(1) Analysis of lymphocyte subsets by flow cytometry demonstrated Leu 4, 43.6% (T cells); Leu 10, 10.5% (B cells) and Leu 7, 13.1% (natural killer (NK) cells) in TIL.
(2) With one exception none of the purified CD4+ or CD8+ TILs expressed any significant levels of CD56, while the unseparated TILs contained varying numbers of CD3+CD56+ and CD3-CD56+ populations.
(3) Furthermore, it was also confirmed that TIL-LAK cells could be induced in autochthonous mouse tumor systems and human gastric tumor systems.
(4) However, IL-4 did not alter the cytotoxic activity of TILs against autologous tumor cells and established tumor cell lines.
(5) I'm here to defend her 'til the end even if they put me in jail."
(6) PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody.
(7) TIL grown in the presence of IL-4 significantly reduced the level of non-specific, non-major histocompatibility complex-restricted antitumor activity (P < 0.01 for allogeneic renal, nonrenal, and NK-sensitive K562 cells), while exhibiting no effect on the level of autologous killing.
(8) In contrast, immune T cells (including some TIL) are MHC-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (TNF beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell DNA fragmentation.
(9) Much has been learned about TIL biology and their functional characteristics recently, but only few clinical trials have been completed to date.
(10) Tumor-infiltrating lymphocytes (TIL) from human pulmonary tumors have been studied as a model for local depression of cell-mediated immunity at the tumor site.
(11) Phenotypic analysis of expanded TIL and two clones further analyzed in more detail showed CD3+, CD4+, CD8-, and 2H4+ (CD45R+) expression.
(12) The studies demonstrate the feasibility of TILs as suitable cellular vehicles for the introduction of therapeutic genes into patients receiving autologous TILs.
(13) High levels of activity were exhibited by TIL against both P815, which is resistant to natural killer (NK) cells, and to NK-sensitive YAC-1 cells.
(14) To improve the potency of TILs, new cytokines with T-cell stimulatory effects used alone or in combination with interleukin-2 (IL-2) are currently being investigated.
(15) On the other hand, TIL derived from the 2 patients whose melanoma cell lines had lost expression of HLA-A2 had a predominant CD4 phenotype and virtually no cytotoxic activity.
(16) These observations may imply the possibility of adoptive immunotherapy using TIL against human primary liver tumors.
(17) Titration of K562 targets in a 51Cr release assay revealed that untreated TIL have low cytotoxicity (4.32%) compared to untreated PBL (34.3%, P = less than 0.001).
(18) Dominant rearrangements of T-cell receptor (TCR) beta-chain genes are reported among tumor-infiltrating lymphocytes (TIL).
(19) This augmentation of TIL-mediated antitumor activity was dependent on the dose of radiation used.
(20) Those TIL expressing activation antigens were CD2+, SIg-.
Toil
Definition:
(n.) A net or snare; any thread, web, or string spread for taking prey; -- usually in the plural.
(v. i.) To exert strength with pain and fatigue of body or mind, especially of the body, with efforts of some continuance or duration; to labor; to work.
(v. t.) To weary; to overlabor.
(v. t.) To labor; to work; -- often with out.
(v.) Labor with pain and fatigue; labor that oppresses the body or mind, esp. the body.
Example Sentences:
(1) Estonia had been reduced to 10 men early in the second half yet Hodgson’s men had to toil away for another 25 minutes before the goal, direct from Wayne Rooney’s free-kick, that soothed their mood and maintained their immaculate start to this qualifying programme.
(2) It would also throw a light on the appalling conditions in which cheap migrant labour is employed to toil Europe's agriculturally rich southern land.
(3) We're all in this together, says George Osborne, and with workers' wages lagging inflation, it is only fair that those who don't have to toil for a living should share in the squeeze.
(4) Kelly and KR continued to toil in the Wembley heat to no avail and after the forward Brad Singleton charged over for Leeds’ next, their race was well and truly run.
(5) Northampton toiled manfully to seek a way back into the tie with Holmes, two-goal hero from the first match, making a number of threatening runs.
(6) But though he’s helped liberate thousands of kids from servitude (and into education), 13 million children still toil in India’s supply chain alone.
(7) Around the world, young workers expected to toil for months at a time for little or no pay are battling to be rewarded fairly.
(8) The striker toiled alone for much of the match and even though Mauricio Pochettino insisted afterwards that there is no reason for Kane to be unable to continue carrying such a burden for the entire season, it is easy to see why Spurs are interested in signing another striker, notably West Bromwich Albion’s Saido Berahino.
(9) We drive to the seafront, where two fishermen are toiling to the rear of the beach, turning cogs that wind a rope attached to their boat to tug it in from the sea over wooden planks.
(10) Six years after Rover's collapse, there is certainly plenty of open space at the centre of this formerly thriving town: hundreds of acres of flattened muddy fields where 6,000 skilled workers once toiled.
(11) A place in the top four, now just a point away, is there for the taking given Chelsea’s toils across town and there is enough quality and momentum behind this team to take advantage.
(12) After 90 minutes of unremitting toil, perspiration and scant regard for loftier reputations, blame was starting to be apportioned.
(13) Take simple ingredients: an economy enduring bad times, a coalition in the toils, a world full of problems.
(14) We see Schenck, after toiling heroically in the underground field hospital, looking shocked at the antics of Hitler's entourage.
(15) Roy Hodgson claimed he always believed England would recover from their toils at the World Cup to progress unbeaten to next summer’s European Championship as his side completed a perfect qualifying record on a night marred by crowd trouble in Lithuania.
(16) He toiled away at drafting bills for Labour’s first 100 days in power – ready in time for tomorrow’s Queen’s speech.
(17) Paulinho’s toils have been the subject of tremendous scrutiny, after a season in which he did not influence games at Tottenham Hotspur as impressively as he did for Brazil at the Confederations Cup.
(18) What today’s landmark employment tribunal has done is challenge the business logic that suggests Uber drivers are not toiling for the firm but entrepreneurs working for themselves.
(19) But the second is his belief that some people are "somebodys" who are born to own, control and enjoy while others are "nobodys" whose lot is to serve, toil and endure – a mindset shared by most Nigerians, at every stratum of our society.
(20) 3) In case of "lacking genius" the individual toils in vain with science.