(a. & adv.) Past; gone by; since; as, ten years ago; gone long ago.
(1) The role of whole Mycobacteria, mycobacterial cell walls and waxes D as immunostimulants was well established many years ago.
(2) Wages for the population as a whole are £1,600 a year worse off than five years ago.
(3) Accidentally discovered nearly 40 years ago as the first true antidepressants, the MAOIs soon fell into disfavor due to concerns about toxicity and seemingly lesser efficacy compared with the newer tricyclic compounds.
(4) When my boyfriend and I first got together a year ago, our sex life was romantic and playful.
(5) Keep it in the ground campaign Though they draw on completely different archives, leaked documents, and interviews with ex-employees, they reach the same damning conclusion: Exxon knew all that there was to know about climate change decades ago, and instead of alerting the rest of us denied the science and obstructed the politics of global warming.
(6) Two years ago, the Intergovernmental Panel on Climate Change declared Egypt's Nile Delta to be among the top three areas on the planet most vulnerable to a rise in sea levels, and even the most optimistic predictions of global temperature increase will still displace millions of Egyptians from one of the most densely populated regions on earth.
(7) But the condition of edifices such as B30 and B38 - and all the other "legacy" structures built at Sellafield decades ago - suggest Britain might end up paying a heavy price for this new commitment to nuclear energy.
(8) Just a few months ago, a director-level position job for Sears was floated by me from the department store chain's headquarters in Chicago.
(9) Responding to a “We the People” petition, launched after Snowden’s initial leaks were published in the Guardian two years ago, the Obama administration on Tuesday reiterated its belief that he should face criminal charges for his actions.
(10) Emily Stow London • Until I retired a year ago I was a consultant anaesthetist with a special interest in obstetric anaesthesia and analgesia.
(11) A role for cAMP in the process of LHRH release was suggested several years ago, but only recently has the validity of this notion come under close scrutiny.
(12) Not long ago the comeback would have been impossible to imagine.
(13) Part of his initial lump sum will be donated to a fund to replace a hall destroyed by fire in an arson attack four years ago at St Luke’s Church in Newton Poppleford.
(14) In one of them, who sustained a complete membranous disruption 5 weeks ago, transluminal puncture failed because of the movable proximal urethra.
(15) New developments in data storage and retrieval forecast applications that could not have been imagined even a year or two ago.
(16) After two placings of shares with institutional investors which began two years ago, the government has been selling shares by “dribbling” them into the market.
(17) Welcomed with open arms a month ago, Syrians are now attacked on popular television talkshows where they are described as Morsi sympathisers.
(18) Two years ago I met a wonderful man and we now feel it’s time to tie the knot.
(19) Lofgren complains that " the crackpot outliers of two decades ago have become the vital centre today ".
(20) said Bengis, a Miami-based lawyer who campaigned hard for Hillary Clinton four years ago before she conceded the Democratic Party's nomination to Barack Obama.
(a. & adv.) Ago.
(n.) Agonic line.
(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.