(v. t.) To remove a band from; to set free from shackles or fastenings; to unite; to unfasten; to loose; as, unbind your fillets; to unbind a prisoner's arms; to unbind a load.
Example Sentences:
(1) Thus, although the fast sodium inactivation process is not required for tonic and use-dependent block of INa by disopyramide, it contributes to the fast phase of block development and unbinding from use-dependent block.
(2) Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated.
(3) Physical theories have been developed to describe many aspects of their conformational behaviour, such as the preferred shapes and shape transformations of closed vesicles, and the shape fluctuations, random-surface configurations, and adhesion and unbinding of interacting membranes.
(4) Assuming a reversible one-to-one binding reaction, the time course of DHO binding and unbinding was analysed under a variety of conditions.
(5) Sanguinarine may produce a K+-like effect upon the Na pump with consequent unbinding of ouabain.
(6) The rate constants for binding and unbinding of ATP were estimated from the dependence of the mean open time on [ATP] and from the Ki.
(7) The rate for unbinding during depolarization was independent of pHo.
(8) We suggest that these conformational changes arise from the unbinding to DNA of certain basic tails of histone(s), and that a competition for DNA binding locations exists upon the reassociation.
(9) These findings suggest than AN-132 has use dependent inhibitory action on the fast sodium channel by binding to the channel mainly during its activated state and that the unbinding rate of the drug during diastole is very slow.
(10) Because in most cases these fit a single exponential with a mean open duration like that of modified channels, we conclude that voltage-dependent toxin unbinding produced a mixed population of unmodified and modified openings.
(11) The extent of the contribution of the process of agonist binding and unbinding to adenylate cyclase activation has not been demonstrated or quantified.
(12) It is interesting that encainide and flecainide unbind slowly (15-20 seconds), whereas lidocaine and moricizine unbind rapidly (0.2-1.3 seconds).
(13) Therefore, sodium channel states regulate the binding and unbinding behaviour of antiarrhythmic drugs.
(14) Such [Ca2+]i-transients in muscle are actually subcellular spatio-temporal events that are determined dynamically by i) diffusional fluxes of Ca2+, ii) by the binding or unbinding of Ca2+ to ligands such as troponin c and calmodulin, and iii) by the various cellular processes, such as release of Ca2+ from sarcoplasmic reticulum, that produce fluxes of Ca2+ across the membranes bounding organelles or the cell.
(15) According to the model, RAC109-I and RAC109-II have significantly different unbinding rate constants for channels when they exist predominantly in rested, activated, or inactivated states, as well as significantly different binding rate constants when channels are activated.
(16) We conclude that binding and unbinding of one molecule of ATP determine the gating of ATP-sensitive K+ channel.
(17) The dissociation rate constant of DHO unbinding remained unchanged (approximately 0.06 s-1).
(18) Estimates of binding and unbinding rate constants for the sodium channel during the action potential plateau and after repolarization were of the same order as previous results obtained using microelectrode methods in vitro.
(19) Increasing the concentration of drug increased the rate of binding but had little or no effect on unbinding, as expected for a simple bimolecular reaction.
(20) Binding and unbinding of MK-801 seems to be possible only if the N-Me-D-Asp-operated channel is in the transmitter-activated state: MK-801 was effective only when applied simultaneously with N-Me-D-Asp, and recovery from MK-801 blockade was speeded by continuous exposure to N-Me-D-Asp [time constant (tau) approximately equal to 90 min at -70 to -80 mV].
Unkind
Definition:
(a.) Having no race or kindred; childless.
(a.) Not kind; contrary to nature, or the law of kind or kindred; unnatural.
(a.) Wanting in kindness, sympathy, benevolence, gratitude, or the like; cruel; harsh; unjust; ungrateful.
Example Sentences:
(1) Clearly, therefore, image is everything, especially in a world that can still be unkind to geeky people venturing out in public wearing their latest invention.
(2) You know, I don't mean to be unkind but I think you should put your phone down because you're just being a dick, really, just enjoy the gig because it's a better … it's a dick job, filming the show.
(3) Somehow, British zoos still enjoy a protected, deeply forgiving space, in a nation of pet lovers, for manifest unkindness towards animals.
(4) Mottling of teeth can have significant psychological impact on patients--particularly on adolescents, who may be subjected to much unkind teasing.
(5) This agenda might unkindly be described as systematic anti-liberalism with a seasoning of resentment and paranoia.
(6) The place to go in parliament for unkind evaluations of Miliband’s legacy is the Labour benches.
(7) But sometimes the revelations come fast, and when they do, they are usually particularly unkind.
(8) But clearly results have been immeasurably more crushing and unkind than I could ever have feared.
(9) I'd forgotten quite how swathey it was, rather unkindly imagining literary novelists and Big Thinkers in stripped-pine north London would be over-represented.
(10) And while Özil is allowed to have a poor game, it is hard to block out the memory of those unkind whispers on his departure from Madrid about his conditioning and stamina.
(11) Irony Steven Friedman , director of Rhodes and Johannesburg universities, said: "It has to be said that one of the great ironies of the debates about how we should receive Barack Obama is that, while a lot of South Africans are very sympathetic to him because he's the first African-American president, "I don't think that it's unkind to say that he's done absolutely nothing for this continent.
(12) I got to know him quite well after that and never once did I see him being unkind or inconsiderate to people.
(13) The academic Steve Bruce once unkindly stated: "When Ulster Protestants talk about being British, it is clear that the Britain they have in mind is no more recent than the 1950s, and often their points of reference are positively Victorian."
(14) Unkind though it is to remind him of his own cruel witticism aimed at Gordon Brown when he was at his weakest, there is now more than something of Mr Bean about Dr Cable.
(15) If modern life is unkind to our mental health, it’s no doubt in part because so many young people fear that admission of vulnerability will affect their employment, or their relationships, at a time when their futures are already far less clear than those of their parents.
(16) The results of this study lend weight to the argument that those who wish to have their facial abnormalities reduced may be accurately reporting that society is unkind to them.
(17) History tends to be unkind to those who embrace the evil practices of those they once denounced.
(18) Ruben Loftus-Cheek provided the visitors’ second, sliding a pass through the centre for Oscar to collect before McFadzean was aware of his presence, the finish crisply clipped into the far corner from an unkind angle.
(19) The crime also inspired a Bollywood film – on which MacKeown was never consulted, but later said “was not unkind” in its depiction of her daughter.
(20) On Thursday, as one SNP fundraising leaflet unkindly but accurately put it, the party has a chance to “complete the set”, making it the dominant force in all areas of Scotland’s political life.