(v. i.) To writhe with agony; to suffer violent anguish.
(v. i.) To struggle; to wrestle; to strive desperately.
(v. t.) To cause to suffer agony; to subject to extreme pain; to torture.
Example Sentences:
(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Wrestle
Definition:
(v. t.) To contend, by grappling with, and striving to trip or throw down, an opponent; as, they wrestled skillfully.
(v. t.) Hence, to struggle; to strive earnestly; to contend.
(v. t.) To wrestle with; to seek to throw down as in wrestling.
(n.) A struggle between two persons to see which will throw the other down; a bout at wrestling; a wrestling match; a struggle.
Example Sentences:
(1) This week they are wrestling with the difficult issue of how prisoners can order clothes for themselves now that clothing companies are discontinuing their printed catalogues and moving online.
(2) Perhaps it’s the lot of people like my colleagues here in the centre and me to wrestle with our consciences, shed tears, lose sleep and try to make the best of a very bad, heart-breaking job and leave the rest of the world to party, get pissed and celebrate Christmas.
(3) Can the protests, which tried, ultimately without success, to wrestle genuine universal suffrage from Beijing, be called a failure?
(4) However, the shadow foreign secretary, Douglas Alexander , is adamant Labour could not afford to spend the first two years of government wrestling with a referendum on Europe, pointing to the energy it had expended on the near-disastrous no campaign for the Scotland independence vote.
(5) Anthropometric characteristics, passive hip flexion, and spinal mobility were examined and back pain was registered in 116 top Swedish male athletes representing four different sports (wrestling, gymnastics, soccer, tennis).
(6) But the Lib Dems' conference, which starts on Saturday in Glasgow, may be marked by a series of internal disputes as the leadership and party activists wrestle over strategy, policies and the independence of its manifesto.
(7) Celebrity Wrestling is the biggest failure of the ITV 2005 schedule so far.
(8) Heselden's only reservation about the ceremony, said David Robinson, would have been the time it took 30 or more staff to wrestle with erecting the marquee.
(9) This failure to wrestle with what’s coming goes wider.
(10) Updated at 6.57pm BST 6.49pm BST A congressman, Rep. Dana Rohrabacher (R-CA), once lost an arm-wrestling match against Russian president Vladimir Putin , and now he has told the world about it.
(11) Instead he realised that while his teammates were wrestling him on the ground in celebration, he hadn’t yet shaken hands with his opponent, David Goffin.
(12) – are all questions that many health and care economies around the country are still wrestling with.
(13) But Bony knows he has the trust of me and the team.” A second Ivorian joined him among the goals when Damien Delaney wrestled Eliaquim Mangala to the ground and Touré scored from the resulting penalty.
(14) Hookem said: “It was two people grappling, that had hold of each other, and were basically still stood up but wrestling.
(15) He had wrestled one of the gunmen – there were marks on his arms where he had attempted to fight them off – and been shot in the chest, dying instantly.
(16) A wrestler's weight is often determined by the need to fill a wrestling class and not on a good scientific basis.
(17) It is by no means a total success artistically but it has enough tension, feeling and originality of theme and speech to make the choice understandable, and the evening must have given to anyone who has wrestled with the mechanics of play-making an uneasy and yet not wasted jaunt, just as it must have awoken echoes in anyone one who has not forgotten the frustrations of youth.
(18) There are a number of common problems that affect the whole of our media spectrum, all of which have at some point to be wrestled to the ground if we're to ever move beyond what I see as this potentially self-destructive phase in our historical development.
(19) The room held 52' Carl Hutchinson My childhood hero was World Wrestling Entertainment's Mick Foley .
(20) So it is with Ukip: this party has made no rational sense since it captured the name from its anti-federalist founders and wrestled it into a one-man, anti-everything machine.