CD56+ populations.
(3) Furthermore, it was also confirmed that TIL-LAK cells could be induced in autochthonous mouse tumor systems and human gastric tumor systems.
(4) However, IL-4 did not alter the cytotoxic activity of TILs against autologous tumor cells and established tumor cell lines.
(5) I'm here to defend her 'til the end even if they put me in jail."
(6) PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody.
(7) TIL grown in the presence of IL-4 significantly reduced the level of non-specific, non-major histocompatibility complex-restricted antitumor activity (P < 0.01 for allogeneic renal, nonrenal, and NK-sensitive K562 cells), while exhibiting no effect on the level of autologous killing.
(8) In contrast, immune T cells (including some TIL) are MHC-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (TNF beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell DNA fragmentation.
(9) Much has been learned about TIL biology and their functional characteristics recently, but only few clinical trials have been completed to date.
(10) Tumor-infiltrating lymphocytes (TIL) from human pulmonary tumors have been studied as a model for local depression of cell-mediated immunity at the tumor site.
(11) Phenotypic analysis of expanded TIL and two clones further analyzed in more detail showed CD3+, CD4+, CD8-, and 2H4+ (CD45R+) expression.
(12) The studies demonstrate the feasibility of TILs as suitable cellular vehicles for the introduction of therapeutic genes into patients receiving autologous TILs.
(13) High levels of activity were exhibited by TIL against both P815, which is resistant to natural killer (NK) cells, and to NK-sensitive YAC-1 cells.
(14) To improve the potency of TILs, new cytokines with T-cell stimulatory effects used alone or in combination with interleukin-2 (IL-2) are currently being investigated.
(15) On the other hand, TIL derived from the 2 patients whose melanoma cell lines had lost expression of HLA-A2 had a predominant CD4 phenotype and virtually no cytotoxic activity.
(16) These observations may imply the possibility of adoptive immunotherapy using TIL against human primary liver tumors.
(17) Titration of K562 targets in a 51Cr release assay revealed that untreated TIL have low cytotoxicity (4.32%) compared to untreated PBL (34.3%, P = less than 0.001).
(18) Dominant rearrangements of T-cell receptor (TCR) beta-chain genes are reported among tumor-infiltrating lymphocytes (TIL).
(19) This augmentation of TIL-mediated antitumor activity was dependent on the dose of radiation used.
(20) Those TIL expressing activation antigens were CD2+, SIg-.
Tip
Definition:
(n.) The point or extremity of anything; a pointed or somewhat sharply rounded end; the end; as, the tip of the finger; the tip of a spear.
(n.) An end piece or part; a piece, as a cap, nozzle, ferrule, or point, applied to the extreme end of anything; as, a tip for an umbrella, a shoe, a gas burner, etc.
(n.) A piece of stiffened lining pasted on the inside of a hat crown.
(n.) A thin, boarded brush made of camel's hair, used by gilders in lifting gold leaf.
(n.) Rubbish thrown from a quarry.
(v. t.) To form a point upon; to cover the tip, top, or end of; as, to tip anything with gold or silver.
(v. t.) To strike slightly; to tap.
(v. t.) To bestow a gift, or douceur, upon; to give a present to; as, to tip a servant.
(v. t.) To lower one end of, or to throw upon the end; to tilt; as, to tip a cask; to tip a cart.
(v. i.) To fall on, or incline to, one side.
(n.) A light touch or blow; a tap.
(n.) A gift; a douceur; a fee.
(n.) A hint, or secret intimation, as to the chances in a horse race, or the like.
Example Sentences:
(1) This study examined both the effect of variations in optical fiber tip and in light wavelength on laser-induced hyperthermia in rat brain.
(2) Sickle and normal discocytes both showed membrane elasticity with reversion to original cell shape following release of the cell from its aspirated position at the pipette tip.
(3) The complication might have been prevented by measurements of U and I, reflecting changes in impedance or by measurements of catheter tip temperature (T).
(4) But what about phenomena such as table tipping and Ouija boards?
(5) The relationship between technique of obtaining Papanicolaou smears, presence of endocervical cells, and rate of cervical neoplasia was studied by comparing an endocervical and ectocervical nylon brush (Bayne brush), Ayre spatula plus endocervical brush, and spatula plus cotton-tipped swab in a randomized, prospective trial involving 11,061 patients.
(6) Eight electrodes of different size and tip characteristics were evaluated at different temperatures and time settings, both in vitro and in vivo.
(7) Neither was the intra-VMH infusion of MA effective if: (i) the rats were not primed with estrogen; (ii) the tips of the cannulae were outside the VMH; or (iii) it was preceded by an intra-VMH infusion of the alpha 1b-antagonist, chloroethylclonidine (CEC).
(8) "We know that a country has tipped when local-to-local connections outnumber local to foreign," he added.
(9) An inner cannula containing PGE2 or PGF2alpha at its tip was inserted into the previously implanted outer cannula.
(10) The linear flow accelerator failed to prevent, but did delay, catheter tip recoil in proportion to the prolongation of contrast medium injection time.
(11) The inter-connecting linkage system develops postnatally, and the 'tip-linkages' are already found in one-week-old mice, suggesting that the critical organization of the micromechanics of the stereocilia matures rapidly during the postnatal period.
(12) A new simplified technique for evaluating the internal pudendal artery and the penile vessels is described using a new catheter configuration with a very short 90 degrees-angled tip.
(13) Tipping petrol on a fire isn’t going to get the heat out of it,” he told ABC radio.
(14) When used in snail neurones such electrodes gave very similar pHi values to those recorded simultaneously by recessed-tip glass micro-electrodes.
(15) This study demonstrates the limitations of the Q-Tip test and reconfirms the need for more sensitive and specific urodynamic investigations of the incontinent woman.
(16) Following orthodontic treatment the canine's incisal edge occlusion demonstrates the tip and torque present in the appliance that was used.
(17) After 4 weeks of in vivo growth, extensive growth of arborizing ducts was apparent in recombinants composed of urogenital sinus mesenchyme and a single adult prostatic ductal tip.
(18) Conversely, serum starvation decreased TIP levels within 1 hr.
(19) He unleashes a scorching drive from about 18 yards, which Joe Hart tips wide via his right post.
(20) One patient harbored a basilar trunk aneurysm, 1 an aneurysm of the proximal posterior cerebral artery, 3 an aneurysm of the superior cerebellar artery, and 10 an aneurysm at the basilar tip.