(n.) The oblong chest of acacia wood, overlaid with gold, which supported the mercy seat with its golden cherubs, and occupied the most sacred place in the sanctuary. In it Moses placed the two tables of stone containing the ten commandments. Called also the Ark of the Covenant.
(n.) The large, chestlike vessel in which Noah and his family were preserved during the Deluge. Gen. vi. Hence: Any place of refuge.
(n.) A large flatboat used on Western American rivers to transport produce to market.
Example Sentences:
(1) From the moment God speaks to him until he leaves the ark and steps on to dry land, he never says a word.
(2) Specific-pathogen-free leghorn sentinel chickens were vaccinated with Massachusetts (Mass) alone, Mass and JMK, or Mass and Arkansas (Ark) combination live vaccines, or they remained unvaccinated.
(3) The manifesto sets out how every hospital can be given the autonomy of a foundation hospital and 1,000 coasting or failing schools could join federations, including state school chains or non-state providers such as Ark.
(4) As with beta ARK, phosphorylation of the receptor substrates by beta ARK2 was completely stimulus dependent.
(5) Relying on Hitler for an analogy makes people sound as if their history lessons were limited to Indiana Jones And The Raiders Of The Lost Ark.
(6) The beta-adrenergic receptor kinase (beta ARK) mediates agonist-dependent phosphorylation of the beta 2-adrenergic and related G protein-coupled receptors.
(7) Using chimaeric beta ARKs that undergo isoprenylation in vitro, we demonstrate that membrane association and activation of these kinases can occur in the absence of beta gamma.
(8) Purified hamster beta 2AR was phosphorylated by cAMP-dependent protein kinase (PKA), protein kinase C (PKC), or beta AR kinase (beta ARK), and receptor function was determined by measuring the beta 2AR-agonist-promoted Gs-associated GTPase activity.
(9) Although maximal stimulation of beta-subunit phosphorylation was reduced to 30% in proband Ark-1 fibroblasts, this reduction was quantitatively related to reduced insulin binding.
(10) He could flog his fish to the secondhand shop, or maybe sell them on the street, the way his neighbour does stolen trainers, maybe diversifying into Noah’s Arks.
(11) Sir Mark Stanhope, the head of the navy, told the committee that the aircraft carrier Ark Royal and its jumpjet Harriers would have been used to bomb Libya had they not been axed.
(12) Not present at their own trial, or to bear witness to all the controversy generated by their actions, are two key figures in Zoe's Ark: chairman Éric Breteau and his partner Émilie Lelouche.
(13) But my grandfather saw it as the citadel, the Ark; it preserved history, which was his mission.
(14) He receives his orders to build the ark and sets about it.
(15) The Ark by Ralph Erskine, next to the Hammersmith flyover in London, is a large steel-and-glass building, an insect with its wings cut off.
(16) With Ark in place, offering staff better terms of pay and stability that comes with a track record of steering outstanding and good schools, the best teachers were willing to join Conway primary school's little revolution.
(17) This protein tyrosine kinase called ark (adhesion-related kinase) is likely to represent a new class of receptor tyrosine kinase.
(18) The sequence was very similar to that of the bovine beta ARK (the overall amino acid homology was 98%).
(19) G protein beta gamma subunits were shown to interact directly with the COOH-terminal region of beta ARK, and formation of this beta ARK-beta gamma complex resulted in receptor-facilitated membrane localization of the enzyme.
(20) The beta-adrenergic receptor kinase (beta-ARK), which specifically phosphorylates only the agonist-occupied form of the beta-adrenergic and closely related receptors, appears to be important in mediating rapid agonist-specific (homologous) desensitization.
Irk
Definition:
(v. t.) To weary; to give pain; to annoy; -- used only impersonally at present.
Example Sentences:
(1) When the rats were grouped into animals with mild (20%), moderate (50%), and severe (80%) reductions in maximal IRK activity, it was found that the mild and moderate defects could be reversed once the receptors were subjected to extensive autophosphorylation in vitro.
(2) We characterized the mechanism of IRK inhibition and studied whether it is the consequence of a glucose-induced stimulation of protein kinase C (PKC).
(3) 18 May 2014 New £69.4bn proposal, worth £55 a share, piles pressure on AstraZeneca's board to enter negotiations with Pfizer 19 May 2014 AstraZeneca board rejects Pfizer's final £69bn takeover bid , irking some large shareholders
(4) Reports of George’s stag do at Ristorante da Ivo near St Mark’s Square with the free £3,000 meal featuring six flavours of ice cream, including takeaway cartons, initially irked me.
(5) Joleon Lescott last weekend irked supporters by clumsily saying relegation was a “weight off the shoulders”.
(6) Wenger must be the only manager in football to be irked by reports that he will be offered a new deal.
(7) Walking by last Monday, Trump gestured towards an image of his inauguration crowd – a point that still irks him – and told reporters there would soon be an official statement about the future of his national security adviser, Michael Flynn.
(8) Blogger Yomi Adegoke said: "Thinly veiling vanity as philanthropy more than irks … the pretence these images are for anything other than an onslaught of 'natural beauty' acclamations, coupled with pats on the back for 'fighting the cause' makes the no makeup selfie mania even harder to stomach."
(9) We, therefore, conclude that glucose intolerance in aging could be attributed at least in part to acquired defects in the in vivo activation of the hepatic IRK, which results in reduced phosphorylation of its putative substrate pp180.
(10) But while agreeing that the results should not be exaggerated, D'Alimonte still thinks they indicate that the Five Star shine is wearing off among some voters - including those who were irked by the rambunctious figurehead's refusal to support a minority government led by the centre-left Democratic party (PD), thus forcing the PD to form a coalition with Berlusconi's centre-right.
(11) The corporation's power online and expanding digital TV and radio channels have irked beleaguered commercial rivals, resulting in an attack by James Murdoch, head of News Corporation in the UK.
(12) The home crowd turned their ire on the Hungarian referee Viktor Kassai – his decision to dismiss Piiroja for handball in the 76th minute particularly irked them – but they were deluding themselves if they thought he was to blame.
(13) Right now is not the time.” The midfielder refused to be drawn on suggestions that his team-mates were irked by his comments, and insisted the atmosphere among the squad in Brazil was similar to during the glorious Euro 2012 campaign.
(14) Hyperglycemia causes insulin-receptor kinase (IRK) resistance in fat cells.
(15) The comments irked the geologists' professional body, which was founded in 1807 as a dining club in a London pub.
(16) Philip Hammond appears to have irked the prime minister by making a sexist remark in cabinet, exposing the tensions at the highest level of government.
(17) Look, he’s the clear frontrunner, he’s been in six debates already, answered more questions from the media than any other candidate on the stage combined.” The Fox News press release that irked Trump and led to his withdrawal read: “We learned from a secret back channel that the Ayatollah and Putin both intend to treat Donald Trump unfairly when they meet with him if he becomes president – a nefarious source tells us that Trump has his own secret plan to replace the Cabinet with his Twitter followers to see if he should even go to those meetings.” Trump derided it as “a wise guy press release .
(18) To determine whether defects in insulin receptor kinase (IRK) activity or in the phosphorylation of its physiological substrates underlie this age-related phenomenon, young (2-3 months old) and old (24-27 months old) Wistar rats were studied.
(19) Field has already irked the medallion stallion with some low blows before the bell has rung, but it looks doubtful whether punches will be pulled for the number crunchers.
(20) Linehan, who turned 44 last week, is irked by the persistence of the idea that the sitcom that brought him and Arthur Mathews to the attention of millions has canned laughter on it.