(n.) Doing; trouble; difficulty; troublesome business; fuss; bustle; as, to make a great ado about trifles.
Example Sentences:
(1) This inhibition was correlated with the enhanced Ado toxicity, suggesting inhibition of methylation as a possible causal factor for the great increase in Ado sensitivity.
(2) S-Adenosyl-L-methionine (Ado-met) administration to rats significantly improved liver necrosis induced by thioacetamide (TAA) as evidenced by reduction of TAA-elevated catalytic activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALAT).
(3) Apparent Michaelis (Km) constants for the two cosubstrates for the reaction, 6-MP and S-adenosyl-L-methionine (Ado-Met), in mouse kidney were 7.0 X 10(-4) M and 2.4 X 10(-6) M respectively.
(4) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(5) Both 20 microM nitrobenzylthioinosine (NBMPR), an inhibitor of the purine nucleoside carrier, and 0.1 mM alpha,beta-methylene adenosine diphosphate (AOPCP), an inhibitor of 5'-nucleotidase activity, attenuate DNP-stimulated ADO release (NBMPR by 62% and ADOCP by 76%).
(6) The effect of adenosine (ADO) on the recovery of cellular adenine nucleotides (AN) was evaluated in the cultured cells deprived of oxygen and substrates (ischemia) and in nonischemic cells (control).
(7) The brain dialysis technique was used to (a) deliver drugs locally to brain tissue, (b) estimate cerebral ISF ADO levels, and (c) measure local CBF (hydrogen clearance).
(8) The present experiments were designed to examine the effects of Ado and adenosine analogues on net chloride (JCl) and bicarbonate (JHCO3) absorption by the isolated, perfused MTAL of the rat.
(9) In other tissues, such as adipose and skeletal muscle, much attention has focused on the role of ADO as a metabolic regulator of the actions of insulin.
(10) Adenosine (ADO) in low micromolar levels and hypoxanthine (HYP) in millimolar levels have been shown to inhibit maturation of cumulus-enclosed oocytes.
(11) Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions.
(12) These results suggest that the beta-adrenergic stimulation the interstitial level of ADO in the heart increases to levels that are sufficient to manifest its antiadrenergic effects.
(13) In an experiment with tRNAPhe which is a substrate for a single, namely m5C methylase, the type of inhibition of this methylase by S-Cyd-Hcy was revealed; it was found to be non-competitive with respect to S-Ado-Met, and the S-Cyd-Hcy concentration reducing the methylation by 50 percent was 1.2-10(-4) M.
(14) He also appeared in a number of Branagh's films including Much Ado About Nothing (1993) and as Polonius in Hamlet (1996).
(15) These results provide indirect evidence that in enterocytes methylmalonyl-CoA mutase, the coenzyme of which is Ado-Cbl, is located in the mitochondrial fraction and that methionine synthetase, the coenzyme of which is Me-Cbl, is located in the sap fraction.
(16) Now Michael, what was the word I just said?” I told her the word was “Monday” and, with no more ado, she returned to her desk and clattered something out on her computer.
(17) Nevertheless, the antiviral action of F-C-Ado appears to be targeted at AdoHcy hydrolase.
(18) Low (nM) amounts of the Ado agonists inhibited cAMP formation in both cell types.
(19) This was confirmed by the comparison of the rates of hydrolysis of m7Guo5'PPP5'Ado by the enzyme in the presence of various nucleotides.
(20) He owed his late-flourishing film career to Branagh, appearing in a string of his movies: as Bardolph in Henry V (1989), Leonato in Much Ado About Nothing (1993), the old blind man in Mary Shelley's Frankenstein (1994), a cantankerous old thespian in A Midwinter's Tale (1995), Polonius in Hamlet (1996) and Sir Nathaniel in the musical Love's Labour's Lost (2000).
Cut
Definition:
(imp. & p. p.) of Cut
(v. t.) To separate the parts of with, or as with, a sharp instrument; to make an incision in; to gash; to sever; to divide.
(v. t.) To sever and cause to fall for the purpose of gathering; to hew; to mow or reap.
(v. t.) To sever and remove by cutting; to cut off; to dock; as, to cut the hair; to cut the nails.
(v. t.) To castrate or geld; as, to cut a horse.
(v. t.) To form or shape by cutting; to make by incision, hewing, etc.; to carve; to hew out.
(v. t.) To wound or hurt deeply the sensibilities of; to pierce; to lacerate; as, sarcasm cuts to the quick.
(v. t.) To intersect; to cross; as, one line cuts another at right angles.
(v. t.) To refuse to recognize; to ignore; as, to cut a person in the street; to cut one's acquaintance.
