(n.) A small air cell, or globular space, in the interior of organic cells, either containing air, or a pellucid watery liquid, or some special chemical secretions of the cell protoplasm.
Example Sentences:
(1) Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4'-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis.
(2) Aberrant forms (elongated and twisted) in the vacuole and double virions in the plasma membrane were observed as early as 65 h after infection.
(3) Combined SEM and TEM examination of the endothelium of compressed segments revealed "craters" and "balloons", blebs and vacuoles, swollen mitochondria, dilated granular endoplasmic reticulum, and subendothelial edema.
(4) Electron microscopy revealed the presence of a hitherto unreported peculiar "pilovacuolar" inclusion in numerous mitochondria, composed of an electron dense pile or rod within a vacuole, while globular or crystalline inclusions were absent.
(5) The mode of action is as yet undetermined, but intracellular vacuoles may be the primary targets.
(6) Thin layers of carbon (20 microns) and vacuoles (30 microns) suggested a large temperature gradient along the tissue ablation front.
(7) It can be estimated that there were about 20 small vacuoles per erythrocyte.
(8) Phagosomes and dense bodies reminiscent of Russel bodies also occurred in the Mikulicz cells, in the vacuoles of which formations representing Klebsiella rhinoscleromatis were demonstrated.
(9) Thus, multiparae had very thick border zones composed predominantly of large nodules and, additionally, of vacuolated cells and fibrous tissue.
(10) Some of these vacuoles had remnants of mitochondrial cristae or were enlarged endoplasmic reticulum.
(11) Portal lipogranulomas show a distinctive morphology with fat vacuoles surrounded by macrophages.
(12) Under the electron microscope, slices appeared vacuolated near the cut surfaces, but well preserved internally (greater than 40 micron from the edge).
(13) By the time the bud was half the diameter of the mother cell, it almost always bore a vacuole.
(14) Large intracellular vacuoles, which arose from dilated cisternae of the rough-surfaced endoplasmic reticulum, were fused together, and marked swelling of the mitochondria was also noted.
(15) This exogenous protein tracer could be seen in apical vacuoles and phagosomes in the cuboidal parietal epithelium.
(16) are adherent to the cell membrane and are internalized into cytoplasmic vacuoles.
(17) This intermediate compartment contained only small amounts of cathepsin L in comparison to lysosomes and was bound by a double membrane, typical of nascent vacuoles.
(18) Large (about 2 micron in diameter), pale vacuoles, probably of extracellular character, were found mostly in the vicinity of the perivascular septum.
(19) Factors associated significantly with the degree of vacuolization were sex (females were affected more severely than males), body weight, relative liver weight, and the laboratory conducting the study.
(20) Histologic examination of one patient from each pedigree showed two characteristic findings in corneal epithelium; the previously designated "peculiar substance" in the cells, and the vacuolated homogeneous substance mostly within the cysts.
Vesicle
Definition:
(n.) A bladderlike vessel; a membranous cavity; a cyst; a cell.
(n.) A small bladderlike body in the substance of vegetable, or upon the surface of a leaf.
(n.) A small, and more or less circular, elevation of the cuticle, containing a clear watery fluid.
(n.) A cavity or sac, especially one filled with fluid; as, the umbilical vesicle.
(n.) A small convex hollow prominence on the surface of a shell or a coral.
(n.) A small cavity, nearly spherical in form, and usually of the size of a pea or smaller, such as are common in some volcanic rocks. They are produced by the liberation of watery vapor in the molten mass.
Example Sentences:
(1) 5-HT thus appears to be the preferred substrate for uptake into platelets and for movement from cytoplasm to vesicles.
(2) The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same.
(3) Reasonably good agreement is seen between theoretical apparent rate-vesicle concentration relationships and those measured experimentally.
(4) In normal seminal vesicle, the reaction product was apparently more abundant in columnar and basal cells than in other cell types.
(5) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(6) In contrast, in primordial follicles, FSH was restricted to the germ cell but was present in both the oocyte cytoplasm and germinal vesicle.
(7) In fact, the distribution of [3H]oleate between plasma membranes and unilamellar vesicles of lipids extracted from these membranes was in favor of the lipids, indicating the absence of a detectable amount of binding to a putative fatty acid binding protein in plasma membranes.
(8) This value may be compared to a Kd of 7.3 pM obtained by the same method for the interaction of DF-VIIa with TF1-263 reconstituted into phosphatidylcholine vesicles.
(9) This is interpreted to be a consequence of the adsorption of Ca2+ on the vesicle bilayers.
(10) The results suggest that AH5183 does not bind to the ACh transporter recognition site on the outside of the vesicle membrane, and thus it might inhibit allosterically.
(11) Although the brain AP50 is prominently phosphorylated by an endogenous protein kinase in isolated coated vesicle preparations, the neuronal AP50 was not detectably phosphorylated in intact cells as assessed by two-dimensional non-equilibrium pH gradient gel electrophoresis of labeled cells dissolved directly in SDS-containing buffers.
(12) Interaction of viable macrophages with cationic particles at 37 degrees C resulted in their "internalization" within vesicles and coated pits and a closer apposition between many segments of plasmalemma than with neutral or anionic substances.
(13) The toxins preferentially attenuate a slow phase of KCl-evoked glutamate release which may be associated with synaptic vesicle mobilization.
(14) In vitro studies indicate that dendritic cells only process proteins for a short period of time, when the rate of synthesis of MHC products and content of acidic endocytic vesicles are high.
(15) The latter findings reinforce the concept that in pathologic states associated with cerebral oedema, pinocytotic vesicles fuse to form transendothelial channels which transport plasma proteins into brain.
(16) By contrast, techniques that involved collection of OM vesicles were successful in isolating OM of B. catarrhalis.
(17) It is thus probable that secondary lysosomes become part of the macrophage vesicle.
(18) The response is dose dependent for LPA concentrations from 10(-8) to 10(-3) M. Incubation of oocytes in LPA does not induce germinal vesicle breakdown.
(19) Caffeine and 6-methylaminopurine riboside (6-N-methyladenosine differentially inhibit uptake of radioactivity from adenosine and inosine, and thus the vesicles apparently possess seperate transport systems for uptake of radioactivity from purine nucleosides and from uridine.
(20) The mean length of the seminal vesicles was 2.98 cm.