(n.) An organic base belonging to the phenylamines. It may be regarded as ammonia in which one hydrogen atom has been replaced by the radical phenyl. It is a colorless, oily liquid, originally obtained from indigo by distillation, but now largely manufactured from coal tar or nitrobenzene as a base from which many brilliant dyes are made.
(a.) Made from, or of the nature of, aniline.
Example Sentences:
(1) Pretreatment of rats with 6-(3-picolyl)amino-2,2,5,8-tetramethylchromane (PATC) for 7 days resulted in a significant increase in the activities of benzphetamine N-demethylase, p-nitroanisole O-demethylase and aniline hydroxylase in liver microsomes prepared 24 h after the last treatment.
(2) Comparison of the specific activities for aniline hydroxylation and p-nitrophenol hydroxylation of individual microsomal samples from control, ethanol-pretreated and phenobarbital-pretreated animals showed a high degree of correlation (r2 = 0.98) consistent with the involvement of the same site for catalysis of these two compounds.
(3) Chlordimeform had no effect on the cytochrome P-450 content, aniline p-hydroxylase or glutathione S-transferase activities, but induced ethoxyresorufin-O-deethylase, ethoxycoumarin-O-deethylase and epoxide hydrolase activities and decreased aldrin epoxidase and aminopyrine N-demethylase activities.
(4) Intestinal aniline hydroxylation was refractory to ethanol induction.
(5) Incubation of aniline-metabolizing hepatocytes with disulfiram resulted in decreased formation of 4-aminophenol, but this was not associated with impaired glucuronidation or cytochrome P-450 levels.
(6) At 20 degrees C, in a phosphate buffer, pH 5,8--8,0, methanol and aniline interactions with hemoglobin and cytochrome c were studied using the difference spectrophotometry method.
(7) Activities of amidopyrine N-demethylase, aniline hydroxylase, NADPH, cytochrome c reductase as well as content of cytochromes P-450 and b5 were studied in liver tissue of rats within 1, 3, 7, 10, 20 and 30 days of hypokinesia caused by maintaining of the animals in individual cell-cases.
(8) In contrast, menadione does not change the type II binding spectrum induced by aniline.
(9) Enzymatic polymerization took place on the surface of BOD-adsorbed solid matrix which was in contact with a buffer solution containing aniline.
(10) In NADPH-containing microsomal systems with 4-fluoro-substituted anilines, formation of the 4-hydroxyaniline derivative is observed because NADPH chemically reduces this quinoneimine metabolite.
(11) The activity of aniline hydroxylase was significantly increased in liver microsomes of EHBR whereas the activity of ethylmorphine N-demethylase was found to be significantly decreased in EHBR as compared to control rats.
(12) When compared to the first day, methemoglobin (MetHb) levels, measured prior to and following the exposure, increased with the days of exposure at 50 ppm aniline.
(13) Although metabolic attack occurred adjacent to either the aniline nitrogen or the aliphatic amine, metabolic attack occurred primarily adjacent to the more basic nitrogen at the 1'-position, even when this position bore a methyl substituent.
(14) Carbon monoxide inhibits the hydroxylase activity of the tissue-free system to a smaller extent than that of a system containing microsomes plus haemoglobin whereas p-chloromercuribenzoate inhibits only the flavoprotein-dependent hydroxylation of aniline mediated by haemoglobin.
(15) The profiles of urinary metabolites produced by rats and mice were not appreciably different in animals predosed with aniline.
(16) The results indicate that aniline degrading populations of these various microbial communities exhibit different activities probably depending on the extent of adaptation to pollutants to which the microbes are exposed.
(17) A high-pressure liquid chromatographic method has been developed for the determination of nanomole quantities of aniline; its metabolites o- and p-aminophenol, phenylhydroxylamine, nitrosobenzene and nitrobenzene; and azobenzene and azoxybenzene which form non-enzymatically by condensation of reactive metabolites.
(18) A series of ortho-quinone analogues 1-28 of podophyllotoxin possessing various C-4 beta-aniline moieties have been synthesized and evaluated for their inhibitory activity against human DNA topoisomerase II, their activity in causing cellular protein-linked DNA breakage, and their cytotoxicity against KB cells.
