(1) These 129 studies were carried out in 108 patients, including 40 with chronic myelogenous leukemia (CML), 24 with agnogenic myeloid metaplasia (AMM), 18 with polycythemia vera (PV), six with a myelodysplastic syndrome, five with acute leukemia, three with prostate or breast carcinoma, two each with aplastic anemia or Hodgkin's disease, and one each with idiopathic thrombocythemia, multiple myeloma, chronic renal failure, or treated hypopituitarism.
(2) Serum PH activity was measured in patients with primary myelofibrosis (agnogenic myeloid metaplasia and myelofibrosis with prior history of polycythaemia vera), in patients with secondary myelofibrosis (in association with carcinoma metastasis), in patients with other myeloproliferative disorders and in controls (anaemia patients and normal volunteers).
(3) In a 75-year-old man, the rapid development of a pancytopenia as a result to total marrow failure, in the absence of tumour or extramedullary myelopoiesis, but with a histological appearance of the marrow identical to that seen in agnogenic myeloid metaplasia led to a diagnosis of malignant myelofibrosis.
(4) The complete sequences of the SV40 agnogene (LP1) and the genes coding for the capsid proteins VP1 and VP2 have been cloned into Escherichia coli expression plasmids.
(5) The effect of splenectomy on hemostatic tests was studied in 10 patients with agnogenic myeloid metaplasia.
(6) To better understand agnoprotein function and to more effectively differentiate cis-from trans-acting effects of an agnogene mutation, we constructed a mutant virus that carries a single-base-pair substitution and fails to produce agnoprotein.
(7) Of prime importance is the differentiation of CML from a leukemoid reaction or agnogenic myeloid metaplasia with a leukocytosis.
(8) This study focused only on agnogenic myeloid metaplasia (AMM).
(9) Agnogenic myeloid metaplasia (AMM) is a chronic myeloproliferative disorder that leads to a sustained proliferation of megakaryocytes and an increase of reticulin fibers within the bone marrow.
(10) We have identified trisomy 13 in two additional patients with hematologic malignancies involving the hematopoietic stem cell: a 75-year-old female with acute myelocytic leukemia and a 64-year-old female with agnogenic myelofibrosis and myeloid metaplasia.
(11) Seven years before his final hospitalization, a diagnosis of agnogenic myeloid metaplasia was made on bone marrow biopsy, and the patient was treated with phosphorus 32.
(12) A woman in the fourth year of agnogenic myeloid metaplasia was found to have partial deletion of the long arm of chromosome 20 [46,XX,del(20)(q11)] in mitoses of presumably immature myeloid cells from unstimulated cultures of peripheral blood and bone marrow.
(13) This report describes three cases of an atypical variant of agnogenic myeloid metaplasia characterized by pancytopenia, high peripheral blast cell count, lack of significant splenomegaly or tear-drop poikilocytosis, and diffuse marrow fibrosis with an abnormal proliferation of megakaryocytes.
(14) Splenic extramedullary hematopoiesis (EMH) is a characteristic finding in agnogenic myeloid metaplasia (AMM) and in the spent phase of polycythemia vera (PV).
(15) The case of an 82-year-old female patient with extramedullary haematopoiesis in the thyroid gland due to agnogenic myeloid metaplasia is reported.
(16) A 69-year-old man with agnogenic myeloid metaplasia was treated with interferon-alpha 2 as part of a Phase II clinical trial.
(17) Four patients with agnogenic myeloid metaplasia underwent liver biopsies.
(18) Analysis of two agnogene mutants, dl2304 deleted over the entire agnogene and in2379 carrying a 2-base insert, indicated that the mutant phenotype of small plaque formation must be the result of a defect late in the maturation pathway.
(19) A patient with agnogenic myeloid metaplasia suffered from gastrointestinal bleeding due to ruptured esophageal varices.
(20) The mechanisms of fibrosis remain unknown but could be attributed, by analogy to agnogenic myeloid metaplasia, to the massive destruction of platelets liberating PDGF and to increased activation of macrophages.
Idiopathic
Definition:
(a.) Alt. of Idiopathical
Example Sentences:
(1) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(3) The serum concentration of hyaluronan (HYA) was determined in 59 patients with various myeloproliferative disorders, including 33 patients with idiopathic myelofibrosis.
(4) These data indicate that CSF levels are not inversely related to the blood neutrophil count in chronic idiopathic neutropenia and suggest that CSF is not a hormone regulating the blood neutrophil count in a manner analogous to the erythropoietin regulation of circulating erythrocyte levels.
(5) In contrast, idiopathic GH deficient girls have an onset of puberty and PHV nearer to a normal chronological age and at an early bone age.
(6) Both Types I and II collagen are important constituents of the affected tissues, and thus defective collagens are reasonable candidates for the primary abnormality in adolescent idiopathic scoliosis (AIS).
(7) A new surgical procedure for idiopathic priapism has been used successfully in patients.
(8) The plasma levels of atrial natriuretic factor (ANF) were measured both during relapse and remission in 8 patients with idiopathic, minimal-lesion nephrotic syndrome.
(9) The treatment of adult patients with idiopathic scoliosis is a challenge of the 1980s.
(10) It remains to be seen, whether the small number and sterility causes were coincidental or manifest themselves in future, especially, if the sterility concerned can be classified as idiopathic.
(11) The distinction between idiopathic dilated cardiomyopathy and myocarditis is controversial, both clinically and pathologically.
(12) Complete normalization was more common in the idiopathic group (66%) than in the symptomatic group (27%).
(13) We carried out a neuropsychological study on cognitive impairment in 57 subjects affected by idiopathic Parkinson's Disease (P.D.)
(14) Thirty-three patients with idiopathic scoliotic curvatures underwent metrizamide myelography before surgery from 1979 through 1985.
(15) Two cases of idiopathic myelofibrosis of childhood were treated with intravenous methylprednisolone.
(16) In 26 patients, including the two reported here, etiology was uncertain (idiopathic aneurysm of the left ventricle) in as much as malformation or an infectious disease might have been the underlying cause.
(17) The association of idiopathic thrombocytopenic purpura (ITP) and pregnancy is of special therapeutic significance because it increases the risk to mother and infant during labor.
(18) Two patients who had had idiopathic steatorrhoea for several years developed typical eruptions of dermatitis herpetiformis.
(19) No increased incidence of pancreas divisum was found in any of four groups: an incidental group, a group with alcoholic pancreatitis, a group with unexplained upper abdominal pain, and an idiopathic pancreatitis group.
(20) This population-based case-control study of 130 Calgary residents with neurologist-confirmed idiopathic Parkinson's disease (PD) and 260 randomly selected age- and sex-matched community controls attempted to determine whether agricultural work or the occupational use of pesticide chemicals is associated with an increased risk for PD.