(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Excruciating
Definition:
(p. pr. & vb. n.) of Excruciate
() Torturing; racking.
Example Sentences:
(1) A 33-year old woman was admitted with high fever and excruciating pain in the lower right abdomen that had lasted on and off for months.
(2) However, after her diagnosis, it became my occupation to know everything about her ailment because I was her caregiver during her excruciating decline.
(3) It is an excruciating fly-on-the-wall witness to Allison's vainglory, Swales's self-regard for his own leadership qualities and the poor young players' overpromoted helplessness.
(4) Another great feature of the panda, at least as far as Chairman Mao Zedong and his followers were concerned, was that the rest of the world, particularly the west, had become obsessed by its excruciatingly cute looks and behaviour.
(5) Far from being relaxed, I feel excruciatingly uncomfortable and begin to wonder if my jaw is malfunctioning.
(6) (Mail Online goes into excruciating detail on the methods Williams used, but does so in the body copy of an article.)
(7) The film charts in excruciating detail the collapse of a political career and, ultimately, of a marriage.
(8) One more win now, one more good performance against the sort of team they have swatted aside all season, and the long, often excruciating wait will be over: City will be champions.
(9) In the very act of describing sex as an incidental, you create an excruciating sex scene.
(10) Our most excruciating agony is of not being noticed in the world.
(11) An effective piece of propaganda at the time, it makes pretty excruciating viewing now that we know what happens next.
(12) With Foord having lost his entire leg, including his hip, even getting him out of bed and sitting in his wheelchair was excruciating.
(13) "The timing is excruciating for whomever wins the next election."
(14) A women who has been infibulated suffers great difficulty and pain during sexual intercourse, which can be excruciating if a neuroma has formed at the point of section of the dorsal nerve of the clitoris.
(15) During the first postoperative week little pain was experienced by 60% of the patients, considerable pain by 35% and excruciating pain by 5% of the patients being interviewed.
(16) Yet if I tell you I’ve had a chronic illness since early childhood that is known for excruciating pain, for causing immobility and secondary – sometimes life-threatening – conditions, does that change your view of my suicide attempt?
(17) As well as being a pallid substitute for actual creativity – a device for making grey business wonks mistake themselves for David Bowie at his experimental peak – these books are the direct suit-and-tie office-dick equivalent of those embarrassing motivational self-help tomes that prey on the insecure, promising to turn their life around before dissolving into a blancmange of "strategies" and "systems" and above all excruciating metaphors.
(18) Perhaps it signifies an end to those media appearances in which politicians share the contents of their iPods or talk, excruciatingly, about their love of whatever indie band their aide has decided they should like, in an attempt to persuade voters they're young and fun.
(19) The real importance of Thomas Piketty's blockbuster, Capital in the 21st Century , is that it demonstrates, in excruciating detail (and this remains true despite some predictable petty squabbling) that, in the case of at least one core equation, the numbers simply don't add up .
(20) The disease is often serious and can cause excruciating pain in the joints and other parts of the body.