(v. t.) To open the folds of; to expand; to spread out; as, to unfold a tablecloth.
(v. t.) To open, as anything covered or close; to lay open to view or contemplation; to bring out in all the details, or by successive development; to display; to disclose; to reveal; to elucidate; to explain; as, to unfold one's designs; to unfold the principles of a science.
(v. t.) To release from a fold or pen; as, to unfold sheep.
(v. i.) To open; to expand; to become disclosed or developed.
Example Sentences:
(1) The estimated DNA compaction ratio (approximately 3-fold) is consistent with a significant degree of nucleosome unfolding in the hyperstimulated BR genes.
(2) This formalism allows resolution of the intrinsic protein folding-unfolding parameters (enthalpy, entropy, and heat capacity changes) as well as the ligand interaction parameters (binding stoichiometry, enthalpy, entropy, and heat capacity changes).
(3) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(4) When RNAase is partially unfolded Au(III) causes oxidation of methionines to the sulphoxide, and leads to almost complete unfolding (at molar equivalent ratios).
(5) In the context of a simplified diamond lattice model of a six-member, Greek key beta-barrel protein that is closely related in topology to plastocyanin, the nature of the folding and unfolding pathways have been investigated using dynamic Monte Carlo techniques.
(6) The efficiency of energy transfer between probes attached to residues 1 and 15 in the reduced state is higher than that found for the same pair of sites in the native state or reduced unfolded (in 6 M Gdn.HCl) state.
(7) Coombs's theory of data (1952, 1964) and his unfolding theory of preferential choice (1950, 1964) provided the conceptualization of metacognition in this psychophysical task context.
(8) Yet what has been unfolding in the past 15 months or so should make even the most ardent pro-European think about an orderly mechanism for making member states exit: the euro crisis and, less obviously, Hungary's backsliding from liberal democracy to a soft form of authoritarianism, or what an American paper recently called " Lukashenko lite ".
(9) Circular dichroism studies show that the conformation of each subunit is unusually resistant to change in 6 M guanidine HC1 at 25 degrees C. This suggests that exposure of the epitope by dissociation requires minimal or no unfolding of subunits.
(10) The data relative to the guanidine-induced unfolding show a sigmoidal increase of the distribution width, which is due to the transition of the protein structure from the native to the random-coiled state.
(11) The data suggest that the assessment of early trauma needs to employ a variety of measures, especially those which are related to the unfolding skills appropriate for the particular age group studied.
(12) In contrast to the biphasic unfolding of the wild-type nuclease, the unfolding of the mutant is represented by a single-phase reaction, indicating that the biphasic unfolding for the wild-type protein is caused by cis-trans isomerization about the prolyl peptide bond in the native state.
(13) 4) The unfolded map diagnosis with apical display obtained from long-axis tomogram was useful to diagnose left anterior descending coronary (LAD) lesion, which improve not only the sensitivity of LAD but also specificity of right coronary artery single vessel disease.
(14) The replacement of Arg171 by Tyr stabilizes the enzyme against thermal inactivation and unfolding.
(15) These findings and the dense structure of the scleral spur suggest that in monkey eyes, and at least in some human eyes, contraction of the ciliary muscle causes unfolding of the trabecular meshwork, not so much through the movement of the scleral spur as by movement of the interconnecting trabecular beams and fibers.
(16) The principal parameter under scrutiny was the denaturing or unfolding effects caused by the interaction of the protein with the adsorptive surfaces in each assay system.
(17) For here we see the depravity to which man can sink, the barbarity that unfolds when we begin to see our fellow human beings as somehow less than us, less worthy of dignity and life; we see how evil can, for a moment in time, triumph when good people do nothing."
(18) In contrast, import of the surface-bound unfolded precursor requires ATP, but no potential; it is accompanied by a refolding inside the mitochondria.
