(n.) Doing; trouble; difficulty; troublesome business; fuss; bustle; as, to make a great ado about trifles.
Example Sentences:
(1) This inhibition was correlated with the enhanced Ado toxicity, suggesting inhibition of methylation as a possible causal factor for the great increase in Ado sensitivity.
(2) S-Adenosyl-L-methionine (Ado-met) administration to rats significantly improved liver necrosis induced by thioacetamide (TAA) as evidenced by reduction of TAA-elevated catalytic activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALAT).
(3) Apparent Michaelis (Km) constants for the two cosubstrates for the reaction, 6-MP and S-adenosyl-L-methionine (Ado-Met), in mouse kidney were 7.0 X 10(-4) M and 2.4 X 10(-6) M respectively.
(4) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(5) Both 20 microM nitrobenzylthioinosine (NBMPR), an inhibitor of the purine nucleoside carrier, and 0.1 mM alpha,beta-methylene adenosine diphosphate (AOPCP), an inhibitor of 5'-nucleotidase activity, attenuate DNP-stimulated ADO release (NBMPR by 62% and ADOCP by 76%).
(6) The effect of adenosine (ADO) on the recovery of cellular adenine nucleotides (AN) was evaluated in the cultured cells deprived of oxygen and substrates (ischemia) and in nonischemic cells (control).
(7) The brain dialysis technique was used to (a) deliver drugs locally to brain tissue, (b) estimate cerebral ISF ADO levels, and (c) measure local CBF (hydrogen clearance).
(8) The present experiments were designed to examine the effects of Ado and adenosine analogues on net chloride (JCl) and bicarbonate (JHCO3) absorption by the isolated, perfused MTAL of the rat.
(9) In other tissues, such as adipose and skeletal muscle, much attention has focused on the role of ADO as a metabolic regulator of the actions of insulin.
(10) Adenosine (ADO) in low micromolar levels and hypoxanthine (HYP) in millimolar levels have been shown to inhibit maturation of cumulus-enclosed oocytes.
(11) Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions.
(12) These results suggest that the beta-adrenergic stimulation the interstitial level of ADO in the heart increases to levels that are sufficient to manifest its antiadrenergic effects.
(13) In an experiment with tRNAPhe which is a substrate for a single, namely m5C methylase, the type of inhibition of this methylase by S-Cyd-Hcy was revealed; it was found to be non-competitive with respect to S-Ado-Met, and the S-Cyd-Hcy concentration reducing the methylation by 50 percent was 1.2-10(-4) M.
(14) He also appeared in a number of Branagh's films including Much Ado About Nothing (1993) and as Polonius in Hamlet (1996).
(15) These results provide indirect evidence that in enterocytes methylmalonyl-CoA mutase, the coenzyme of which is Ado-Cbl, is located in the mitochondrial fraction and that methionine synthetase, the coenzyme of which is Me-Cbl, is located in the sap fraction.
(16) Now Michael, what was the word I just said?” I told her the word was “Monday” and, with no more ado, she returned to her desk and clattered something out on her computer.
(17) Nevertheless, the antiviral action of F-C-Ado appears to be targeted at AdoHcy hydrolase.
(18) Low (nM) amounts of the Ado agonists inhibited cAMP formation in both cell types.
(19) This was confirmed by the comparison of the rates of hydrolysis of m7Guo5'PPP5'Ado by the enzyme in the presence of various nucleotides.
(20) He owed his late-flourishing film career to Branagh, appearing in a string of his movies: as Bardolph in Henry V (1989), Leonato in Much Ado About Nothing (1993), the old blind man in Mary Shelley's Frankenstein (1994), a cantankerous old thespian in A Midwinter's Tale (1995), Polonius in Hamlet (1996) and Sir Nathaniel in the musical Love's Labour's Lost (2000).
Worry
Definition:
(v. t.) To harass by pursuit and barking; to attack repeatedly; also, to tear or mangle with the teeth.
(v. t.) To harass or beset with importunity, or with care an anxiety; to vex; to annoy; to torment; to tease; to fret; to trouble; to plague.
(v. t.) To harass with labor; to fatigue.
(v. i.) To feel or express undue care and anxiety; to manifest disquietude or pain; to be fretful; to chafe; as, the child worries; the horse worries.
(n.) A state of undue solicitude; a state of disturbance from care and anxiety; vexation; anxiety; fret; as, to be in a worry.
Example Sentences:
(1) But the position of locum GPs remains worryingly unsure.
(2) I know I have the courage to deal with all the sniping but you worry about the effects on your family."
(3) If Lagarde had been placed under formal investigation in the Tapie case, it would have risked weakening her position and further embarrassing both the IMF and France by heaping more judicial worries on a key figure on the international stage.
(4) In Paris, a foreign ministry spokesman, Romain Nadal, said the French authorities were “fully mobilised to help Serge Atlaoui, whose situation remains very worrying”.
(5) Amid all of the worry about her health, the difficult decisions around the surgery, and how to explain everything to the children, the practicalities of postponing the holiday was a relatively minor consideration.
(6) The secrecy worries me if those decisions are being made without giving us the ability to hold them to account,” says Conservative London Assembly member Andrew Boff.
(7) At the People’s Question Time in Pendle, an elderly man called Roland makes a short, powerful speech about the sacrifices made for the right to vote and says he’s worried for the future of the NHS.
(8) Wimbledon said the world No1 Williams had been suffering from a viral illness and it was a sad and bizarre end to the American’s tournament, not to mention a worrying sight, seeing her hardly able to play.
(9) The only explanation he can come up with is that Cameron is worried about his legacy.
(10) There is no doubt about it that there are authorities that have a greater need for public health money than ourselves, but Surrey still has issues and worries about certain social factors within public health," he said.
(11) Davies, who worked closely with AHTSYL's producers to ensure an accurate picture, worries that some medical stories are sold solely as "emotional journeys".
(12) "We believe BAE's earnings could stagnate until the middle of this decade," said Goldman, which was also worried that performance fees on a joint fighter programme in America had been withheld by the Pentagon, and the company still had a yawning pension deficit.
(13) The big worry here is: even if the data broker reports aggregate data, a) it has this information on an individual level – how else might it use it?
(14) It took a little bit of time to come up on the scoreboard, so I was a bit worried.
(15) Former acting director of the CIA, Michael Morell, also weighed in for Clinton in a New York Times opinion piece on Friday, declaring: “Donald J Trump is not only unqualified for the job, but he may well pose a threat to our national security.” Republicans stumbling from the wreckage of a terrible week are worrying about how to contain the damage further down the ballot paper in November as people running for seats in Congress and at state level risk being swept away.
(16) Non-worriers evidenced the same disruptive effects in the 15-worry condition as worriers in that condition and worriers in Study 1.
(17) Jenny Jones, a Green party member of the London Assembly who has campaigned to make cycling safer, said she had spoken to the deputy head of the Met's traffic unit to express her worries about the operation.
(18) What was very worrying was at half‑time when you go in the dressing room, I could sense there was no response.
(19) She said she was not worried by Rubio’s one-time position on his immigration bill, later retracted, that he could not support reform if it included citizenship for gay couples.
(20) It sells itself to British tourists as a holiday heaven of golden beaches, flamenco dresses and well-stocked sherry bars, but southern Andalucía – home to the Costa del Sol – has now become the focus of worries about the euro.