What's the difference between agrin and happiness?
Agrin
Definition:
(adv. & a.) In the act of grinning.
Example Sentences:
(1) These results provide the first demonstration that embryonic neurons supply agrin-like molecules to the synapses they form with embryonic muscle cells.
(2) The stimulation of the expression of agrin-related molecules in these long-term cultures requires the presence of chick embryo extract or fetal calf serum.
(3) Agrin, a protein isolated from the synapse-rich electric organ of Torpedo californica, induces the formation of specializations on myotubes in culture which resemble the post-synaptic apparatus at the vertebrate skeletal neuromuscular junction.
(4) Agrin enriched by immunoaffinity chromatography from the central nervous system induced large numbers of AChR aggregates on cultured myotubes.
(5) We conclude that agrin released by rat motor neurons induced the chick myotubes to aggregate AChRs.
(6) Agrin-induced formation of AChR aggregates was not prevented by inhibition of protein synthesis, consistent with our previous results that agrin-induced accumulation of AChRs occurs by lateral migration.
(7) The rat agrin protein is concentrated at synapses, where it may play a role in development and regeneration.
(8) Immunofluorescence shows that on myotubes incubated with agrin at 4 degrees C, agrin binds in a uniform, finely punctate pattern that correlates poorly with the distribution of AChRs.
(9) By contrast, actin (visualized with fluorescein-phalloidin) and tropomyosin did not show specific associations with agrin-induced AChR clusters.
(10) In the present study we examined the role of extracellular matrix components in agrin-induced differentiation.
(11) Myotubes stimulated with agrin at 37 degrees C for greater than or equal to 2 hr show a coclustering of agrin binding sites and AChRs.
(12) The accumulation of AChE and BuChE into agrin-induced aggregates occurred in the absence of any change in the amount, rate of synthesis, accumulation, and release, or molecular forms of either enzyme.
(13) We also characterized the expression of muscle-derived agrin-like molecules at clusters of AChR.
(14) Here I report that the major agrin-like proteins from the nervous system and other tissues of the chicken are immunochemically and biochemically similar.
(15) Thus, in developing muscle, agrin or a closely related molecule (a) is expressed before AchR clusters are detected; (b) is colocalized with the earliest AchR clusters formed; and (c) can be expressed in muscle and at sites of high AchR density independently of innervation.
(16) These results demonstrate that expression of a single gene encoding agrin confers receptor clustering that is restricted to specific sites of cell-muscle contact.
(17) Other lines of study have provided clues as to how nerve-derived (extracellular) AChR-cluster inducing factors such as agrin might activate 43k-driven postsynaptic membrane specialization.
(18) However, as dorsal and ventral premuscle masses condensed (stage 22-23), mesenchymal immunoreactivity for laminin and agrin-like proteins, but not the proteoglycan, became concentrated in these myogenic regions.
(19) Immunofluorescent staining with an anti-agrin antibody reactive at Rana but not at Xenopus neuromuscular junctions was positive only at cross-species nerve-muscle contacts involving Rana neurons.
(20) Here we present evidence that agrin is highly concentrated in the cell bodies of motor neurons and is transported to axon terminals which is consistent with the agrin hypothesis.
Happiness
Definition:
(n.) Good luck; good fortune; prosperity.
(n.) An agreeable feeling or condition of the soul arising from good fortune or propitious happening of any kind; the possession of those circumstances or that state of being which is attended enjoyment; the state of being happy; contentment; joyful satisfaction; felicity; blessedness.
(n.) Fortuitous elegance; unstudied grace; -- used especially of language.
Example Sentences:
(1) This is not an argument for the status quo: teaching must be given greater priority within HE, but the flipside has to be an understanding on the part of students, ministers, officials, the public and the media that academics (just like politicians) cannot make everyone happy all of the time.
(2) Infants were habituated to models posing either prototypically positive displays (e.g., happy expressions) or positive expression blends (e.g., mock surprise).
(3) His greatest legacy, besides his three children, is the joy and happiness he offered to others, particularly to those fighting personal battles.
(4) United and West Ham are on similar runs and can feel pretty happy about themselves but are not as confident away from home as they are at home and that will have to change if they are to make ground on the top teams.
(5) Not even housebuilders are entirely happy, although recent government policies such as Help to Buy and the encouragement of easy credit have helped their share prices rise.
(6) I’m so happy to be joining Arsenal, a club which has a great manager, a fantastic squad of players, huge support around the world and a great stadium in London,” said Sánchez.
(7) As for gay men, there is absolutely nothing that suggests they are any less war-happy than heterosexuals.
(8) While the Spielberg of popular myth is Mr Nice Guy, Lean was known as an obsessive, cantankerous tyrant who didn't much like actors and was only truly happy locked away in the editing suite.
(9) That latter issue is quite controversial in Germany, where the Bundesbank is not happy about surrendering control to the ECB .
(10) The first problem facing Calderdale is sheep-rustling Happy Valley – filmed around Hebden Bridge, with its beautiful stone houses straight off the pages of the Guardian’s Lets Move To – may be filled with rolling hills and verdant pastures, but the reality of rural issues are harsh.
(11) Outwardly, his life was successful, happy, on course.
(12) Pointing out that “the army has its own fortune teller”, he sounds less than happy at the state of affairs: “The country is run by superstition.” Weerasethakul is in a relatively fortunate position, in that his arcane films are not exactly populist and don’t depend on the mainstream Thai film industry for funding, but he has become cast as a significant voice of dissent in a difficult time .
(13) John Hansen, president of the Nebraska Farmers Union, said the landowners his group represents "are obviously not happy" that the beetles are being removed.
(14) I was just happy he got his licence back so I could clean him out."
(15) He is an academy product and truthfully we are, and me above all, happy to have him with us.
(16) Thirty-two nursing students were shown silent films in which 10 normal and 10 schizophrenic women described a happy, sad, and an angry personal experience.
(17) Indeed, the distribution of couples according to a multifactorial risk index does in fact establish a connection between the couple's happiness and the level of risk during sexual relations within and outside the couple.
(18) But some wise old heads sniff into their handkerchiefs because they have sat through too many costly "happy ever after" ceremonies that ended in acrimony.
(19) I can calmly say that his future will still be at Juventus, where he feels very happy,” he parped.
(20) In a series of analyses guided by intuitive hypotheses, the Smith and Ellsworth theoretical approach, and a relatively unconstrained, open-ended exploration of the data, the situations were found to vary with respect to the emotions of pride, jealousy or envy, pride in the other, boredom, and happiness.