(v. t.) To tie, or confine with a cord, band, ligature, chain, etc.; to fetter; to make fast; as, to bind grain in bundles; to bind a prisoner.
(v. t.) To confine, restrain, or hold by physical force or influence of any kind; as, attraction binds the planets to the sun; frost binds the earth, or the streams.
(v. t.) To cover, as with a bandage; to bandage or dress; -- sometimes with up; as, to bind up a wound.
(v. t.) To make fast ( a thing) about or upon something, as by tying; to encircle with something; as, to bind a belt about one; to bind a compress upon a part.
(v. t.) To prevent or restrain from customary or natural action; as, certain drugs bind the bowels.
(v. t.) To protect or strengthen by a band or binding, as the edge of a carpet or garment.
(v. t.) To sew or fasten together, and inclose in a cover; as, to bind a book.
(v. t.) Fig.: To oblige, restrain, or hold, by authority, law, duty, promise, vow, affection, or other moral tie; as, to bind the conscience; to bind by kindness; bound by affection; commerce binds nations to each other.
(v. t.) To bring (any one) under definite legal obligations; esp. under the obligation of a bond or covenant.
(v. t.) To place under legal obligation to serve; to indenture; as, to bind an apprentice; -- sometimes with out; as, bound out to service.
(v. i.) To tie; to confine by any ligature.
(v. i.) To contract; to grow hard or stiff; to cohere or stick together in a mass; as, clay binds by heat.
(v. i.) To be restrained from motion, or from customary or natural action, as by friction.
(v. i.) To exert a binding or restraining influence.
(n.) That which binds or ties.
(n.) Any twining or climbing plant or stem, esp. a hop vine; a bine.
(n.) Indurated clay, when much mixed with the oxide of iron.
(n.) A ligature or tie for grouping notes.
Example Sentences:
(1) Tryptic digestion of the membranes caused complete disappearance of the binding activity, but heat-treatment for 5 min at 70 degrees C caused only 40% loss of activity.
(2) Comparison of the S100 alpha-binding protein profiles in fast- and slow-twitch fibers of various species revealed few, if any, species- or fiber type-specific S100 binding proteins.
(3) Competition with the labelled 10B12 MAb for binding to the purified antigen was demonstrated in sera of tumor-bearing and immune rats.
(4) These studies led to the following conclusions: (a) all the prominent NHP which remain bound to DNA are also present in somewhat similar proportions in the saline-EDTA, Tris, and 0.35 M NaCl washes of nuclei; (b) a protein comigrating with actin is prominent in the first saline-EDTA wash of nuclei, but present as only a minor band in the subsequent washes and on washed chromatin; (c) the presence of nuclear matrix proteins in all the nuclear washes and cytosol indicates that these proteins are distributed throughout the cell; (d) a histone-binding protein (J2) analogous to the HMG1 protein of K. V. Shooter, G.H.
(5) Power urges the security council to "take the kind of credible, binding action warranted."
(6) The binding properties of formalin-fixed amelanotic melanoma cells were not identical to those of endothelial or unfixed target cells.
(7) Such an increase in antibody binding occurred simultaneously with an increase in the fluidity of surface lipid regions, as monitored by fluorescence depolarization of 1-(trimethylammoniophenyl)-6-phenyl-1,3,5-hexatriene.
(8) It has been generally believed that the ligand-binding of steroid hormone receptors triggers an allosteric change in receptor structure, manifested by an increased affinity of the receptor for DNA in vitro and nuclear target elements in vivo, as monitored by nuclear translocation.
(9) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(10) Theoretical computations are performed of the intercalative binding of the neocarzinostatin chromophore (NCS) with the double-stranded oligonucleotides d(CGCG)2, d(GCGC)2, d(TATA)2 and d(ATAT)2.
(11) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(12) It was also able to inhibit the binding both of alpha-bungarotoxin and rabies virus glycoprotein to the acetylcholine receptor.
(13) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(14) The procedure used in our laboratory was not able to provide accurate determination of the concentrations of these binding forms.
(15) The occupation of the high affinity calcium binding site by Ca(II) and Mn(II) does not influence the Cu(II) binding process, suggesting that there is no direct interaction between this site and the Cu(II) binding sites.
(16) PMN were found to be nonpermissive for HSV replication and were unable to bind virus in the absence of antibody.
(17) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(18) The transported pIgA was functional, as evidenced by its ability to bind to virus in an ELISA assay and to protect nonimmune mice against intranasal infection with H1N1 but not H3N2 influenza virus.
