(1) The purpose of these studies was to better understand the molecular basis of chromosome aberration formation after mitomycin C treatment.
(2) The effects of phenoxyacetic acid herbicides were investigated on the induction of chromosome aberrations in human peripheral lymphocyte cultures in vitro and in lymphocytes of exposed workers in vivo.
(3) Recent studies have shown that an aberration in platelet-derived growth factor gene expression is unlikely to be a factor in proliferation of smooth-muscle cells.
(4) Maximal aberration yields were observed for 2,4-diaminotoluene, 2,6-diaminotoluene and cytosine beta-D-arabinofuranoside from 17 to 21 h, eugenol from 15 to 21 h, cadmium sulfate from 15 to 24 h and 2-aminobiphenyl, from 17 to 24 h. For adriamycin at 1 microM, the % aberrant cells remained elevated throughout the period from 9 to 29 h, while small increases at 0.1 microM ADR were found only at 13 and at 25 h. For most chemicals the maximal aberration yield occurred at a different time for each concentration tested.
(5) Aberrant forms (elongated and twisted) in the vacuole and double virions in the plasma membrane were observed as early as 65 h after infection.
(6) Detailed studies of the between-cell aberration distributions give evidence that positive selection against cells with high aberration frequencies has also occurred in these experiments.
(7) Chromosome aberrations were scored in BHK21 C13 Syrian hamster fibroblasts, exposed to 60Co gamma-rays, 250 kV X-rays, 15 MeV neutrons or neutrons of mean energy 2.1 MeV produced from the 9Be(d,n)10B reaction.
(8) Immense amounts of data about cancer-associated chromosome aberrations have been collected during the last 10 years, and the systematic evaluation of these data has disclosed a number of correlations between chromosome change and neoplastic disease.
(9) ECGs taken routinely over a period of years help differntiate ventricular from supraventricular tachycardias with aberrant conduction.
(10) In three patients treated with photrine cells with aberrative karyotypes ranged within 14-37.5%.
(11) 50 cells at metaphase per animal were scored for chromosomal aberrations.
(12) Thus, in human lymphocytes the frequencies of chromatid aberrations induced by most clastogenic agents were strongly enhanced when caffeine was given during the G2 phase, but little affected by post-treatments with caffeine during the S phase.
(13) Systematic treatment of aberrant subclavian arteries should perhaps be considered when it can be performed during thoracic surgery.
(14) At that time the factor IX users also had milder immune aberrations than the hemophilia A group.
(15) The predominant specific aberrations in gliomas were an over-representation of chromosome 7 (13 cases) and an under-representation of chromosome 10 (16 cases).
(16) It was shown that six pesticides induced a statistically significant increase in the number of chromosomal aberrations: Bi 58 EC, Metasystox (I) forte, Sadofos 30, Nogos 50 EC, Foschlor 25 and Thiodan 35.
(17) Cystic dystrophy of aberrant pancreatic tissue without chronic pancreatitis is a rare disease described by Potet and Duclert in 1970.
(18) Methyl sinapate also increased the frequency of cells with chromosome aberrations in the CHO K-1 cells treated with MMC, 4NQO or UV.
(19) In the exposed group structural chromosome aberrations were found in 2%, while in the control group in 0.9% of analysed metaphases.
(20) These findings indicate structural abnormalities in the secretory apparatus of neuroendocrine cells in dysplastic bronchi and correlate with experimental observations of aberrant hormonal production associated with bronchial dysplasia.
Distort
Definition:
(a.) Distorted; misshapen.
(v. t.) To twist of natural or regular shape; to twist aside physically; as, to distort the limbs, or the body.
(v. t.) To force or put out of the true posture or direction; to twist aside mentally or morally.
(v. t.) To wrest from the true meaning; to pervert; as, to distort passages of Scripture, or their meaning.
Example Sentences:
(1) Findings on plain X-ray of the abdomen, using the usual parameters of psoas and kidney shadows in the Nigerian, indicate that the two communities studied are similar but urinary calculi and urinary tract distortion are significantly more prominent in the community with the higher endemicity of urinary schistosomiasis.
(2) Aside from these characteristic findings of HCC, it was important to reveal the following features for the diagnosis of well differentiated type of small HCC: variable thickening or distortion of trabecular structure in association with nuclear crowding, acinar formation, selective cytoplasmic accumulation of Mallory bodies, nuclear abnormalities consisting of thickening of nucleolus, hepatic cords in close contact with bile ducts or blood vessels, and hepatocytes growing in a fibrous environment.
(3) Mild, significant improvement was noted in one of the hearing components, "attenuation," and an adverse effect was shown on "distortion," owing to noise.
(4) Malema has distorted his leftwing credentials with outrageous behaviour.
(5) Radiologists may encounter patients with fixed dental prostheses that may produce image distortion on MRI scans of the face and jaw.
(6) However, fractional addressing introduces distortion.
(7) The strongest field distortions and attractive forces occurred with 17-7PH stainless steel clips.
(8) This raises questions about police integrity and News International's power to distort procedure in a serious criminal matter.
(9) However, all these characteristics can be distorted if measured by means of a variable-proportion procedure, in which the amount of one primary is held constant while the amount of the other is varied in order to measure threshold.
(10) This could distort the relation between height and forced expiratory volume in 1s (FEV1) as age increases.
(11) The expression of such secondary and tertiary syphilis is commonly masked and distorted by the long-term effects of subcurative doses of antibiotics; in fact, late latent and tertiary syphilis produce symptoms and immunosuppression similar to the profile of AIDS.
(12) These results confirmed that 'punctuated' labeling was not an artefact due to a distortion of the cell's shape by having been dried on glass slides.
(13) The data derived have demonstrated the impairment of the function of the indicated system in the test subjects, associated with sexual behavior impairment in the form of exhibitionism which may form the biological basis for distortion of sexual self-consciousness.
(14) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(15) The latter, which is external and solvent accessible, is associated with a distortion in the alpha-helix centered around Tyr33 which consists of a significant increase in the CO(i-4)-N(i) and CO(i-4)-NH(i) distances relative to those in the rest of the helix, as well as a significant departure in the phi, psi angles of Tyr33 relative to regular helical geometry.
(16) The authors suggest the use of minimal HP filtering so that phase-shift distortion is minimized and a larger response amplitude can be recorded.
(17) Fields said: "The assertions that Tom Cruise likened making a movie to being at war in Afghanistan is a gross distortion of the record... What Tom said, laughingly, was that sometimes, 'That's what it feels like.'"
(18) Therapeutic application of drugs containing propylene glycol 1.2 as a solvent may distort the results of forensic chemical detection of ethylene glycol from its oxidation products.
(19) When a meridional-size lens is used to provide magnification in the horizonal meridan for one eye the resulting stereopsis distortion is readily accounted for in the terms of the binocular disparity caused by changed angular relations.
(20) Synchronization of spontaneous otoacoustic emissions to a cubic distortion frequency fs = 2f1-f2 has been studied.