(n.) The Altar; a southern constellation, south of the tail of the Scorpion.
(n.) A name of the great blue and yellow macaw (Ara ararauna), native of South America.
Example Sentences:
(1) The antitumor effect of C18PCA and Ara-C was investigated against the P388 ascites tumor in BDF1 mice.
(2) However, the walker 256 intramuscular tumor did not respond to ARA-C capsules implanted, and the animals died at the same rate as the controls, with large ulcerated tumor masses and some metastasis.
(3) 5 heavily pretreated patients with chronic lymphocytic leukaemia or non-Hodgkin lymphoma resistant to alkylating agents were treated with low-dose cytosine arabinoside (ARA-C).
(4) Rat liver microsomes demethylated ara-DMAP much more rapidly than human liver microsomes did.
(5) Enhanced ara-CTP formation was observed in cells lacking cytidine deaminase (L1 210 and HL60), indicating that 3-deazauridine inhibition of deoxycytidylate deaminase may be important in this drug interaction.
(6) This study demonstrates the mutagenic properties of F-ara-A and ara-A and provides evidence for mechanisms by which the arabinosyl nucleosides induce mutation.
(7) Patient cells had low rates for ara-C transport as compared with human and murine experimental cells and correspondingly low binding capacities for the nucleoside transport inhibitor, nitrobenzylmercaptopurine riboside (NBMPR).
(8) The inhibitions by ara-GTP and 9-beta-D-arabinofuranosyladenine 5'-triphosphate were due to competition or partial competition 5'-triphosphate were due to competition or partial competition with deoxynucleoside triphosphate with the same base.
(9) The incorporation of F-ara-A monophosphate into mRNA resulted in premature termination of the RNA transcript and impaired its functioning as a template for protein synthesis.
(10) Pharmacological studies of 5'-esters of 1 beta-D-arabinofuranosylcytosine (ara-C) were performed in three species (mouse, pig, and man).
(11) These results provide some support for the view that cell kill may not be the only basis for the chemotherapeutic effectiveness of ara-C.
(12) Accelerating test at a constant temperature indicates that liposome-entrapped Ara-A has certain chemical stability.
(13) Although statistically significant, the effect of DP on ara-CTP retention in AML blasts was much less pronounced than that previously observed in L5178Y leukemia.
(14) He was treated with the combination chemotherapy of BACOD with high dose ara-C or methotrexate followed by 4 doses of autologous LAK cell infusion resulting in no significant response.
(15) Regardless whether cyclo-C or ara-C is injected, the plasma decay curve of the resultant ara-C is biphasic, with calculated half-lives of 40 min and 2-2.5 hr.
(16) Serial measurements of DNA synthesis and net intracellular ara-C metabolism demonstrated marked increases in both determinants in day 8 residual tumor when compared with the pretreatment cells for newly diagnosed adults achieving complete remission but not for TST-refractory patients.
(17) Determination of the intracellular content of the active metabolite of ara-C, ara-CTP, excluded more prolonged retention of the drug as the basis for potentiation of cytotoxicity.
(18) With the aim of improving the treatment of AML patients the activities of selected nucleoside metabolizing enzymes of possible implication for the initial metabolism of Ara-C have been studied in leukemic and normal cells.
(19) Ara-C. We conclude that prophylactic CNS therapy may cause cognitive dysfunctions.
(20) This was possible because the Ara test, for volatile compounds (such as vinyl bromide), did not require the use of special vaporization techniques, which are difficult to evaluate quantitatively for mutagenic activity.
Ark
Definition:
(n.) A chest, or coffer.
(n.) The oblong chest of acacia wood, overlaid with gold, which supported the mercy seat with its golden cherubs, and occupied the most sacred place in the sanctuary. In it Moses placed the two tables of stone containing the ten commandments. Called also the Ark of the Covenant.
(n.) The large, chestlike vessel in which Noah and his family were preserved during the Deluge. Gen. vi. Hence: Any place of refuge.
(n.) A large flatboat used on Western American rivers to transport produce to market.
Example Sentences:
(1) From the moment God speaks to him until he leaves the ark and steps on to dry land, he never says a word.
(2) Specific-pathogen-free leghorn sentinel chickens were vaccinated with Massachusetts (Mass) alone, Mass and JMK, or Mass and Arkansas (Ark) combination live vaccines, or they remained unvaccinated.
(3) The manifesto sets out how every hospital can be given the autonomy of a foundation hospital and 1,000 coasting or failing schools could join federations, including state school chains or non-state providers such as Ark.
(4) As with beta ARK, phosphorylation of the receptor substrates by beta ARK2 was completely stimulus dependent.
(5) Relying on Hitler for an analogy makes people sound as if their history lessons were limited to Indiana Jones And The Raiders Of The Lost Ark.
(6) The beta-adrenergic receptor kinase (beta ARK) mediates agonist-dependent phosphorylation of the beta 2-adrenergic and related G protein-coupled receptors.
(7) Using chimaeric beta ARKs that undergo isoprenylation in vitro, we demonstrate that membrane association and activation of these kinases can occur in the absence of beta gamma.
(8) Purified hamster beta 2AR was phosphorylated by cAMP-dependent protein kinase (PKA), protein kinase C (PKC), or beta AR kinase (beta ARK), and receptor function was determined by measuring the beta 2AR-agonist-promoted Gs-associated GTPase activity.
(9) Although maximal stimulation of beta-subunit phosphorylation was reduced to 30% in proband Ark-1 fibroblasts, this reduction was quantitatively related to reduced insulin binding.
(10) He could flog his fish to the secondhand shop, or maybe sell them on the street, the way his neighbour does stolen trainers, maybe diversifying into Noah’s Arks.
(11) Sir Mark Stanhope, the head of the navy, told the committee that the aircraft carrier Ark Royal and its jumpjet Harriers would have been used to bomb Libya had they not been axed.
(12) Not present at their own trial, or to bear witness to all the controversy generated by their actions, are two key figures in Zoe's Ark: chairman Éric Breteau and his partner Émilie Lelouche.
(13) But my grandfather saw it as the citadel, the Ark; it preserved history, which was his mission.
(14) He receives his orders to build the ark and sets about it.
(15) The Ark by Ralph Erskine, next to the Hammersmith flyover in London, is a large steel-and-glass building, an insect with its wings cut off.
(16) With Ark in place, offering staff better terms of pay and stability that comes with a track record of steering outstanding and good schools, the best teachers were willing to join Conway primary school's little revolution.
(17) This protein tyrosine kinase called ark (adhesion-related kinase) is likely to represent a new class of receptor tyrosine kinase.
(18) The sequence was very similar to that of the bovine beta ARK (the overall amino acid homology was 98%).
(19) G protein beta gamma subunits were shown to interact directly with the COOH-terminal region of beta ARK, and formation of this beta ARK-beta gamma complex resulted in receptor-facilitated membrane localization of the enzyme.
(20) The beta-adrenergic receptor kinase (beta-ARK), which specifically phosphorylates only the agonist-occupied form of the beta-adrenergic and closely related receptors, appears to be important in mediating rapid agonist-specific (homologous) desensitization.