(n.) Doing; trouble; difficulty; troublesome business; fuss; bustle; as, to make a great ado about trifles.
Example Sentences:
(1) This inhibition was correlated with the enhanced Ado toxicity, suggesting inhibition of methylation as a possible causal factor for the great increase in Ado sensitivity.
(2) S-Adenosyl-L-methionine (Ado-met) administration to rats significantly improved liver necrosis induced by thioacetamide (TAA) as evidenced by reduction of TAA-elevated catalytic activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALAT).
(3) Apparent Michaelis (Km) constants for the two cosubstrates for the reaction, 6-MP and S-adenosyl-L-methionine (Ado-Met), in mouse kidney were 7.0 X 10(-4) M and 2.4 X 10(-6) M respectively.
(4) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(5) Both 20 microM nitrobenzylthioinosine (NBMPR), an inhibitor of the purine nucleoside carrier, and 0.1 mM alpha,beta-methylene adenosine diphosphate (AOPCP), an inhibitor of 5'-nucleotidase activity, attenuate DNP-stimulated ADO release (NBMPR by 62% and ADOCP by 76%).
(6) The effect of adenosine (ADO) on the recovery of cellular adenine nucleotides (AN) was evaluated in the cultured cells deprived of oxygen and substrates (ischemia) and in nonischemic cells (control).
(7) The brain dialysis technique was used to (a) deliver drugs locally to brain tissue, (b) estimate cerebral ISF ADO levels, and (c) measure local CBF (hydrogen clearance).
(8) The present experiments were designed to examine the effects of Ado and adenosine analogues on net chloride (JCl) and bicarbonate (JHCO3) absorption by the isolated, perfused MTAL of the rat.
(9) In other tissues, such as adipose and skeletal muscle, much attention has focused on the role of ADO as a metabolic regulator of the actions of insulin.
(10) Adenosine (ADO) in low micromolar levels and hypoxanthine (HYP) in millimolar levels have been shown to inhibit maturation of cumulus-enclosed oocytes.
(11) Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions.
(12) These results suggest that the beta-adrenergic stimulation the interstitial level of ADO in the heart increases to levels that are sufficient to manifest its antiadrenergic effects.
(13) In an experiment with tRNAPhe which is a substrate for a single, namely m5C methylase, the type of inhibition of this methylase by S-Cyd-Hcy was revealed; it was found to be non-competitive with respect to S-Ado-Met, and the S-Cyd-Hcy concentration reducing the methylation by 50 percent was 1.2-10(-4) M.
(14) He also appeared in a number of Branagh's films including Much Ado About Nothing (1993) and as Polonius in Hamlet (1996).
(15) These results provide indirect evidence that in enterocytes methylmalonyl-CoA mutase, the coenzyme of which is Ado-Cbl, is located in the mitochondrial fraction and that methionine synthetase, the coenzyme of which is Me-Cbl, is located in the sap fraction.
(16) Now Michael, what was the word I just said?” I told her the word was “Monday” and, with no more ado, she returned to her desk and clattered something out on her computer.
(17) Nevertheless, the antiviral action of F-C-Ado appears to be targeted at AdoHcy hydrolase.
(18) Low (nM) amounts of the Ado agonists inhibited cAMP formation in both cell types.
(19) This was confirmed by the comparison of the rates of hydrolysis of m7Guo5'PPP5'Ado by the enzyme in the presence of various nucleotides.
(20) He owed his late-flourishing film career to Branagh, appearing in a string of his movies: as Bardolph in Henry V (1989), Leonato in Much Ado About Nothing (1993), the old blind man in Mary Shelley's Frankenstein (1994), a cantankerous old thespian in A Midwinter's Tale (1995), Polonius in Hamlet (1996) and Sir Nathaniel in the musical Love's Labour's Lost (2000).
Fuss
Definition:
(n.) A tumult; a bustle; unnecessary or annoying ado about trifles.
(n.) One who is unduly anxious about trifles.
(v. i.) To be overbusy or unduly anxious about trifles; to make a bustle or ado.
Example Sentences:
(1) But insiders say the industry has been watering down the proposals, and no amount of fussing over the detail is going to get round the central point.
(2) But minutes after the final whistle, 76% of respondents to a Corriere della Sport online poll were blaming Lippi and in the post-match press conference the man himself was quick to take the blame, appearing to be anxiously awaiting the moment he can disappear quietly from the scene to be replaced by the Fiorentina manager, Cesare Prandelli, a switch decided with little fuss and no media debate just before the World Cup.
(3) The decade of the Delors presidency from 1985 saw further steps towards integration taken with relatively little fuss.
(4) Mel The squirrel in series two, with the balls [incidental footage of a squirrel caused a fuss on social media in 2011].
(5) But the Depp dog furore is a perfect example of the different approach Joyce will take to leading the Nationals – the rural-based minor party in the governing Coalition that has in recent years had a series of gentlemanly leaders who, wherever possible, have settled differences with their Coalition parties quietly, created public fusses only rarely, and international incidents never.
(6) It is now on sale in the store after publisher Europa Editions kicked up a fuss.
(7) If a contractor was involved in an incident which caused a fuss, they were whisked out of the country by their company.
(8) I don't see what all the fuss is about Germany v England.
(9) Such was its challenge that, when it was found in the library of a school run by the Inner London Education Authority in 1986, the fuss exploded and the book was subsequently cited as one of the spurs to the controversial Section 28 of the Local Government Act of 1988.
(10) He has long been called a "rock star president" and there was lots of fuss in Thailand preceding US president Barack Obama's first visit to Bangkok on Sunday.
(11) Outside, there’s no sign of life except one bearded oaf on a chopper and a kid at the back door, holding a picture of Hot Fuss-era Brandon Flowers , praying for a brief encounter.
(12) Stepping back from the fuss, it is worth thinking about whether the project's aims make sense.
(13) Her parents, a midwife and a retired fireman, said they were proud of their supremely focussed, "no fuss" daughter.
(14) He attracts controversy in February while denying Jermain Defoe elbowed Nicolás Otamendi, saying foreign players “make a big fuss of it.
(15) The fuss over who should pay for this scheme has, rather sadly in my view, overshadowed its goals.
(16) Perhaps air pollution hasn’t been solved because no one makes a fuss: scarier than the smog in Delhi , Kolkata and London is the stoicism of residents for whom bad air has become part of daily life.
(17) To this end it is they, not politicians, who need to be making a fuss about full-face veils and the need to phase them out.
(18) Some case notes make harrowing reading: cells occupied by disabled prisoners with no wall bars and inmates having to drag themselves across the floor and falling frequently; PAS "having to make a fuss" to get inmates supplied with basic needs, such as walking sticks, which are then taken away when a prisoner moves prison; and an incontinent prisoner with mental health problems sleeping naked on a urine-soaked mattress.
(19) Why quite such a fuss when nothing much actually happened?
(20) The infant's state was recorded on a check-list every 10 sec using the following categories for sleep and wakefulness: Quiet Sleep A, Quiet Sleep B, Active Sleep Without REM, Active Sleep With REM, Active Sleep With Dense REM, Drowsy, Alert Inactivity, WAKING Activity, Fussing, Crying, and Indefinite State.