(v. t.) To reverse, as what has been done; to annul; to bring to naught.
(v. t.) To loose; to open; to take to piece; to unfasten; to untie; hence, to unravel; to solve; as, to undo a knot; to undo a puzzling question; to undo a riddle.
(v. t.) To bring to poverty; to impoverish; to ruin, as in reputation, morals, hopes, or the like; as, many are undone by unavoidable losses, but more undo themselves by vices and dissipation, or by indolence.
Example Sentences:
(1) We cannot undo the damage it has done to our air quality,” she said.
(2) I am not a Muslim but I see that the cover has been read as yet more provocation, even an undoing of the unity of the marches in Paris and other cities.
(3) Amid public outcry over the Bettencourt case, Sarkozy is now likely to be forced into a U-turn before the next election, undoing his tax reforms.
(4) His interventions over the next week - first with the miners then with his former army colleagues as hundreds of thousands took to the streets of Belgrade - would prove his ex-master's undoing.
(5) He told the chair, Alexis Jay: “We will never be able to undo the wrongdoing to these children.
(6) But the role opened my eyes to certain aspects of online gaming, such as harassment, abuse, threats and even stalking, and in many ways, it is an unhappy experience that I wish I could undo.
(7) With three weeks left to election day, the onus is on Obama to mount a strong comeback in Tuesday's Long Island debate to undo some of the damage caused by his dismal showing in the first of the presidential debates in Denver a fortnight ago.
(8) Obama won praise from world leaders for his promises to undo George Bush's environmental record, but there is growing scepticism abroad that Democrats will be able to overcome opposition in Congress and pass legislation that would put America on a path to cutting its carbon emissions.
(9) Arab regional governments – and even Iran – have belatedly seen their own storm clouds of extremism, but there is tremendous work required to undo what has been done.
(10) All efforts to undo environmental protections put in place by Obama, he said, would face lengthy and compulsory processes of consultation and review, as well as the strongest possible legal challenges at every turn.
(11) President-elect Trump will be able to undo the programs and cast them into the dustbin of history with equal speed and ease.
(12) Against the top sides England will leak goals, and that will ultimately be our undoing.
(13) He is praised for responding to a chemical attack in Syria with airstrikes, for generally projecting strength in foreign policy, for undoing Obama-era regulations on the environment and business, for installing a conservative supreme court justice, for protecting American jobs, and for not letting people tell him what he can’t do.
(14) Now Google might be required to undo the changes – although Auke Haagsma, a lawyer advising the lobby group Icomp , which is critical of Google's policies, said that would be like trying to "unscramble the egg".
(15) The projected increase in 2016 would return poverty rates to their 2007 levels, undoing nearly a decade’s worth of gains,” the report stated.
(16) Labour cannot afford to undo the coalition's cuts in the next government and must expect to be unpopular, one of the party's most senior finance spokesmen will say on Friday.
(17) Jeremy’s main fault was his unfortunate choice of friends – notably Peter Bessell MP, who jointly and foolishly entered into the long-running payoff drama with Scott which was his undoing.
(18) It has helped cement Qatar’s international reach and legitimacy, yet ironically has now played a part in its undoing.
(19) The former Irish prime minister John Bruton says it would “undo much of the work of the peace process and create huge questions over borders and labour market access”.
(20) The author examines how these negative affects, the accompanying victim role, and oppositional defiance enable angry adolescents to defend against depression and loss, to demand nurturance from others, to protect their precarious inner autonomy, and to undo their humiliation and shame by vengeance and reversal.
Unknot
Definition:
(v. t.) To free from knots; to untie.
Example Sentences:
(1) Initially, all attempts to unknot or remove the catheter failed.
(2) "Well…" His delightful press secretary, Lena, starts giggling as her boss tries to unknot himself from this contradiction.
(3) The purpose of this study was to identify possible mechanisms of resistance present in these cells by using human mdr1 and topoisomerase II DNA probes, antibodies to these gene products, and P4 phage unknotting assay for topoisomerase II activities.
(4) The extractable topoisomerase II activity of Bloom's syndrome fibroblasts, as measured by unknotting of page P4 DNA, is much more strongly inhibited by cell growth in medium containing BrdU than is that of normal fibroblasts.
(5) In the present study, we found that nuclear extracts of these sublines (approximately 50- and approximately 140-fold resistant to VM-26) required 2 and 8 times more adenosine 5'-triphosphate (ATP), respectively, to achieve half-maximal stimulation of unknotting activity compared to extracts from the sensitive cells.
(6) In the presence of 500 microM ATP, equimolar concentrations of 2-bromo-dATP, dideoxy-ATP, 2-chloro-dATP, 2-fluoro-dATP, and dideoxy-GTP nucleotide analogues inhibited the unknotting activity of the Topo II enzyme.
(7) Sensitivity of the topo II unknotting assay to inhibition by VP-16 was the same for the parent and all resistant cell lines.
(8) The phage P4-unknotting activity of nuclear extracts decreased 2-fold when AA8 cells entered into the non-cycling state, but there was no difference in sensitivity to amsacrine between log- and plateau-phase nuclear extracts.
(9) Methods are described for accurate measurement of 10-100 ng of unknotted P4 DNA.
(10) Our preliminary results demonstrate remarkable activity of Topo II with specific conversion of knotted form P4 DNA to unknotted form in human kidney cancer cells, YCR and ACHN.
(11) The conditions for the reactions of relaxation, unknotting, decatenation, and catenation were found to be similar to those observed with enzymes from other eukaryotic cells.
(12) The ATP concentration required for equivalent activity in a DNA-unknotting assay is 2- to 8-fold higher in nuclear extracts from drug-resistant cell lines as compared with the parental line.
(13) Several quinolones and antitumor compounds were tested as inhibitors of purified calf thymus topoisomerase II in unknotting, catenation, radiolabeled DNA cleavage, and quantitative nonradiolabeled cleavage assays.
(14) This method check relative Topo II activity with its conversion of knotted form P4 phage DNA to unknotted form.
(15) Regular chromic material was stronger in unknotted tensile strength and fracture load for all gauges.
(16) P4 unknotting assays of the purified nuclear type II topoisomerase in the presence of m-AMSA and VM-26 indicated that the mitochondrial and nuclear enzymes behaved similarly, although the mitochondrial enzyme appeared to be inhibited more strongly.
(17) More than 99% of the inversion products were unknotted rings.
(18) The enzyme can catenate supercoiled DNA molecules, unknot DNA, and cleave double-stranded DNA.
(19) Topoisomerase II activity in nuclear extracts, as determined by the P4 phage DNA-unknotting assay, was more easily detected and measured at lower NaCl concentrations in NCI-H69 than in NCI-H187 cells.
(20) The level of DNA topoisomerase II protein, detected by antibody staining, decreased concomitantly with a general decrease in DNA topoisomerase II unknotting activity, while DNA topoisomerase I activity was not affected.