(n.) A three-wheeled velocipede. See Illust. under Velocipede. Cf. Bicycle.
Example Sentences:
(1) Accidentally discovered nearly 40 years ago as the first true antidepressants, the MAOIs soon fell into disfavor due to concerns about toxicity and seemingly lesser efficacy compared with the newer tricyclic compounds.
(2) The results prove the efficacy of the drug in all the examined patients, along with the rapidity of effects in comparison with the tricyclic antidepressants.
(3) After application of tricyclic antidepressant a larger increase in pulmonary arterial enddiastolic pressure was observed during ergometric exercise.
(4) Tricyclic antidepressants are often associated with adverse drug reactions in the elderly, so alternatives such as MAO inhibitors, alprazolam, bupropion and psychostimulants are currently being explored in this patient population.
(5) It appears that tricyclic antidepressants act in a fashion different from opiate drugs that alter the sensory discriminative component of pain.
(6) Effects of both tricyclic and non-tricyclic drugs on the extrinsic Cotton effects of dicumarol bound to human alpha 1-acid glycoprotein (AGP) have been investigated.
(7) It is concluded that the NA potentiation by tricyclic antidepressants is not the main reason for their cardiotoxic effects.
(8) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(9) Because new drugs, which are really "defibrillating" drugs, are available (bretylium tosylate, bethanidine, clofilium, tricyclic antidepressants, phenotiazine derivatives), we plan to investigate these defibrillating drugs in isolated hearts, found in suitable animals like dogs (sheep and swine are difficult to defibrillate) and in humans during routine electropharmacological studies.
(10) The MAOIs represent effective alternatives to the tricyclic antidepressants.
(11) All three antagonists are composed of a very similar tricyclic ring system linked to a 1-methyl-4-piperidylene ring.
(12) The effects of a series of tricyclic and non-tricyclic antidepressants on the transport of [3H]-serotonin into synaptosomal fractions from rat brain in vitro and in vivo are summarized.
(13) Uptake of [123I]MIBG into the heart was inhibited by the tricyclic drug, imipramine, and this agent also accelerated the rate of loss of [123I]MIBG.
(14) Awareness of these factors is necessary to insure proper therapeutic utilization of the tricyclics as well as to treat effectively their toxicity.
(15) Research on plasma levels of tricyclic antidepressants suggest new clinical strategies for adjusting dosages; neurochemical studies may provide an appropriate selection process for choosing a tricyclic antidepressant.
(16) The tricyclic psychotropic drug opipramol (Insidon) reacts in vitro with sodium nitrite in acidic solution to form products including mutagens for Salmonella typhimurium TA98 and TA100.
(17) This clinical trial of a new antidepressant, fluoxetine, shows it to be as effective as a standard tricyclic drug, imipramine.
(18) Contrary to our previous study, no significant correlation was obtained between the plasma concentrations of amitriptyline, nortriptyline or total tricyclics with Hamilton rating score at 6 weeks or percentage improvement after 6 weeks treatment.
(19) The effect of low doses of antidepressants (almost always a tricyclic) appeared to be less beneficial than either higher doses or clinical management without antidepressant drugs.
(20) The fractions containing congeners with two to four ortho chlorines and the di- and tricyclic compounds had no significant effects on tissue vitamin A contents.
Velocipede
Definition:
(n.) A light road carriage propelled by the feet of the rider. Originally it was propelled by striking the tips of the toes on the roadway, but commonly now by the action of the feet on a pedal or pedals connected with the axle of one or more of the wheels, and causing their revolution. They are made in many forms, with two, three, or four wheels. See Bicycle, and Tricycle.
Example Sentences:
(1) In 1818, Johnson patented his “Velocipede”, which the public dubbed the “hobby horse”.
(2) On 5 August 1878, the Bicycle Touring Club – one of Britain's first cycling clubs – was formed inside the pub when a Scotsman called Stanley Cotterell pedalled his penny farthing all the way from Edinburgh to meet like-minded "velocipede enthusiasts" from around the UK.
(3) ", before waffling on about the capital being "framed by shooting velocipedes."