What's the difference between tolerance and variation?

Tolerance


Definition:

  • (n.) The power or capacity of enduring; the act of enduring; endurance.
  • (n.) The endurance of the presence or actions of objectionable persons, or of the expression of offensive opinions; toleration.
  • (n.) The power possessed or acquired by some persons of bearing doses of medicine which in ordinary cases would prove injurious or fatal.

Example Sentences:

  • (1) within 12 h of birth followed by similar injections every day for 10 consecutive days and then every second day for a further 8 weeks, with mycoplasma broth medium (tolerogen), to induce immune tolerance.
  • (2) No differences between the two substances were observed with respect to side effects and general tolerability.
  • (3) This treatment is usually well tolerated but not devoid of systemic effects.
  • (4) Well tolerated from the clinical and laboratory points of view, it proved remarkably effective.
  • (5) To estimate the age of onset of these differences, and to assess their relationship to abdominal and gluteal adipocyte size, we measured adiposity, adipocyte size, and glucose and insulin concentrations during a glucose tolerance test in lean (less than 20% body fat), prepubertal children from each race.
  • (6) Although temazepam was effective for maintaining sleep with short-term use, there was rapid development of tolerance for this effect with intermediate-term use.
  • (7) testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain.
  • (8) There were no biochemical or haematological abnormalities caused by prazosin but on continued therapy 16 patients developed tolerance to its effect.
  • (9) Characerization of further parameters such as relative susceptibility to tolerance induction and relative degree of specificity was not possible with the use of KLH as the antigen.
  • (10) Because of these different direct and indirect actions, a sudden cessation of sinus node activity or sudden AV block may result in the diseased heart in a prolonged and even fatal cardiac standstill, especially if the tolerance to ischemia of other organs (notably the brain) is decreased.
  • (11) Efficacy and tolerability of perorally administered desmopressin were evaluated in 12 adult patients suffering from central diabetes insipidus.
  • (12) This suggests that both blood transfusion and allograft are required for IL2 suppression and that this suppression may be related to the heart tolerance.
  • (13) At present, ACE inhibitors are preferred because they are usually better tolerated than conventional vasodilators and are clinically more effective.
  • (14) Changes in pain tolerance after administration of differently labelled placebos were studied by measuring the reaction time after a cold stimulus.
  • (15) TK1 showed the most restricted substrate specificity but tolerated 3'-modifications of the sugar ring and some 5-substitutions of the pyrimidine ring.
  • (16) Provided that adequate reflection is given and the appropriate moment chosen, it is well tolerated and provides all the necessary information.
  • (17) After large bowel removal, there was impaired glucose tolerance and attenuated plasma insulin secretion.
  • (18) Cardiac pump function is not affected, even in patients with ventricular dysfunction or heart failure, in whom chronic oral administration of the drug is well tolerated.
  • (19) These agents have been well-tolerated and generally produce a high incidence of sustained improvements in neutrophil counts and marrow morphology, although hemoglobin and platelet counts have generally not been altered.
  • (20) The above treatment is tolerated well and no serious side effects have been observed.

Variation


Definition:

  • (n.) The act of varying; a partial change in the form, position, state, or qualities of a thing; modification; alternation; mutation; diversity; deviation; as, a variation of color in different lights; a variation in size; variation of language.
  • (n.) Extent to which a thing varies; amount of departure from a position or state; amount or rate of change.
  • (n.) Change of termination of words, as in declension, conjugation, derivation, etc.
  • (n.) Repetition of a theme or melody with fanciful embellishments or modifications, in time, tune, or harmony, or sometimes change of key; the presentation of a musical thought in new and varied aspects, yet so that the essential features of the original shall still preserve their identity.
  • (n.) One of the different arrangements which can be made of any number of quantities taking a certain number of them together.

Example Sentences:

  • (1) The variation in thickness of the LLFL may modulate the species causing damage to the cells below it.
  • (2) There was appreciable variation in toothbrush wear among subjects, some reducing their brush to a poor state in 2 weeks whereas with others the brush was rated as "good" after 10 weeks.
  • (3) Correction for within-person variation in urinary excretion increased this partial correlation coefficient between intake and excretion to 0.59 (95% CI = 0.03 to 0.87).
  • (4) The coefficient of variation in the integrated area of a single peak is 16%.
  • (5) Sequence variation in the gp116 component of cytomegalovirus envelope glycoprotein B was examined in 11 clinical strains and compared with variation in gp55.
  • (6) Effects of habitual variations in napping on psychomotor performance, short-term memory and subjective states were investigated.
  • (7) A small variation in T1 was found between older (greater than 40 years) and younger (less than 40 years) subjects, but no such effect was observed in the case of T2.
  • (8) The variation of the activity of the peptidase with pH in the presence of various inhibitors was investigated in both control and insulted muscle fibres.
  • (9) This study examined both the effect of variations in optical fiber tip and in light wavelength on laser-induced hyperthermia in rat brain.
  • (10) = 19) with a very low, but statistically significant, correlation with the AUC, r = 0.35 (p less than 0.05), thus demonstrating a very great individual variation in sensitivity to cimetidine.
  • (11) Once the normal variations are mastered, appreciation of retinal, choroidal, optic nerve, and vitreal abnormalities is possible.
  • (12) Regression analysis on the 21 clinical or laboratory parameters studied showed that the only variable independently associated with CSF-FN was the total protein concentration in the CSF; this, however, explained only 14% of the observed variation in the CSF-FN concentration and did not show any correlation with CNS involvement.
  • (13) Pharmacokinetic parameters, such as these clearances, had large intersubject variations.
  • (14) Variability (CV = 0.7%) in body volume of a 45-year-old reference man measured by SH method was very similar to variation (CV = 0.6%) in mass volume of the 60-1 prototype.
  • (15) Further analysis of the role of sex steroid hormones is required in view of the sex variations reported.
  • (16) The overall result of this system has been to decrease the coefficients of variation to below 5% for all the milk and serum proteins tested.
  • (17) The variation in age-specific rates with age was similar for all cancers, as demonstrated by large positive correlation coefficients between age-incidence patterns averaged over all populations.
  • (18) Even though there are variations among equipment bearing the same model number it was considered worthwhile to make available relative cavitational and temperature data.
  • (19) Accordingly, LPA proved an extremely stable characteristic which did not show any substantial variations in the course of five years.
  • (20) Variation in patient mix was a major determinant of the large variations in resource use.