(v. t.) To open the folds of; to expand; to spread out; as, to unfold a tablecloth.
(v. t.) To open, as anything covered or close; to lay open to view or contemplation; to bring out in all the details, or by successive development; to display; to disclose; to reveal; to elucidate; to explain; as, to unfold one's designs; to unfold the principles of a science.
(v. t.) To release from a fold or pen; as, to unfold sheep.
(v. i.) To open; to expand; to become disclosed or developed.
Example Sentences:
(1) The estimated DNA compaction ratio (approximately 3-fold) is consistent with a significant degree of nucleosome unfolding in the hyperstimulated BR genes.
(2) This formalism allows resolution of the intrinsic protein folding-unfolding parameters (enthalpy, entropy, and heat capacity changes) as well as the ligand interaction parameters (binding stoichiometry, enthalpy, entropy, and heat capacity changes).
(3) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(4) When RNAase is partially unfolded Au(III) causes oxidation of methionines to the sulphoxide, and leads to almost complete unfolding (at molar equivalent ratios).
(5) In the context of a simplified diamond lattice model of a six-member, Greek key beta-barrel protein that is closely related in topology to plastocyanin, the nature of the folding and unfolding pathways have been investigated using dynamic Monte Carlo techniques.
(6) The efficiency of energy transfer between probes attached to residues 1 and 15 in the reduced state is higher than that found for the same pair of sites in the native state or reduced unfolded (in 6 M Gdn.HCl) state.
(7) Coombs's theory of data (1952, 1964) and his unfolding theory of preferential choice (1950, 1964) provided the conceptualization of metacognition in this psychophysical task context.
(8) Yet what has been unfolding in the past 15 months or so should make even the most ardent pro-European think about an orderly mechanism for making member states exit: the euro crisis and, less obviously, Hungary's backsliding from liberal democracy to a soft form of authoritarianism, or what an American paper recently called " Lukashenko lite ".
(9) Circular dichroism studies show that the conformation of each subunit is unusually resistant to change in 6 M guanidine HC1 at 25 degrees C. This suggests that exposure of the epitope by dissociation requires minimal or no unfolding of subunits.
(10) The data relative to the guanidine-induced unfolding show a sigmoidal increase of the distribution width, which is due to the transition of the protein structure from the native to the random-coiled state.
(11) The data suggest that the assessment of early trauma needs to employ a variety of measures, especially those which are related to the unfolding skills appropriate for the particular age group studied.
(12) In contrast to the biphasic unfolding of the wild-type nuclease, the unfolding of the mutant is represented by a single-phase reaction, indicating that the biphasic unfolding for the wild-type protein is caused by cis-trans isomerization about the prolyl peptide bond in the native state.
(13) 4) The unfolded map diagnosis with apical display obtained from long-axis tomogram was useful to diagnose left anterior descending coronary (LAD) lesion, which improve not only the sensitivity of LAD but also specificity of right coronary artery single vessel disease.
(14) The replacement of Arg171 by Tyr stabilizes the enzyme against thermal inactivation and unfolding.
(15) These findings and the dense structure of the scleral spur suggest that in monkey eyes, and at least in some human eyes, contraction of the ciliary muscle causes unfolding of the trabecular meshwork, not so much through the movement of the scleral spur as by movement of the interconnecting trabecular beams and fibers.
(16) The principal parameter under scrutiny was the denaturing or unfolding effects caused by the interaction of the protein with the adsorptive surfaces in each assay system.
(17) For here we see the depravity to which man can sink, the barbarity that unfolds when we begin to see our fellow human beings as somehow less than us, less worthy of dignity and life; we see how evil can, for a moment in time, triumph when good people do nothing."
(18) In contrast, import of the surface-bound unfolded precursor requires ATP, but no potential; it is accompanied by a refolding inside the mitochondria.
(19) These experiments show that yeast cells can activate a transcription factor that stimulates expression of a nuclear gene in response to the accumulation of unfolded proteins in another cellular compartment.
(20) In the present study, the reversibility of the unfolding-refolding process induced by guanidine hydrochloride was investigated for the intact protein and the isolated domains.
Untold
Definition:
(a.) Not told; not related; not revealed; as, untold secrets.
(a.) Not numbered or counted; as, untold money.
Example Sentences:
(1) In a therapeutic tragedy perhaps even more widespread than the thalidomide disaster, untold lives were lost between 1949 and 1958 through the administration of inappropriate doses of chloramphenicol to newborn infants.
(2) In an emotional statement, the Archbishop of Canterbury, Justin Welby, said the "destructive cycle of violence has caused untold suffering".
(3) And the fact that the disclosures have led to the highest journalism rewards, have led to historic reforms in the US and around the world – all of that would be irrelevant in a prosecution under the espionage laws in the United States.” Snowden also could face an untold number of additional charges if he returned to the United States.
(4) The gratitude I feel to Velázquez for this greatest of paintings is untold; he gave me the consolation I most needed in my life.
(5) Stone's previous films include Platoon, JFK and W. The director has also made documentaries on Fidel Castro and Hugo Chavez, together with a 2012 TV series, Oliver Stone's Untold History of the United States.
(6) Maleficent, Disney's latest film out on 28 May, offers the untold back story of the villain from the 1959 animated classic Sleeping Beauty, with Jolie in the title role.
(7) Hardly any development funding for implementation has been disbursed.” 68 million children likely to die by 2030 from preventable causes, report says Read more Dr David Richmond, president of the Royal College of Obstetricians and Gynaecologists, said the series offered a “wake-up call to governments worldwide to make faster progress in reducing the number of stillbirths, which wreak untold damage on families, care givers and communities”.
(8) Miliband said: "We've got a cost of living crisis in this country and it's driving people into the arms of payday lenders and causing them untold hardship.
(9) In Africa alone, an area larger than Germany and France together has been sold for agribusiness while untold thousands of farmers have been evicted with scant compensation.
(10) Laying out a vision of continued collaboration across the Channel, the communique says: “For centuries, British scholars, scientists and artists have worked and shared ideas with their European counterparts, producing an untold number of scientific breakthroughs, academic achievements and great works of art, enriching us culturally and economically.
(11) At the moment, the NT has a record four productions running in the West End – One Man, Two Guvnors, War Horse, Untold Stories and The Curious Incident of the Dog in the Night-Time – which have created an invaluable income stream against funding cuts and the credit crunch.
(12) As a result, epileptic persons suffer untold social deprivations and discrimination in education, employment, housing, marital life, etc.
(13) A data acquisition system that automatically discards corrupted or undesirable signals would save untold hours of drudgery for researchers.
(14) Half of all species could become extinct, untold millions of people would be displaced, whole nations drowned by the sea.
(15) To deny the part your childhood advantage plays in your adult success – maybe out of ego, maybe out of embarrassment – is like Donald Trump claiming he’s a self-made billionaire while neglecting to mention he inherited untold millions from his father.
(16) It is the very foundation of our being,” says physicist and activist Vandana Shiva in the upcoming documentary SEED: The Untold Story .
(17) Very few regrets, I thought, except this one: that we had not done justice to this huge, overshadowing, overwhelming issue of how climate change will probably, within the lifetime of our children, cause untold havoc and stress to our species.
(18) Designated as Unesco World Heritage sites , both have suffered untold damage which will only be open for proper assessment when the war is over.
(19) Cooper is currently filming Dracula Untold, in the role of vampire hunter Abraham van Helsing.
(20) Their American history isn't untold, but rather a meditation on what could have – and, in their view, should – have, happened.