(1) Unbound fractions was significantly correlated with serum albumin concentration (r = -0.344, p less than 0.046) and renal clearance (r = 0.394, p less than 0.021) but not with total body clearance or volume of distribution.
(2) During photoirradiation, both in vivo and in vitro, the serum polar (ZE)-bilirubin IX alpha concentration increased remarkably, but unbound-bilirubin values were not affected at all.
(3) Using sterile conditions, antibodies to G were incubated with a suspension of transformed cells at 4 degrees C, unbound antibodies were then removed, and the cells were incubated with the immunoabsorbent (3 micron magnetic beads; J. Ugelstad et al.
(4) A method is described for the accurate, rapid measurement of the unbound fractions of estradiol and of progesterone in small volumes of plasma or serum at 37 degrees C by a miniature method of steady-state gel filtration.
(5) Serum unbound bilirubin concentrations (UBC) and serum total bilirubin concentrations (TBC) were measured serially in 138 low birthweight (LBW) infants treated with phototherapy for non-hemolytic hyperbilirubinemia.
(6) Chemically modified RNA was incubated with L11 under conditions appropriate for specific binding of L11 and the resulting protein-RNA complex was separated from unbound RNA on Mg(2+)-containing polyacrylamide gels.
(7) After exposure to 400 microM aluminum lactate and removal of unbound aluminum, human cytoskeletal proteins were degraded two- to threefold more slowly by calpain.
(8) Unbound disopyramide is separated from protein-bound drug by filtration with an Amicon Centrifree filter, which removes 99.6% of protein and does not retain disopyramide.
(9) It is suggested that SHBG may act as one common denominator in the pathogenesis of postmenopausal osteoporosis and endometrial disease by regulating the levels of unbound, biologically active androgens and estrogens.
(10) Furthermore, the use of norharmane as an inhibitor of L-tryptophan binding did not reveal a simple relationship between its unbound concentration and BUI.
(11) [3H]Methyltrienolone-bound and unbound androgen receptors from mouse submandibular glands bound to DNA-cellulose to a similar extent after gel chromatography.
(12) The CLi of thiobarbital, thiopental and thioseconal was proportional to the unbound fraction in serum.
(13) The Factor XI activity of the platelet membrane-plasma Factor XI complex was inhibited by concanavalin A, whereas unbound plasma Factor XI retained activity.
(14) The finding that both the absolute levels of IGFBP-1 and the ratio to IGF-1 were low in amniotic fluid implies that there is a very high level of unbound, biologically active IGF-1 in this compartment in the first trimester.
(15) The coefficients when unstimulated saliva was compared to either total or unbound serum concentrations were 0.90 and 0.89, respectively.
(16) In one of the best of the recent ones ( Shakespeare Unbound , 2007) René Weis has a cool and illuminatingly open-minded analysis of whether the earlier sonnets (including 20) are directed at the young and glamorous Earl of Southampton, the poet’s patron and possible love object.
(17) The inclusion in the model of the rapidly turning over pool of triglyceride-rich particles, identified in the heparin-unbound fraction, suggests that values for triglyceride production in man have been underestimated.
(18) Three bilirubin binding tests (hydroxybenzene-azobenzoic acid dye binding method, the estimation of unbound bilirubin by horseradish peroxidase assay and the saturation of albumin by the salicylate saturation index) were performed on pre-exchange samples of blood and repeated 24 hours after the procedure.
(19) The unbound, or free, warfarin fraction was twice as high in the plasma samples withdrawn from patients with renal impairment than in the samples obtained from normal volunteers.
(20) The beta2-microglobulin in the cell-sap fraction was present in the unbound state.
Unsound
Definition:
(a.) Not sound; not whole; not solid; defective; infirm; diseased.
Example Sentences:
(1) One official wrote: "An article like this would be a heaven-sent opportunity to those who wish to get maximum publicity out of this incident to argue that the coroner was biased and for this reason the inquest was unsound."
(2) They compare dose estimates calculated by planning programs to actual doses measured in phantoms, so they cannot distinguish programming errors from measurement errors or physical unsoundness of the beam model.
(3) More lambs died and more lamb deaths were due to starvation in a group with unsound udders than in a sound udder group.
(4) This position depends on two crucial arguments that we believe are unsound: first, that gestures "are synchronized with linguistic units in speech" and, second, that gestures "have semantic and pragmatic functions that parallel those of speech."
(5) He favoured ambitious, but often unsound, development projects, and schemes to relocate millions of landless peasants and open up virgin forests paved the way for the country's current environmental crisis.
(6) It was made methodologically unsound by its employment for the naming of Nissl stained soma classes before the identity of individual somas with the physiological entities can be demonstrated.
(7) The front and hind feet from a total of 64 boars, 86 sows and 107 barrows were radiographed after necropsy to study the nature of inequalities in digits and their relation to nutrition and structural unsoundness in swine.
(8) Of the seven horses with category 2 lesions, four were training or racing, two were unsound, and one was still convalescing at the time of follow-up.
(9) JP Morgan has agreed to pay about $920m in penalties to US and UK regulators over the "unsafe and unsound practices" that led to its $6.2bn London Whale losses last year.
(10) Structured interviews conducted with 162 community-residing older adults assessed social control (direct attempts by other to influence participants' health practices and the existence of significant role obligations to others), health risk taking (medication misuse, alcohol consumption, cigarette smoking, and the overall level of unsound health practices), psychological functioning (depression, loneliness, and self-esteem), and interpersonal satisfaction (satisfaction with friends and family members).
(11) A total of 1,234 ewe lambs, representing nine breed groups, were first exposed to breeding at 7 mo of age and subsequently retained with no artificial culling, except for debilitating unsoundness, through 7 yr of production.
(12) Judge Roger Thomas QC described Hutton, arguably mentally unsound, as "wicked".
(13) A New Declaration of Independence were arguing that "monopoly capitalism is morally ugly as well as economically unsound," that in America "the large majority should be able – in accordance with the tenets of the 'American dream' … to count on living in an atmosphere of equality, in a world which puts relatively few barriers between man and man."
(14) This study revealed that certain (otherwise common and nutritionally unsound) food choices were not a major part of the subjects' habits, and could be given low priority in educational messages.
(15) The basic premise of the "psychological" explanation, that Elizabeth was physically capable of bearing children is unsound for a number of reasons.
(16) If we can make it environmentally friendly, if we can make it affordable and if we can make it safe, then in time your children and my grandchildren will all have the chance to go to space.” To critics who argue that firing rockets to take sightseers up into the darkness is environmentally unsound and unnecessary, Branson says that the passengers on his first space flights will account for an amount of carbon “not dissimilar to an upper-class seat flying from London to New York and back”, and that over the next few years they believe they can make the flights “as near as dammit carbon neutral”.
(17) is theoretically unsound, as the CPK appearance function may be significantly different from zero and yet CPK vs time may still be monoexponential.
(18) The conventional separation of modes of spread as haematogenous and lymphatic seems artificial and physiologically unsound, as tumour cells tend to recycle from one system to another.
(19) Although screening elderly people for thyroid disease is economically unsound, the physician should maintain a high index of suspicion of its presence.
(20) Surgical correction of the flexible acquired flatfoot has long been subject to procedures based on an unsound understanding of the true pathomechanics of the deformity.