What's the difference between tolerance and weakness?

Tolerance


Definition:

  • (n.) The power or capacity of enduring; the act of enduring; endurance.
  • (n.) The endurance of the presence or actions of objectionable persons, or of the expression of offensive opinions; toleration.
  • (n.) The power possessed or acquired by some persons of bearing doses of medicine which in ordinary cases would prove injurious or fatal.

Example Sentences:

  • (1) within 12 h of birth followed by similar injections every day for 10 consecutive days and then every second day for a further 8 weeks, with mycoplasma broth medium (tolerogen), to induce immune tolerance.
  • (2) No differences between the two substances were observed with respect to side effects and general tolerability.
  • (3) This treatment is usually well tolerated but not devoid of systemic effects.
  • (4) Well tolerated from the clinical and laboratory points of view, it proved remarkably effective.
  • (5) To estimate the age of onset of these differences, and to assess their relationship to abdominal and gluteal adipocyte size, we measured adiposity, adipocyte size, and glucose and insulin concentrations during a glucose tolerance test in lean (less than 20% body fat), prepubertal children from each race.
  • (6) Although temazepam was effective for maintaining sleep with short-term use, there was rapid development of tolerance for this effect with intermediate-term use.
  • (7) testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain.
  • (8) There were no biochemical or haematological abnormalities caused by prazosin but on continued therapy 16 patients developed tolerance to its effect.
  • (9) Characerization of further parameters such as relative susceptibility to tolerance induction and relative degree of specificity was not possible with the use of KLH as the antigen.
  • (10) Because of these different direct and indirect actions, a sudden cessation of sinus node activity or sudden AV block may result in the diseased heart in a prolonged and even fatal cardiac standstill, especially if the tolerance to ischemia of other organs (notably the brain) is decreased.
  • (11) Efficacy and tolerability of perorally administered desmopressin were evaluated in 12 adult patients suffering from central diabetes insipidus.
  • (12) This suggests that both blood transfusion and allograft are required for IL2 suppression and that this suppression may be related to the heart tolerance.
  • (13) At present, ACE inhibitors are preferred because they are usually better tolerated than conventional vasodilators and are clinically more effective.
  • (14) Changes in pain tolerance after administration of differently labelled placebos were studied by measuring the reaction time after a cold stimulus.
  • (15) TK1 showed the most restricted substrate specificity but tolerated 3'-modifications of the sugar ring and some 5-substitutions of the pyrimidine ring.
  • (16) Provided that adequate reflection is given and the appropriate moment chosen, it is well tolerated and provides all the necessary information.
  • (17) After large bowel removal, there was impaired glucose tolerance and attenuated plasma insulin secretion.
  • (18) Cardiac pump function is not affected, even in patients with ventricular dysfunction or heart failure, in whom chronic oral administration of the drug is well tolerated.
  • (19) These agents have been well-tolerated and generally produce a high incidence of sustained improvements in neutrophil counts and marrow morphology, although hemoglobin and platelet counts have generally not been altered.
  • (20) The above treatment is tolerated well and no serious side effects have been observed.

Weakness


Definition:

  • (n.) The quality or state of being weak; want of strength or firmness; lack of vigor; want of resolution or of moral strength; feebleness.
  • (n.) That which is a mark of lack of strength or resolution; a fault; a defect.

Example Sentences:

  • (1) There was a weak relation between AER and both systolic and diastolic blood pressures.
  • (2) Muscle weakness and atrophy were most marked in the distal parts of the legs, especially in the gastrocnemius and soleus muscles, and then spread to the thighs and gluteal muscles.
  • (3) Consensual but rationally weak criteria devised to extract inferences of causality from such results confirm the generic inadequacy of epidemiology in this area, and are unable to provide definitive scientific support to the perceived mandate for public health action.
  • (4) The strengths and weaknesses of each technique are described in this article.
  • (5) In group V, five cases of Taenia saginata parasitosis were studied showing a weak positive reading.
  • (6) Although the longest period required for resolving weakness was three days, the MRI, the CT and the electroencephalogram revealed no significant abnormality.
  • (7) Her muscle weakness and hyperCKemia markedly improved by corticosteroid therapy, suggesting that the diagnosis was compatible with polymyositis (PM).
  • (8) It was concluded that Ta acts as a weak zeitgeber in laboratory rats and has greater effects on males compared to females.
  • (9) And adding to this toxic mix, was the fear that the hung parliament would lead to a weak government.
  • (10) Sensory loss, motor weakness, paraesthesia and a new pain were found as complications in 12, 7, 4 and 6 patients, respectively.
  • (11) Here's Dominic's full story: US unemployment rate drops to lowest level in six years as 288,000 jobs added Michael McKee (@mckonomy) BNP economists say jobless rate would have been 6.8% if not for drop in participation rate May 2, 2014 2.20pm BST ING's Rob Carnell is also struck by the "extraordinary weakness" of US wage growth .
  • (12) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
  • (13) The weakness was treated by intensive physical rehabilitation with complete and sustained recovery in all cases.
  • (14) It also showed weak inhibition of the solid type of Ehrlich carcinoma and prolonged the survival period of mice inoculated with L-1210 cells.
  • (15) Exposure to whole cigarette smoke from reference cigarettes results in the prompt (peak activity is 6 hrs), but fairly weak (similar to 2 fold), induction of murine pulmonary microsomal monooxygenase activity.
  • (16) Though the concept of phase, known also as focus, is a very helpful notion, its empirical foundation is yet very weak.
  • (17) DL 071 IT, a new potent non-selective beta-adrenergic blocking drug with intrinsic sympathomimetic activity and weak membrane stabilizing activity, was evaluated alone and in comparison with oxprenolol, in six volunteers, at rest and during an exercise test.
  • (18) A variety of weak acids at and below their pK(a) are potent inhibitors of transport in Penicillium chrysogenum.
  • (19) It added that the crisis had highlighted significant weaknesses in financial regulation, with further measures needed to strengthen supervision.
  • (20) The radioprotective action in E. coli ATCC 9637 of ascorbate added to media containing the weak sensitizer, tetracycline (effect described by Pittillo and Lucas (1967)), was found to be dependent on the presence of metal catalysts of the autoxidation of ascorbate.