(v. i.) To writhe with agony; to suffer violent anguish.
(v. i.) To struggle; to wrestle; to strive desperately.
(v. t.) To cause to suffer agony; to subject to extreme pain; to torture.
Example Sentences:
(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Anguish
Definition:
(v. t.) To distress with extreme pain or grief.
(n.) Extreme pain, either of body or mind; excruciating distress.
Example Sentences:
(1) This dilemma is at the heart of many people's anguished indecision over the wisdom of our action in Iraq.
(2) British MPs are deceiving themselves if they believe they do not bear some of the responsibility for the “terrible tragedy” unfolding in Syria, the former chancellor, George Osborne, said on Tuesday during an often anguished emergency debate in the House of Commons on the carnage being inflicted in eastern Aleppo.
(3) Infertility is, in all its forms, a most private, hidden anguish.
(4) Downing street – aware of the anguish of the families of these unconfirmed Britons – has privately expressed frustration at the cumbersome process of identification of the bodies following the killings last Friday.
(5) She said: "There has been a huge amount of anguish and endless discussion of what more could have been done to save this boy.
(6) As shown in an eponymous fly-on-the-wall documentary released earlier this year, Weiner refused to bow out of the race despite the anguish of his staff and Abedin, who often looked on in silence as her husband attempted to extricate himself from the scandal.
(7) The method to overcome the resistance to dental attention due to anguish is to establish a good relation-ship between the dentist and the patient, a good management of the ambivalent feeling of the child and the elimination of the phenomenon of transference.
(8) Some gifted and canny writers have made a mint by appealing to teenagers’ sense of anguish and victimhood, the notion that they are forever embattled and persecuted by a rotten world run by authoritarian bozos.
(9) A phenomenological approach permits to confirm the intuition of language in showing that the living experience of anguish is different from the one of anxiety.
(10) The anguish families experience when they are asked to make health care decisions for incompetent members has stimulated the search for adequate prior directives.
(11) It is a bizarre, fascinating, crazily over-the-top piece of self-portraiture which verges on self-vivisection, culminating in Kim's cracked performance of "Arirang", a Korean folk-song replete with anguish.
(12) This man’s anguish and his love for his children pour out of your image and it is [a] look that I saw in the faces of countless people as we took them from the boats.” Working on deadline, I lost track of the family.
(13) He spoke out after a survey of 23,000 women's views of their birth experience with the NHS revealed significant dissatisfaction, and sometimes anger and anguish.
(14) In my experience as a GP, I have learned that many people feel embarrassed and ashamed in telling a doctor about their mental anguish.
(15) EPA Gazza’s Italia 90 tears were but a trickling tributary compared with the Amazon of anguish unleashed by the shell-shocked hosts during their mortifying 7-1 loss to Germany.
(16) But Brief Encounter has survived such threats, because it is so well made, because Laura's voiceover narration is truly anguished and dreamy, because the music suckers all of us, and because Celia Johnson and Trevor Howard are perfect.
(17) Admission to a critical care unit often causes a great deal of distress and anguish, not only for the patient but also his or her family.
(18) It was hinted at this week by Adam Posen , retiring member of the Bank's monetary policy committee, in criticising his colleagues for their "anguished religious ethics" over quantitative easing.
(19) Yet the Brazilians who were photographed unleashing their sorrow on a cloudy, darkening evening, in scenes of anguish from Estádio Mineirão to Copacabana beach, were not mourning a massacre, atrocity or anything else that might seem to justify such infinite sadness.
(20) "I know these measures are very tough … I am acutely aware of the hardship and the anguish such sacrifices have caused for Greeks," said Venizelos, adding that the measures would save the state €6.5bn – the equivalent of 3% of GDP.