(a.) Sharp at the end; ending in a sharp point; pointed; -- opposed to blunt or obtuse; as, an acute angle; an acute leaf.
(a.) Having nice discernment; perceiving or using minute distinctions; penetrating; clever; shrewd; -- opposed to dull or stupid; as, an acute observer; acute remarks, or reasoning.
(a.) Having nice or quick sensibility; susceptible to slight impressions; acting keenly on the senses; sharp; keen; intense; as, a man of acute eyesight, hearing, or feeling; acute pain or pleasure.
(a.) High, or shrill, in respect to some other sound; -- opposed to grave or low; as, an acute tone or accent.
(a.) Attended with symptoms of some degree of severity, and coming speedily to a crisis; -- opposed to chronic; as, an acute disease.
(v. t.) To give an acute sound to; as, he acutes his rising inflection too much.
Example Sentences:
(1) In January 2011, the Nobel peace prize laureate was admitted to a Johannesburg hospital for what officials initially described as tests but what turned out to be an acute respiratory infection .
(2) It is concluded that acute renal denervation augments the pressure diuresis that follows carotid occlusion.
(3) Ethanol and L-ethionine induce acute steatosis without necrosis, whereas azaserine, carbon tetrachloride, and D-galactosamine are known to produce steatosis with varying degrees of hepatic necrosis.
(4) IgE-mediated acute systemic reactions to penicillin continue to be an important clinical problem.
(5) The cumulative incidence of grade II and III acute GVHD in the 'low dose' cyclosporin group was 42% compared to 51% in the 'standard dose' group (P = 0.60).
(6) A 66-year-old woman with acute idiopathic polyneuritis (Landry-Guillain-Barré [LGB] syndrome) had normal extraocular movements, but her pupils did not react to light or accommodation.
(7) After a period on fat-rich diet the patient's physical fitness was increased and the recovery period after the acute load was shorter.
(8) It was concluded that metoclopramide and dexamethasone showed an excellent antiemetic effect on acute drug-induced emesis, as well as on delayed emesis, induced by cisplatin.
(9) The results suggest that RPE cannot be used reliably as a surrogate for direct pulse measurement in exercise training of persons with acute dysvascular amputations.
(10) Statistically significant differences were found mainly in the randomized trial, where during the first and second years, respectively, adenoidectomy subjects had 47% and 37% less time with otitis media than control subjects and 28% and 35% fewer suppurative (acute) episodes than control subjects.
(11) Tumour necrosis factor (TNF), a polypeptide produced by mononuclear phagocytes, has been implicated as an important mediator of inflammatory processes and of clinical manifestations in acute infectious diseases.
(12) During the procedure, acute respiratory failure developed as a result of tracheal obstruction.
(13) Four patients with acute brucellosis are described, none of whom had any connexion with farming or milk industry, the source of infection being different in each case.
(14) The leukemic T-cells in two patients with chronic lymphocytic leukemia (CLL) had specific features of large granular lymphocytes (LGL), and those in two patients with acute lymphocytic leukemia (ALL) had L2 morphologic characteristics.
(15) The acute effect of alcohol manifested itself by decreasing mitochondrial respiration, compensated by increased glycolytic activity of the myocardium so that myocardial energy phosphate concentration remained unchanged.
(16) The introduction of intravenous, high-dose thrombolytic therapy during a brief period has markedly reduced mortality of patients with acute myocardial infarction.
(17) The younger patients more often experienced an acute arthritis with sacroiliitis resembling a reactive disease.
(18) All five individuals appeared to have acute C. pneumoniae infection as determined by results of serologic tests (titers of IgM antibody for all individuals were greater than or equal to 1:16).
(19) The results clearly show that the acute hyperthermia of unrestrained rats induced by either peripheral or central injections of morphine is not caused by activation of the pituitary-adrenal axis.
(20) The effect of hypertension, hyperlipidemia, and the combination of both on acute and chronic myocardial ischemia were evaluated in a total of 30 male rabbits.
Severe
Definition:
(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.