(v. i.) To writhe with agony; to suffer violent anguish.
(v. i.) To struggle; to wrestle; to strive desperately.
(v. t.) To cause to suffer agony; to subject to extreme pain; to torture.
Example Sentences:
(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Desperately
Definition:
(adv.) In a desperate manner; without regard to danger or safety; recklessly; extremely; as, the troops fought desperately.
Example Sentences:
(1) Michael Schumacher’s manager hopes F1 champion ‘will be here again one day’ Read more Last year, Red Bull were frustrated by Mercedes, Ferrari and Honda as they desperately looked for a new engine supplier.
(2) It is my desperate hope that we close out of town.” In the book, God publishes his own 'It Getteth Better' video and clarifies his original writings on homosexuality: I remember dictating these lines to Moses; and afterward looking up to find him staring at me in wide-eyed astonishment, and saying, "Thou do knowest that when the Israelites read this, they're going to lose their fucking shit, right?"
(3) While they may always be encumbered by censorship in a way that HBO is not, the success of darker storylines, antiheroes and the occasional snow zombie will not be lost in an entertainment industry desperate to maintain its share of the audience.
(4) Many hope this week's photocalls with the two men will be a recruiting aid and provide a desperately needed bounce in the polls.
(5) Hamilton said it was uncanny to find themselves in another desperate emergency situation almost exactly one year on.
(6) There are numerous other male protagonists out there in desperate need of a sex change.
(7) Frederick Juuko, a Ugandan law professor and critic of foreign influence in Ugandan politics, agrees that homosexuality is a pawn for many in times of desperation, including government.
(8) 9.23pm GMT Expect the reporters to get even more speculative and desperate from hereon in.
(9) He said: “Almost daily we hear from parents desperate to escape the single cramped room of a B&B or hostel that they find themselves struggling to raise their children in.
(10) The report's authors warns that to limit their spending councils will have "an incentive to discourage low-income families from living in the area" and that raises the possibility that councils will – like the ill-fated poll tax of the early 1990s – be left to chase desperately poor people through the courts for small amounts of unpaid tax.
(11) The local MP, Rory Stewart, a mover and shaker on the broadband project, told me that he was desperate to get telehealth into Cumbria, but regretfully felt that it was not immediately doable, because the local council and healthcare community did not yet have the necessary expertise.
(12) In desperation, I cancelled my contract with Sky and placed a new order with BT in February.
(13) When I heard it, I thought of Sherpa as a first name, like the Edmund in Edmund Hillary, rather than as a description, like the Desperate in Desperate Dan.
(14) Clark said he first met Brown in November 2004, just a few months before the general election when the party was in desperate need of funds.
(15) I tried desperately hard not to influence her, but I did steer her away from a baby that I've already bought her for her Christmas present.
(16) Patel once wrote: “At one end of this world, there is one woman who desperately needs a baby and cannot have her own child.
(17) Families like these are being abandoned to their fate and, as Steve Hynes of the Legal Action Group says: "These are often truly desperate people."
(18) Michael Holroyd, in his biography of George Bernard Shaw , gives an illuminating example of myopic hostility to Russia by the right even when we desperately needed allies.
(19) Police reinforcements are being sent to the embattled port of Calais in an attempt to prevent increasingly desperate attempts by migrants to gain access to the UK.
(20) "I desperately don't want this to suppress people's choice and freedom," says Stansfield.