(19) These experiments show that yeast cells can activate a transcription factor that stimulates expression of a nuclear gene in response to the accumulation of unfolded proteins in another cellular compartment.
(20) In the present study, the reversibility of the unfolding-refolding process induced by guanidine hydrochloride was investigated for the intact protein and the isolated domains.
Unravel
Definition:
(v. t.) To disentangle; to disengage or separate the threads of; as, to unravel a stocking.
(v. t.) Hence, to clear from complication or difficulty; to unfold; to solve; as, to unravel a plot.
(v. t.) To separate the connected or united parts of; to throw into disorder; to confuse.
(v. i.) To become unraveled, in any sense.
Example Sentences:
(1) However, as the plan unravels, Professor Marcus's team turn on one another, with painfully (if painfully funny) results.
(2) Her black persona unravelled this week when Ruthanne and Larry Dolezal, a couple named on her Montana birth certificate as her biological parents, told Spokane’s KREM 2 News that her ancestry was German and Czech, with traces of Native American.
(3) Putting all this information together we can begin to unravel the problem of how the Listeria forms the cytoskeleton and what is the biological purpose of this tail.
(4) Thus, 14.7K appears to be a general inhibitor of TNF cytolysis, and as such should be an important tool in unraveling the mechanism of TNF cytolysis.
(5) This communication reviews the almost 40 years of studies by Jack Metcoff, MD, and coworkers to unravel the causes of fetal malnutrition and their efforts to prevent it.
(6) Because the housing crisis goes far beyond us Focus E15 mums | Jasmin Stone Read more Annette May, 68, from Lambeth Annette May has watched with mounting dismay as the community fabric of the council estate where she has lived for 44 years steadily unravels.
(7) Substantial progress has been made in unraveling the organization of the circadian system of Aplysia californica.
(8) The free ends of the microtubules appear unraveled; they are seen first as single elements, then as doublets, and finally are arranged into a cylinder.
(9) Unraveled filaments reconstituted from NF-L plus either NF-M or NF-H indicated that NF-M and NF-H are incorporated evenly into each protofibril.
(10) Athens was unravelling into chaos, unable to form a government and forced into fresh elections , plunging the markets into freefall as Europe's leaders abandoned any pretence that a Greek exit from the euro might not be imminent.
(11) The chancellor leaves the Treasury trying to hide the cost of his mistakes while his reputation for economic competence continues to unravel."
(12) With the eurozone unravelling and world markets in turmoil, threatening even the meagre recovery the UK economy had achieved since the onset of the credit crunch, he repeatedly evokes a mood of national emergency to explain why the coalition he forged with David Cameron is the right government for the times.
(13) Without a rescue, president Nicos Anastasiades said Cyprus would default and threaten to unravel investor confidence in the eurozone.
(14) This section was memorably captured by the computer and security expert Caspar Bowden , who wrote: "Interpreting that section requires the unravelling of a triple-nested inversion of meanings across six cross-referenced subsections, linked to a dozen other cross-linked definitions, which are all dependent on a highly ambiguous 'notwithstanding'."
(15) If the statistics aren't right the whole story, beautiful as it is, unravels," he said.
(16) But sometimes a smile is not enough.” As the latest proposed deal to avoid Greece’s bankruptcy threatens to unravel , a row is raging on Rhodes and several other Greek islands over fears that they are being unfairly targeted.
(17) George Osborne’s claim that the government secured a major corporation tax deal with Google appear to be unravelling after it emerged that a quarter of the £130m recovered by HM Revenue & Customs related to the US company’s share options scheme.
(18) I have lived in Greece my whole life and experienced the economic crisis as it unraveled the past years.
(19) As the field of human genetics successfully continues to unravel the secrets of an individual's genetic makeup, the social processes of stigmatization and ostracism of those with "undesirable" traits have the potential to increase.
(20) There's got to be a deal here between the taxpayer and the scheme member and that deal is going to unravel if the people in the public sector say they will not contemplate change."