(v. i.) To writhe with agony; to suffer violent anguish.
(v. i.) To struggle; to wrestle; to strive desperately.
(v. t.) To cause to suffer agony; to subject to extreme pain; to torture.
Example Sentences:
(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Worry
Definition:
(v. t.) To harass by pursuit and barking; to attack repeatedly; also, to tear or mangle with the teeth.
(v. t.) To harass or beset with importunity, or with care an anxiety; to vex; to annoy; to torment; to tease; to fret; to trouble; to plague.
(v. t.) To harass with labor; to fatigue.
(v. i.) To feel or express undue care and anxiety; to manifest disquietude or pain; to be fretful; to chafe; as, the child worries; the horse worries.
(n.) A state of undue solicitude; a state of disturbance from care and anxiety; vexation; anxiety; fret; as, to be in a worry.
Example Sentences:
(1) But the position of locum GPs remains worryingly unsure.
(2) I know I have the courage to deal with all the sniping but you worry about the effects on your family."
(3) If Lagarde had been placed under formal investigation in the Tapie case, it would have risked weakening her position and further embarrassing both the IMF and France by heaping more judicial worries on a key figure on the international stage.
(4) In Paris, a foreign ministry spokesman, Romain Nadal, said the French authorities were “fully mobilised to help Serge Atlaoui, whose situation remains very worrying”.
(5) Amid all of the worry about her health, the difficult decisions around the surgery, and how to explain everything to the children, the practicalities of postponing the holiday was a relatively minor consideration.
(6) The secrecy worries me if those decisions are being made without giving us the ability to hold them to account,” says Conservative London Assembly member Andrew Boff.
(7) At the People’s Question Time in Pendle, an elderly man called Roland makes a short, powerful speech about the sacrifices made for the right to vote and says he’s worried for the future of the NHS.
(8) Wimbledon said the world No1 Williams had been suffering from a viral illness and it was a sad and bizarre end to the American’s tournament, not to mention a worrying sight, seeing her hardly able to play.
(9) The only explanation he can come up with is that Cameron is worried about his legacy.
(10) There is no doubt about it that there are authorities that have a greater need for public health money than ourselves, but Surrey still has issues and worries about certain social factors within public health," he said.
(11) Davies, who worked closely with AHTSYL's producers to ensure an accurate picture, worries that some medical stories are sold solely as "emotional journeys".
(12) "We believe BAE's earnings could stagnate until the middle of this decade," said Goldman, which was also worried that performance fees on a joint fighter programme in America had been withheld by the Pentagon, and the company still had a yawning pension deficit.
(13) The big worry here is: even if the data broker reports aggregate data, a) it has this information on an individual level – how else might it use it?
(14) It took a little bit of time to come up on the scoreboard, so I was a bit worried.
(15) Former acting director of the CIA, Michael Morell, also weighed in for Clinton in a New York Times opinion piece on Friday, declaring: “Donald J Trump is not only unqualified for the job, but he may well pose a threat to our national security.” Republicans stumbling from the wreckage of a terrible week are worrying about how to contain the damage further down the ballot paper in November as people running for seats in Congress and at state level risk being swept away.
(16) Non-worriers evidenced the same disruptive effects in the 15-worry condition as worriers in that condition and worriers in Study 1.
(17) Jenny Jones, a Green party member of the London Assembly who has campaigned to make cycling safer, said she had spoken to the deputy head of the Met's traffic unit to express her worries about the operation.
(18) What was very worrying was at half‑time when you go in the dressing room, I could sense there was no response.
(19) She said she was not worried by Rubio’s one-time position on his immigration bill, later retracted, that he could not support reform if it included citizenship for gay couples.
(20) It sells itself to British tourists as a holiday heaven of golden beaches, flamenco dresses and well-stocked sherry bars, but southern Andalucía – home to the Costa del Sol – has now become the focus of worries about the euro.