(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Protagonist
Definition:
(n.) One who takes the leading part in a drama; hence, one who takes lead in some great scene, enterprise, conflict, or the like.
Example Sentences:
(1) The Independent noted that one of the female protagonists yelled "You c***!"
(2) There are numerous other male protagonists out there in desperate need of a sex change.
(3) At times, they gained a momentum that took even the protagonists by surprise.
(4) Phase II is the attack and destruction of the allograft by these protagonists.
(5) Not relegate them to background characters in the service of a white cis-male fictional protagonist.” Both groups have drawn their conclusions from the film’s trailer.
(6) But the bedeviled foray also works as a potent allegory on the slow, vice-like workings of conscience, as guilt hunts down the protagonists with the shrieking remorselessness of Greek furies.
(7) We don’t need a man to help us or lead us … We’re protagonists who defend a Podemos for everyone.” Iglesias responded coolly, saying he was convinced there would be “far better candidates”.
(8) Owing to the poor quality of much of this research the claims of the protagonists of these therapies cannot be proved or disproved.
(9) The roles of each protagonist are related in detail, with pragmatism.
(10) In 90 engrossing minutes came comedy, controversy, drama, breathtaking moments and an eye-catching turn from the star protagonist himself.
(11) The novelist and critic Tom Bissell has described the protagonist's Jewish lawyer in 2002's Vice City as "an anti-Semitic parody of an anti-Semitic parody", while in the new game one of the main character's daughters has a tattoo that reads "skank", and one mission involves you helping a paparazzo capture a starlet's "low-hanging muff".
(12) "But where in Dostoevsky or Poe the protagonist experiences his double as a terrifying embodiment of his own otherness (and especially his own voraciousness and destructiveness), we barely notice the difference between ourselves and our online double.
(13) Despite the world-weary tone of a brutal review in the New York Times, which suggested that it added nothing new to the "groaning shelf" of homosexual literature, a story with an unashamedly gay protagonist unleashed a storm of protest in a country where sodomy was still illegal.
(14) It was probably all over for the idea of being stoned as a portal to a higher consciousness after the release of a film in which the two perma-baked protagonists drive a car with the numberplate MUF DVR.
(15) M∆tilda – spelt with an Alt-J – references Luc Besson's film Léon and is "fuelled by the shared demise of both the protagonist and antagonist".
(16) Protagonists of the method included Ambroise Paré, Thomas Fienus, Hieronymus Fabricius ab Aquapendente, Julius Casserius, and Johannes Scultetus.
(17) Facebook Twitter Pinterest Gone Girl star Ben Affleck: ‘Usually the protagonist is full of shit’ - video interview Fincher’s film narrowly beat another new film, the horror prequel Annabelle , into second place.
(18) But the protagonists – Patty especially – are constantly making new discoveries about themselves: redemptive insights, lessons in the contradictoriness of the human heart.
(19) Writing about her novel, Wolf Hall, Hilary Mantel has explained how she brought the protagonist Thomas Cromwell alive for the reader by giving him vivid memories.
(20) Another way of assessing the claim and counterclaim is to consider the characters of the protagonists.