(19) The inhibitory effect of the nitroso-compound is demonstrated to be non-competitive on aminopyrine N-demethylase, p-nitroanisole O-demethylase and aniline hydroxylase.
(20) Compared with the control values, the levamisole treatment significantly increased the amount of cytochrome P450 and cytochrome b5 and the in-vitro activities of aminopyrine N-demethylase, benzphetamine N-demethylase and aniline hydroxylase.
Basic
Definition:
(a.) Relating to a base; performing the office of a base in a salt.
(a.) Having the base in excess, or the amount of the base atomically greater than that of the acid, or exceeding in proportion that of the related neutral salt.
(a.) Apparently alkaline, as certain normal salts which exhibit alkaline reactions with test paper.
(a.) Said of crystalline rocks which contain a relatively low percentage of silica, as basalt.
Example Sentences:
(1) F(420) is photolabile aerobically in neutral and basic solutions, whereas the acid-stable chromophore is not photolabile under these conditions.
(2) Despite of the increasing diagnostic importance of the direct determination of the parathormone which is at first available only in special institutions in these cases methodical problems play a less important part than the still not infrequent appearing misunderstanding of the adequate basic disease.
(3) Anytime they feel parts of the Basic Law are not up to their current standards of political correctness, they will change it and tell Hong Kong courts to obey.
(4) Helsby, who joined the estate agent in 1980, saw his basic salary unchanged at £225,000, but gains a £610,000 windfall in shares, available from May, as well as a £363,000 increase in cash and shares under the company profits-sharing scheme.
(5) Employed method of observation gave quantitative information about the influence of odours on ratios of basic predeterminate activities, insect distribution pattern and their tendency to choose zones with an odour.
(6) These four cytokeratins were also found in the epithelial and biphasic mesotheliomas, most of which, however, also expressed, additional cytokeratins, such as the basic Polypeptide 5 and, in some cases, Cytokeratins 4, 6, 14, and 17.
(7) The deactivated columns had the residual silanols on the silica gel chemically inactivated to reduce the interaction with basic groups or analytes.
(8) Attachment of the graft to the wound is similar with and without the addition of human basic fibroblast growth factor, a potent angiogenic agent, to the skin replacement before graft placement on wounds.
(9) This is basically a large tank (the bigger the better) that collects rain from the house guttering and pumps it into the home, to be used for flushing the loo.
(10) The determination of basic levels of TSH is more sensitive and more precise.
(11) The authors present the first results on the utilization of fish infusion (IFP) as a basic medium for the cultivation of bacteria.
(12) The mother in Arthur Ransome's children's classic, Swallows and Amazons, is something of a cipher, but her inability to make basic decisions does mean she receives one of the finest telegrams in all literature.
(13) We set a new basic plane on an orthopantomogram in order to measure the gonial angle and obtained the following: 1) Usable error difference in ordinary clinical setting ranged from 0.5 degrees-1.0 degree.
(14) All 3 drugs increased the basic cycle length of pacing at which VT was induced and the cycle time of the resulting VT.
(15) The problem-based system provides a unique integration of acquiring theoretical knowledge in the basic sciences through clinical problem solving which was highly rated in all analysed phases.
(16) We measured CSF immunoreactive myelin basic protein (MBP), a marker of acute myelin damage, and sIL-2R levels in the CSF from 11 patients with active relapsing remitting (RR) MS, five with stable RR MS, eight with chronic progressive (CP) MS, five with other neurologic diseases, and three normal controls.
(17) One of the proteases obtained was found to catalyse cleavage on the COOH-side of peptide sequences containing consecutive hydrophobic and basic residues.
(18) TCR beta chain gene expression of individual T cell clones that share the same MHC class II restriction and similar fine specificity for the encephalitogenic NH2 terminus of the autoantigen myelin basic protein (MBP) has been examined.
(19) Basic components of and differences between various forms of contrast treatment are discussed.
(20) Basic problem areas in the design and conduct of this assay in humans will also be discussed, as will the future potential of the assay.