(n.) Doing; trouble; difficulty; troublesome business; fuss; bustle; as, to make a great ado about trifles.
Example Sentences:
(1) This inhibition was correlated with the enhanced Ado toxicity, suggesting inhibition of methylation as a possible causal factor for the great increase in Ado sensitivity.
(2) S-Adenosyl-L-methionine (Ado-met) administration to rats significantly improved liver necrosis induced by thioacetamide (TAA) as evidenced by reduction of TAA-elevated catalytic activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALAT).
(3) Apparent Michaelis (Km) constants for the two cosubstrates for the reaction, 6-MP and S-adenosyl-L-methionine (Ado-Met), in mouse kidney were 7.0 X 10(-4) M and 2.4 X 10(-6) M respectively.
(4) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(5) Both 20 microM nitrobenzylthioinosine (NBMPR), an inhibitor of the purine nucleoside carrier, and 0.1 mM alpha,beta-methylene adenosine diphosphate (AOPCP), an inhibitor of 5'-nucleotidase activity, attenuate DNP-stimulated ADO release (NBMPR by 62% and ADOCP by 76%).
(6) The effect of adenosine (ADO) on the recovery of cellular adenine nucleotides (AN) was evaluated in the cultured cells deprived of oxygen and substrates (ischemia) and in nonischemic cells (control).
(7) The brain dialysis technique was used to (a) deliver drugs locally to brain tissue, (b) estimate cerebral ISF ADO levels, and (c) measure local CBF (hydrogen clearance).
(8) The present experiments were designed to examine the effects of Ado and adenosine analogues on net chloride (JCl) and bicarbonate (JHCO3) absorption by the isolated, perfused MTAL of the rat.
(9) In other tissues, such as adipose and skeletal muscle, much attention has focused on the role of ADO as a metabolic regulator of the actions of insulin.
(10) Adenosine (ADO) in low micromolar levels and hypoxanthine (HYP) in millimolar levels have been shown to inhibit maturation of cumulus-enclosed oocytes.
(11) Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions.
(12) These results suggest that the beta-adrenergic stimulation the interstitial level of ADO in the heart increases to levels that are sufficient to manifest its antiadrenergic effects.
(13) In an experiment with tRNAPhe which is a substrate for a single, namely m5C methylase, the type of inhibition of this methylase by S-Cyd-Hcy was revealed; it was found to be non-competitive with respect to S-Ado-Met, and the S-Cyd-Hcy concentration reducing the methylation by 50 percent was 1.2-10(-4) M.
(14) He also appeared in a number of Branagh's films including Much Ado About Nothing (1993) and as Polonius in Hamlet (1996).
(15) These results provide indirect evidence that in enterocytes methylmalonyl-CoA mutase, the coenzyme of which is Ado-Cbl, is located in the mitochondrial fraction and that methionine synthetase, the coenzyme of which is Me-Cbl, is located in the sap fraction.
(16) Now Michael, what was the word I just said?” I told her the word was “Monday” and, with no more ado, she returned to her desk and clattered something out on her computer.
(17) Nevertheless, the antiviral action of F-C-Ado appears to be targeted at AdoHcy hydrolase.
(18) Low (nM) amounts of the Ado agonists inhibited cAMP formation in both cell types.
(19) This was confirmed by the comparison of the rates of hydrolysis of m7Guo5'PPP5'Ado by the enzyme in the presence of various nucleotides.
(20) He owed his late-flourishing film career to Branagh, appearing in a string of his movies: as Bardolph in Henry V (1989), Leonato in Much Ado About Nothing (1993), the old blind man in Mary Shelley's Frankenstein (1994), a cantankerous old thespian in A Midwinter's Tale (1995), Polonius in Hamlet (1996) and Sir Nathaniel in the musical Love's Labour's Lost (2000).
Hullabaloo
Definition:
(n.) A confused noise; uproar; tumult.
Example Sentences:
(1) Along the way, they will enjoy a vegetarian barbecue or two in the evenings, as well as something called a Hullabaloo Quire (songs of protest and celebration from around the world).
(2) Immediately a hullabaloo followed, with critics accused of being ungrateful by those in favour of what the government offered.
(3) What we have actually seen during this parliament is a government successfully making itself irrelevant while creating a huge, empty hullabaloo over how it's doing the opposite.
(4) She felt hollow and lifeless and compared herself to the calm centre of a tornado, "moving dully along in the middle of the surrounding hullabaloo", she writes.
(5) But amid all the hullabaloo, it is worth remembering that for millions of employees, nothing is changing.
(6) But none of these events, not even Andy Murray reaching the final of the Australian Open, has generated half as much hullabaloo as the appearance on a stage in San Francisco of an ill-shaven old boy in jeans and sneakers to present his latest commercial product to the world.
(7) We have had a hullabaloo over a new 10% tax threshold and abolishing a new 50p one .
(8) Another library that opened to great hullabaloo is the Idea Store in Whitechapel, designed by David Adjaye and operated by Tower Hamlets.
(9) That hullabaloo in Belo Horizonte last night knocked the earth clean off its axis, but the space-time continuum appears to have remained in one piece, just about, and so kick off is at: 5pm at the Arena de São Paulo , 5pm in Buenos Aires, 10pm in Amsterdam, 9pm in London.
(10) Leading to this Friday’s hullabaloo was a YouTube round-the-world event – which ends on Thursday night – where the new toys were unboxed live in 15 different cities over an 18-hour span.
(11) Hanging signs of Lombard Street, the City Lombard Street, amid the hullabaloo of the City, is one of the few places in London where 17th- and 18th-century-style shop signs survive in all their gilt glory, jutting from buildings on wrought-iron brackets, creaking and groaning in the wind.
(12) With this hullabaloo, you have to wonder if Chuck hasn't felt rather let down by his bandmates over the years.
(13) AS far as I can gather, despite the annual hullabaloo over the team's clobber, only team in more than a century of Cup finals has worn an even slightly interesting suit (Liverpool's white ensemble, of course).
(14) Not that the Mayans are to blame for the hullabaloo over 21 December 2012.
(15) I listened in vain for Blackie's name to be called, and then to all the hullabaloo over a certain Jack Russell terrier named Uggie . "
(16) Outside the fashion shows is the hullabaloo frenzy – photographers go crazy and everyone's trying to get pictures for their blog or website.