(19) The monoclonal antibody (mAb), SY38, binds to a cytoplasmic domain of synaptophysin.
(20) Binding data for both ligands to the enzyme yielded nonlinear Scatchard plots that analyze in terms of four negatively cooperative binding sites per enzyme tetramer.
Shackle
Definition:
(n.) Stubble.
(n.) Something which confines the legs or arms so as to prevent their free motion; specifically, a ring or band inclosing the ankle or wrist, and fastened to a similar shackle on the other leg or arm, or to something else, by a chain or a strap; a gyve; a fetter.
(n.) Hence, that which checks or prevents free action.
(n.) A fetterlike band worn as an ornament.
(n.) A link or loop, as in a chain, fitted with a movable bolt, so that the parts can be separated, or the loop removed; a clevis.
(n.) A link for connecting railroad cars; -- called also drawlink, draglink, etc.
(n.) The hinged and curved bar of a padlock, by which it is hung to the staple.
(v. t.) To tie or confine the limbs of, so as to prevent free motion; to bind with shackles; to fetter; to chain.
(v. t.) Figuratively: To bind or confine so as to prevent or embarrass action; to impede; to cumber.
(v. t.) To join by a link or chain, as railroad cars.
Example Sentences:
(1) They will demand that the shackles be taken off local authorities so they can tackle a homelessness crisis.
(2) Shackles were found in the cellar, and yesterday police found a trap door.
(3) Shackling and ‘a full strip search’ On the morning of 21 October 2013, LaTonia Wilson was pulling out of her mechanic’s garage with her husband, Atheris Mann; her eldest son, Jessie Patrick; and their two-year-old son Marquise.
(4) How Chicago police used pot to disappear young people at Homan Square Read more Davis, a Democrat who represents the neighborhood that includes the Homan Square site, had until Wednesday only said publicly that he would “strongly support” a federal inquiry into what 11 detainees – in strikingly similar detailed accounts provided to the Guardian – have described as extended interrogation without access to legal counsel or their families, often while shackled.
(5) On this evidence, the shackles, in place ever since that World Cup in France, finally appear to be off.
(6) It is modern slavery enforced not through shackles and whips, but by fiddled contracts, missing permits and paperwork and the Guardian has found it happening just down the road from the desert palace of Qatar’s emir, Sheikh Tamim bin Khalifa al-Thani.
(7) Mané, in particular, has become erratic, while Tadic has suffered from the fact that opponents have studied him after his sparkling start to the campaign and increased their efforts to shackle him, partially by curtailing the ability of Southampton’s flying full-backs to support him down the flanks.
(8) Military policy Victory on Sunday will boost attempts by Abe and his fellow conservatives to further loosen the political shackles on Japan’s self-defence forces – actually a highly trained, well-equipped army, navy and air force.
(9) The NHS has experienced numerous attempts to free staff from the shackles of unnecessary paperwork to allow more time for patient care.
(10) The blindfold, shackles, threats and beatings were just the white noise of his ordeal, he says.
(11) Second, its shackled to historicism, constantly looking to the past.
(12) We face the prospect of a week of party manifestos full of reckless promises unbelieved by electors yet shackling future chancellors.
(13) It is so nice that the shackles have been taken off me and I can now fight for America the way I want to,” he tweeted .
(14) I would love to see the selection criteria for that job.’” Facebook Twitter Pinterest From a blindfolded boat ride to threats against his family members and hours shackled to Gitmo floors, Zuley’s interrogation of Mohamedou Ould Slahi shocked investigators.
(15) "He was not only able to break the shackles of bigotry and bias and hate, but he did it without internalising the battles he was fighting."
(16) In March, Gambian president Yahya Jammeh announced plans to throw off the shackles of the colonial past by discontinuing the use of English as an official language .
(17) Sir Edward Leigh, a former minister, said breaking up the coalition would be one way of showing fed-up Conservative voters that Cameron was serious about addressing their concerns, instead of being shackled to the Liberal Democrats .
(18) But even allowing for that fact, and the long-known departure of Lampard, this will undoubtedly be a summer of upheaval for last season’s champions, not least with Uefa looking increasingly likely to loosen the shackles of financial fair play.
(19) Not only are their pay and rations fixed centrally but their revenue is shackled.
(20) When she fled the violence of Honduras and settled with relatives in Atlanta, Gutiérrez, 31, met regularly with immigration officials and wore an electronic ankle shackle, so they could track her.