(n.) A hydrocarbon, C6H5.CH3, of the aromatic series, homologous with benzene, and obtained as a light mobile colorless liquid, by distilling tolu balsam, coal tar, etc.; -- called also methyl benzene, phenyl methane, etc.
Example Sentences:
(1) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.
(2) The toluene group were more approving in their attitudes towards taking other drugs.
(3) In anaerobiosis, at 25 mM sulphanilic acid, or with addition of p-toluene sulphonic acid only one regression line is obtained for the permeation in both directions.
(4) Their defect in DNA degradation was shown not only after treatment by toluene but also in crude extracts after cell disintegration by ultrasonic and in untreated starved cultures.
(5) The significance of the present findings on the mutual suppression of metabolism between benzene and toluene is discussed in relation to solvent toxicology and biological monitoring of exposure to the solvents.
(6) On the other hand, with simultaneous doses of the two substances, the blood toluene concentration was higher for the first 15-30 min than the ethanol control and the urinary excretion of hippuric acid, a main metabolite of toluene, was markedly decreased for the first 2 h. The blood ethanol in this group, on the contrary, was reduced until 1 h after administration.
(7) Toluene exposure for 4 and 12 weeks caused a significant, approximately 20%, increase in 45Ca2+ uptake into unstimulated synaptosomes.
(8) Furthermore, toluene undergoes methyl-substitution in preparations of human bone marrow incubated with S-adenosyl-L-methionine to yield o-xylene, m-xylene, and p-xylene.
(9) We have investigated the whole-body dermal penetration of styrene, xylene, toluene, perchloroethylene, benzene, halothane, hexane, and isoflurane in rats and compared the permeability constants with available human studies on vapor penetration.
(10) The metabolites were identified as a) 3-hydroxy-2,6-DAT, b) 4-hydroxy-2-acetylamino-6-aminotoluene, c) 2-acetylamino-6-aminotoluene, and d) 2,6-di(acetylamino)-toluene.
(11) Thus chronic toluene inhalation even at small concentrations changes hypothalamic reactivity in response to stress and hormonal stimuli.
(12) The coefficient to the complex action of carbon oxide and heating microclimate is equal to 2.5 and toluene++ and heating microclimate to 1.9.
(13) Expired carbon dioxide (CO2), the most sensitive index, displayed an inverted U-shaped concentration-effect curve, which increased at 100 ppm (the TLV) and decreased at 4500 ppm toluene.
(14) The paint base consisted primarily of toluene and methyl ethyl ketone.
(15) As organic solvents, 1,1,1-trichloroethane (1,1,1-TCE), trichloroethylene, tetrachloroethylene, toluene, m-xylene and trichloro-trifluoroethane (FC-113) were used in this study.
(16) There was a negative association between blood toluene and plasma levels of prolactin.
(17) Ethanol-withdrawn animals displayed an increased sensitivity to the narcotic action of toluene.
(18) One possibility is that early synaptic alterations resulting from toluene exposure may be preceded by increases in outer membrane fluidity.
(19) In experiments in vitro, neither benzene, toluene nor xylene changed the number of sister-chromatid exchanges (SCEs) or the number of chromosomal aberrations in human lymphocytes.
(20) Benzene toluene, styrene, 1,1,1-trichloroethylene, and tetrachloroethylene are taken as examples of solvents showing various toxicokinetic properties.
Tolyl
Definition:
(n.) The hydrocarbon radical, CH3.C6H4, regarded as characteristic of certain compounds of the aromatic series related to toluene; as, tolyl carbinol.
Example Sentences:
(1) Recently, we reported the characterization of a selective sigma receptor ligand, 1,3-di-o-tolyl-guanidine (DTG), that shows negligible crossreactivity with phencyclidine receptors.
(2) The inhibition of 1,3-[3H]di(2-tolyl)guanidine binding to the sigma 2 receptor by these cations differed qualitatively and quantitatively from their effects on (+)-[3H]pentazocine binding.
(3) Compounds (+)-1, (-)-1, (-)-2, and (+)-2 were compared for their binding affinities at kappa opioid, sigma, D2-dopamine, and phencyclidine (PCP) receptors in competitive binding assays using [3H]bremazocine ([3H]BREM) or [3H]U69,593, [3H]-(+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine [[3H]-(+)-3-PPP], or [3H]-1,3-di(o-tolyl)guanidine ([3H]DTG), [3H]-(-)-sulpiride [[3H]-(-)SULP], and [3H]-1- [1-(2-thienyl)cyclohexyl]piperidine ([3H]TCP), respectively.
(4) Five of these workers were clinically hypersensitive to TDI and displayed significant titers of tolyl-specific IgE antibodies in their sera.
