(n.) That which has been transcribed; a writing or composition consisting of the same words as the original; a written copy.
(n.) A copy of any kind; an imitation.
(n.) A written version of what was said orally; as, a transcript of a trial.
Example Sentences:
(1) These lysates are comparable to those of Escherichia coli in transcriptional and translational fidelity and efficiency in response to a given template DNA.
(2) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(3) The promoters of the adenovirus 2 major late gene, the mouse beta-globin gene, the mouse immunoglobulin VH gene and the LTR of the human T-lymphotropic retrovirus type I were tested for their transcription activities in cell-free extracts of four cell lines; HeLa, CESS (Epstein-Barr virus-transformed human B cell line), MT-1 (HTLV-I-infected human T cell line without viral protein synthesis), and MT-2 (HTLV-I-infected human T cell line producing viral proteins).
(4) Quantitative determinations indicate that the amount of PBG-D mRNA is modulated both by the erythroid nature of the tissue and by cell proliferation, probably at the transcriptional level.
(5) Here we show that this induction of AP-2 mRNA is at the level of transcription and is transient, reaching a peak 48-72 hr after the addition of RA and declining thereafter, even in the continuous presence of RA.
(6) At the fepB operator, a 31 base-pair Fur-protected region was identified, corresponding to positions -19 to +12 with respect to the transcriptional start site.
(7) A strong block to the elongation of nascent RNA transcripts by RNA polymerase II occurs in the 5' part of the mammalian c-fos proto-oncogene.
(8) In the absence of an authentic target for the MASH proteins, we examined their DNA binding and transcriptional regulatory activity by using a binding site (the E box) from the muscle creatine kinase (MCK) gene, a target of MyoD.
(9) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(10) Nevertheless, this LTR does not govern efficient transcription of adjacent genes in a transient expression assay.
(11) Other DNase I hypersensitive sites located adjacent to the S14 cap site at -65 to -265 base pairs (Hss-1) or upstream at -1.3 kb (Hss-2), -2.1 kb (Hss-3'), -5.3 kb (Hss-4), and -6.2 kb (Hss-5) remained unaffected by changes in S14 gene transcription.
(12) In vitro transcription products were analyzed for their 5' end sequences and their oligonucleotide compositions.
(13) We have investigated interactions between the erythroid transcription factor GATA-1 and factors binding two cis-acting elements commonly linked to GATA sites in erythroid control elements.
(14) Thyroid hormones suppress transcription of the gene for the beta-subunit of thyrotropin (TSH beta).
(15) An sdh-specific transcript of about 3,450 nucleotides was detected in vegetative bacteria.
(16) An attempt was made to elucidate possible participation of low molecular weight nuclear RNA's (LMWN RNA's) in the transcription process.
(17) The relative contributions of transcriptional and posttranscriptional regulation of gene expression to the increase in constitutively expressed cellular proteins were examined in mouse kidneys undergoing compensatory growth following unilateral nephrectomy (UNI-NX).
(18) Reverse transcription of retina mRNA followed by DNA amplification using D4-specific nucleotides demonstrates the presence of D4 mRNA in retina.
(19) These levels are sufficient to maintain normal in vivo rates of mRNA and rRNA synthesis, but the average density of packing of polymerases on DNA is considerably less than the maximum density predicted by Miller and Bakken (1972), suggesting that initiation of polymerases of DNA is a limiting factor in the control of transcription.
(20) In addition, a 2.6-kilobase WHV RNA transcript was found in the majority of the NL tissues.
Trial
Definition:
(n.) The act of trying or testing in any manner.
(n.) Any effort or exertion of strength for the purpose of ascertaining what can be done or effected.
(n.) The act of testing by experience; proof; test.
(n.) Examination by a test; experiment, as in chemistry, metallurgy, etc.
(n.) The state of being tried or tempted; exposure to suffering that tests strength, patience, faith, or the like; affliction or temptation that exercises and proves the graces or virtues of men.
(n.) That which tries or afflicts; that which harasses; that which tries the character or principles; that which tempts to evil; as, his child's conduct was a sore trial.
(n.) The formal examination of the matter in issue in a cause before a competent tribunal; the mode of determining a question of fact in a court of law; the examination, in legal form, of the facts in issue in a cause pending before a competent tribunal, for the purpose of determining such issue.
Example Sentences:
(1) A former Berlusconi aide, Valter Lavitola, is also on trial for being the alleged intermediary in the bribe.
(2) We have addressed the effect of late intensification with autologous bone marrow transplantation on SCLC through a randomized clinical trial.
(3) Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial.
(4) Currently, photodynamic therapy is under FDA-approved clinical investigational trials in the treatment of tumors of the skin, bronchus, esophagus, bladder, head and neck, and of gynecologic and ocular tumors.
(5) In the clinical trials in which there was complete substitution of fat-modified ruminant foods for conventional ruminant products the fall in serum cholesterol was approximately 10%.
(6) We report the results of a double-blind, placebo-controlled trial of acitretin (Soriatane) in 15 patients with moderate to severe psoriasis.
(7) A 24-h test trial employing a dry target demonstrated a robust memory for the training manifested in passive avoidance behavior.
(8) Statistically significant differences were found mainly in the randomized trial, where during the first and second years, respectively, adenoidectomy subjects had 47% and 37% less time with otitis media than control subjects and 28% and 35% fewer suppurative (acute) episodes than control subjects.
(9) Twenty volunteers were used for the measurement of pedal pressures for 15 trials during three separate sessions.
(10) A previous trial into the safety and feasibility of using bone marrow stem cells to treat MS, led by Neil Scolding, a clinical neuroscientist at Bristol University, was deemed a success last year.
(11) We are currently conducting a trial to compare the ability of DHPG administered plus an anti-CMV immune globulin preparation with acyclovir to prevent posttransplant TI-CMV disease.
(12) At the trial Arena admitted involvement in criminal activity, but insisted he was innocent of the murders.
(13) Recently reported unfavorable clinical results (i.e., a high incidence of pain) have led to the discontinuation of one trial of porous polyethylene.
(14) According to the experience of clinical trials the recommended ciprofloxacin dose varies between 100 and 500 mg b.i.d.
(15) Eighty micrograms of the topically active parasympatholytic drug ipratropium were applied intranasally four times daily in 20 adults with perennial rhinitis and severe watery rhinorrhoea in a double-blind controlled cross-over trial.
(16) A bouncy function has now been incorporated into a knee of the semi-automatic knee lock design in a pilot laboratory trial involving six patients.
(17) lengths with the subjects equally divided into these four groups: distributed trials, distributed sessions; distributed trials, massed sessions; massed trials, distributed sessions; and massed trials, massed sessions.
(18) A prospective randomized trial was conducted at Srinagarind and Khon Kaen hospitals.
(19) Of these, 41 were given a trial of sulfapyridine or dapsone, and six showed a significant response.
(20) The initiation of clinical trials should be a primary goal of gene therapy research programs.