(v. t.) To absent one's self from; as, to cut an appointment, a recitation. etc.
(v. i.) To do the work of an edged tool; to serve in dividing or gashing; as, a knife cuts well.
(v. i.) To admit of incision or severance; to yield to a cutting instrument.
(v. i.) To perform the operation of dividing, severing, incising, intersecting, etc.; to use a cutting instrument.
(v. i.) To make a stroke with a whip.
(v. i.) To interfere, as a horse.
(v. i.) To move or make off quickly.
(v. i.) To divide a pack of cards into two portion to decide the deal or trump, or to change the order of the cards to be dealt.
(n.) An opening made with an edged instrument; a cleft; a gash; a slash; a wound made by cutting; as, a sword cut.
(n.) A stroke or blow or cutting motion with an edged instrument; a stroke or blow with a whip.
(n.) That which wounds the feelings, as a harsh remark or criticism, or a sarcasm; personal discourtesy, as neglecting to recognize an acquaintance when meeting him; a slight.
(n.) A notch, passage, or channel made by cutting or digging; a furrow; a groove; as, a cut for a railroad.
(n.) The surface left by a cut; as, a smooth or clear cut.
(n.) A portion severed or cut off; a division; as, a cut of beef; a cut of timber.
(n.) An engraved block or plate; the impression from such an engraving; as, a book illustrated with fine cuts.
(n.) The act of dividing a pack cards.
(n.) The right to divide; as, whose cut is it?
(n.) Manner in which a thing is cut or formed; shape; style; fashion; as, the cut of a garment.
(n.) A common work horse; a gelding.
(n.) The failure of a college officer or student to be present at any appointed exercise.
(n.) A skein of yarn.
(a.) Gashed or divided, as by a cutting instrument.
(a.) Formed or shaped as by cutting; carved.
(a.) Overcome by liquor; tipsy.
Example Sentences:
(1) A subsample of patients scoring over the recommended threshold (five or above) on the general health questionnaire were interviewed by the psychiatrist to compare the case detection of the general practitioner, an independent psychiatric assessment and the 28-item general health questionnaire at two different cut-off scores.
(2) McDonald said cutting better deals with suppliers and improving efficiency as well as raising some prices had only partly offset the impact of sterling’s fall against the dollar.
(3) The playing fields on which all those players began their journeys have been underfunded for years and are now facing a renewed crisis because of cuts to local authority budgets.
(4) Finally, the automatized measurement system cuts the time spent by a factor of more than five.
(5) We could do with similar action to cut out botnets and spam, but there aren't any big-money lobbyists coming to Mandelson pleading loss of business through those.
(6) It comes as the museum is transforming itself in the wake of major cuts in its government funding and looking more towards private-sector funding, a move that has caused some unease about its future direction.
(7) Chromatolysis and swelling of the cell bodies of cut axons are more prolonged than after optic nerve section and resolve in more central regions of retina first.
(8) Guardian Australia reported last week that morale at the national laboratory had fallen dramatically, with one in three staff “seriously considering” leaving their jobs in the wake of the cuts.
(9) It is proposed that this "zipper-like" mechanism represents the normal cutting process of the septum during cell separation.
(10) Limitations include the facts that the tracer inventory requires a minimal survival period, can only be done postmortem, and has low resolution for cuts of the vagal hepatic branch.
(11) White lesions (NRL) against a gray background on cut section of brain increase in size with increasing time of arrest.
(12) She was clearly elected on a pledge not to cut school funding and that’s exactly what is happening,” Corbyn said.
(13) We are in the middle of the third year of huge cuts in acute hospitals' budgets," said Porter.
(14) This includes cutting corporation tax to 20%, the lowest in the G20, and improving our visa arrangements with a new mobile visa service up and running in Beijing and Shanghai and a new 24-hour visa service on offer from next summer.
(15) Leaders of Tory local government are preparing radical proposals for minimum 10% cuts in public spending in the search for savings.
(16) Size comparison of the newly discovered Msp I fragment with a restriction map of the apolipoprotein A-I gene revealed that most likely the cutting site at the 5'-end of the normally seen 673 bp fragment is lost giving rise to the observed 719 bp Msp I fragment.
(17) The drugs were moderately potent inhibitors of both E. electricus and C. elegans acetylcholinesterase but at concentrations too high to account for their abilities to contract cut worms.
(18) Although various micronutrients (vitamins and trace elements) have also been found to have either a positive or negative association, findings were more clear-cut for the different food items contributing the micronutrients than for the specific micronutrients themselves.
(19) On taking office Lansley admitted this was not a deep enough cut.
(20) "If you are not prepared to learn English, your benefits will be cut," he said.