(5) Independent immunoenzymatic and radioimmunoassay techniques indicated the absence of tolyl-specific IgG antibodies in sera from 25 workers with long-term exposure to toluene diisocyanate (TDI).
(6) To compare the actions of prototypic drugs which are selective for phencyclidine and sigma receptors, the electrophysiological effects of phencyclidine (PCP),3-[3-hydroxyphenyl]-N-(1-propyl)piperidine [+)3-PPP), and 1,3-di(2-tolyl)guanidine (DTG) on CA1 hippocampal pyramidal neurons were examined.
(7) The prostaglandin-blocking activity of meclofenamic acid, N-(2,6-dichloro-m-tolyl)anthranilic acid (CI-583), was analysed in the anaesthetized rabbit.
(8) In the present investigation, the effects of sigma ligands [WY-47384 [8-fluoro-2,3,4,5-tetrahydro-2[3-(3-pyridinyl)propyl)1H- pyrido(4,3b)indole], (+)-pentazocine, (+)-SFK 10,047 (N-allylnormetazocine), mafoprazine, opipramol, dextromethorphan, dextrorphan, (+)-3-PPP [3-(3-hydroxyphenyl)-N-propylpiperidine], (-)-butaclamol, DTG [1,3-di(2-tolyl)guanidine], rimcazole, ifenprodil and BMY-14802 [alpha-(fluorophenyl)-4-(5-fluoropyrimidinyl)-1-piperazine butanol]] on harmaline-, pentylenetetrazol (PTZ)-, methamphetamine (MA)- and D-serine-induced increases in mouse cerebellar levels of cGMP were determined.
(9) We report here the synthesis and characterization of a tritiated, symmetrically substituted guanidine derivative, 1,3-di(2-[5-3H]tolyl)guanidine ([3H]Tol2Gdn), that binds with high affinity to a single population of binding sites in guinea pig brain membrane preparations.
(10) N-[alpha-phenyl-beta-(p-tolyl)ethyl]glutaric acid monoamide were detected in the urine of rats dosed orally with 14C-PTLA.
(11) Recent studies have provided evidence that formamidine pesticides, such as chlordimeform (CDM; N'-4-chloro-o-tolyl-N,N-dimethylformamidine) or amitraz (AMZ; N'-2-4-(dimethylphenyl)-N-[((2,4-dimethylphenyl)imino)methyl]-N- methanimidamide) exert some of their toxic effects by an interaction with alpha 2-adrenoceptors.
(12) Three minor metabolites in descending order of importance were 2-hydroxymethyl-3-o-tolyl-4(3H)-quinazolinone, 2-methyl-6-hydroxy-3-o-tolyl-4(3H)-quinazolinone and 2-methyl-8-hydroxy-3-o-tolyl-4(3H)-quinazolinone.
(13) Absorption, distribution, excretion and metabolism of (-)N-[alpha-phenyl-beta-(p-tolyl)ethyl][14C]linoleamide (14C-PTLA) were studied in rats and dogs.
(14) However, only in the NC RAST did antibodies from both patients react with p-tolyl isocyanate inhibitor.
(15) The result of laboratory experiments with fenthion, disulfoton, Kitazin P (0,0-diisopropyl S-benzyl phosphorothiolate), edifenphos (0-ethyl S,S-diphenyl phosphorodithiolate) and amiprophos (0-ethyl 0-(2-nitro-p-tolyl) N-isopropyl phosphoramidothionate) suggested the participation of several factors mentioned above in the degradation of organophosphorus pesticides.
(16) The solubility and dissolution rate of five different solid forms of 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-o-tolyl-6-quinazoline-sulfonamide (metolazone) in n-butanol, water and 0.01 n HCl are investigated and thermodynamic values have been computed.
(17) Prior inhibition of APAP deacetylation by the carboxylesterase inhibitors bis(p-nitrophenyl) phosphate or tri-o-tolyl-phosphate did not alter APAP hepatotoxicity or nephrotoxicity.
(18) The major metabolite in mice, rats, guinea-pigs and rabbits was the product of hydroxylation of the tolyl ring, which was excreted as such as the glucuronide and sulphate conjugates.
(19) We tested the effects of the liver microsomal monooxygenase inhibitor SKF 525-A (Proadifen), and other P-450 substrates on the binding of [3H]dextromethorphan, [3H]3-(-3-Hydroxyphenyl)-N-(1-propyl)piperidine and (+)-[3H]1,3-Di-o-tolyl-guanidine ([3H]DTG) to the guinea pig brain.
(20) Among the tested new antihistaminic drugs (quinuclidine derivatives) quinuclidyl-3-(O-tolyl) carbinol possessed histamine releasing action (HRA) on the isolated rat mast cells.