(n.) Doing; trouble; difficulty; troublesome business; fuss; bustle; as, to make a great ado about trifles.
Example Sentences:
(1) This inhibition was correlated with the enhanced Ado toxicity, suggesting inhibition of methylation as a possible causal factor for the great increase in Ado sensitivity.
(2) S-Adenosyl-L-methionine (Ado-met) administration to rats significantly improved liver necrosis induced by thioacetamide (TAA) as evidenced by reduction of TAA-elevated catalytic activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALAT).
(3) Apparent Michaelis (Km) constants for the two cosubstrates for the reaction, 6-MP and S-adenosyl-L-methionine (Ado-Met), in mouse kidney were 7.0 X 10(-4) M and 2.4 X 10(-6) M respectively.
(4) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(5) Both 20 microM nitrobenzylthioinosine (NBMPR), an inhibitor of the purine nucleoside carrier, and 0.1 mM alpha,beta-methylene adenosine diphosphate (AOPCP), an inhibitor of 5'-nucleotidase activity, attenuate DNP-stimulated ADO release (NBMPR by 62% and ADOCP by 76%).
(6) The effect of adenosine (ADO) on the recovery of cellular adenine nucleotides (AN) was evaluated in the cultured cells deprived of oxygen and substrates (ischemia) and in nonischemic cells (control).
(7) The brain dialysis technique was used to (a) deliver drugs locally to brain tissue, (b) estimate cerebral ISF ADO levels, and (c) measure local CBF (hydrogen clearance).
(8) The present experiments were designed to examine the effects of Ado and adenosine analogues on net chloride (JCl) and bicarbonate (JHCO3) absorption by the isolated, perfused MTAL of the rat.
(9) In other tissues, such as adipose and skeletal muscle, much attention has focused on the role of ADO as a metabolic regulator of the actions of insulin.
(10) Adenosine (ADO) in low micromolar levels and hypoxanthine (HYP) in millimolar levels have been shown to inhibit maturation of cumulus-enclosed oocytes.
(11) Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions.
(12) These results suggest that the beta-adrenergic stimulation the interstitial level of ADO in the heart increases to levels that are sufficient to manifest its antiadrenergic effects.
(13) In an experiment with tRNAPhe which is a substrate for a single, namely m5C methylase, the type of inhibition of this methylase by S-Cyd-Hcy was revealed; it was found to be non-competitive with respect to S-Ado-Met, and the S-Cyd-Hcy concentration reducing the methylation by 50 percent was 1.2-10(-4) M.
(14) He also appeared in a number of Branagh's films including Much Ado About Nothing (1993) and as Polonius in Hamlet (1996).
(15) These results provide indirect evidence that in enterocytes methylmalonyl-CoA mutase, the coenzyme of which is Ado-Cbl, is located in the mitochondrial fraction and that methionine synthetase, the coenzyme of which is Me-Cbl, is located in the sap fraction.
(16) Now Michael, what was the word I just said?” I told her the word was “Monday” and, with no more ado, she returned to her desk and clattered something out on her computer.
(17) Nevertheless, the antiviral action of F-C-Ado appears to be targeted at AdoHcy hydrolase.
(18) Low (nM) amounts of the Ado agonists inhibited cAMP formation in both cell types.
(19) This was confirmed by the comparison of the rates of hydrolysis of m7Guo5'PPP5'Ado by the enzyme in the presence of various nucleotides.
(20) He owed his late-flourishing film career to Branagh, appearing in a string of his movies: as Bardolph in Henry V (1989), Leonato in Much Ado About Nothing (1993), the old blind man in Mary Shelley's Frankenstein (1994), a cantankerous old thespian in A Midwinter's Tale (1995), Polonius in Hamlet (1996) and Sir Nathaniel in the musical Love's Labour's Lost (2000).
Secure
Definition:
(a.) Free from fear, care, or anxiety; easy in mind; not feeling suspicion or distrust; confident.
(a.) Overconfident; incautious; careless; -- in a bad sense.
(a.) Confident in opinion; not entertaining, or not having reason to entertain, doubt; certain; sure; -- commonly with of; as, secure of a welcome.
(a.) Net exposed to danger; safe; -- applied to persons and things, and followed by against or from.
(v. t.) To make safe; to relieve from apprehensions of, or exposure to, danger; to guard; to protect.
(v. t.) To put beyond hazard of losing or of not receiving; to make certain; to assure; to insure; -- frequently with against or from, rarely with of; as, to secure a creditor against loss; to secure a debt by a mortgage.
(v. t.) To make fast; to close or confine effectually; to render incapable of getting loose or escaping; as, to secure a prisoner; to secure a door, or the hatches of a ship.
(v. t.) To get possession of; to make one's self secure of; to acquire certainly; as, to secure an estate.
Example Sentences:
(1) He added: "There is a rigorous review process of applications submitted by the executive branch, spearheaded initially by five judicial branch lawyers who are national security experts and then by the judges, to ensure that the court's authorizations comport with what the applicable statutes authorize."
(2) One hundred and twenty-seven states have said with common voice that their security is directly threatened by the 15,000 nuclear weapons that exist in the arsenals of nine countries, and they are demanding that these weapons be prohibited and abolished.
(3) Power urges the security council to "take the kind of credible, binding action warranted."
(4) The west Africa Ebola epidemic “Few global events match epidemics and pandemics in potential to disrupt human security and inflict loss of life and economic and social damage,” he said.
(5) The so-called literati aren't insular – this from a woman who ran the security service – but we aren't going to apologise for what we believe in either.
(6) Solely infectious waste become removed hospital-intern and -extern on conditions of hygienic prevention, namely through secure packing during the transport, combustion or desinfection.
(7) The remaining grafts appeared to be incorporated securely, as determined by radiographic examination.
(8) But because current donor contributions are not sufficient to cover the thousands of schools in need of security, I will ask in the commons debate that the UK government allocates more.
(9) "Especially at a time when they are turning down voluntary requests and securing the positions of senior managers."
(10) Huhne increased the Lib Dems' majority to 3,864 in 2010, securing 24,966 compared with the Conservatives' 21,102, Labour's 5,153 and Ukip's 1,933.
(11) This is not for the most part revolutionary.” Trump has made some of his least ideological picks in the area of national security and foreign policy.
(12) Based on the results of the Community AIM Exploratory Action, further collaborative work is required at EEC level to create an Integrated Health Information Environment (IHE) allowing essentially for integration, modularity and security.
(13) Pyongyang also called the UN security council an "ugly product of American-led international pressure".
(14) To confront this evil – and defeat it, standing together for our values, for our security, for our prosperity.” Merkel gave a strong endorsement of Cameron’s reform strategy, saying that Britain’s demands were “not just understandable, but worthy of support”.
(15) The fact that the security service was in possession of and retained the copy tape until the early summer of 1985 and did not bring it to the attention of Mr Stalker is wholly reprehensible,” he wrote.
(16) The results indicate that the legislated increase in the age of eligibility for full Social Security benefits beginning in the 21st century will have relatively small effects on the ages of retirement and benefit acceptance.
(17) We have reported on a simple and secure method of tying up hair during transplantation surgery for alopecia.
(18) Chapman and the other "illegals" – sleeper agents without diplomatic cover – seem to have done little to harm American national security.
(19) Many organisations choose not to affiliate their aid work with the UN, particularly in conflict situations, where the organisation is not always seen either as neutral or separate from the work of the UN security council.
(20) Van Rompuy and Ashton got their jobs at the same time as a result of the Lisbon treaty, which created the posts of president of the European council and high representative for foreign and security policy.