(n.) The quality or state of being bitter, sharp, or acrid, in either a literal or figurative sense; implacableness; resentfulness; severity; keenness of reproach or sarcasm; deep distress, grief, or vexation of mind.
(n.) A state of extreme impiety or enmity to God.
(n.) Dangerous error, or schism, tending to draw persons to apostasy.
Example Sentences:
(1) Since the election on 7 March there has been a bitter contest for power in Iraq led by Iran, Saudi Arabia and Turkey.
(2) If bitter, pour it out and measure 1.4 litres of water.
(3) The dumplings could also be served pan-fried in browned butter and tossed with a bitter leaf salad and fresh sheep's cheese for a lighter, but equally delicious option.
(4) The first was a passive avoidance task in which the chicks were allowed to peck at a green training stimulus (a small light-emitting diode, LED) coated in the bitter liquid, methylanthranilate, giving rise to a strong disgust response and consequent avoidance of the green stimulus.
(5) In the QHCl-sucrose condition components separated by the tongue's midline and those spatially mixed produced equal amounts of bitterness suppression.
(6) At the interview those with conventional ileostomies expressed better preoperative comprehension of the procedure and more satisfaction about its life-saving nature; nevertheless, they experienced more negative emotional reactions, such as bitterness, after the operation.
(7) The higher analogues of the cycloalkane series containing alpha-aminocycloheptanecarboxylic acid methyl ester and alpha-aminocyclooctanecarboxylic acid methyl ester are bitter.
(8) It's almost starting to feel like we're back in the good old days of July 2005, when Paris lost out to London in the battle to stage the 2012 Olympic Games, a defeat immediately interpreted by France as a bitter blow to Gallic ideals of fair play and non-commercialism and yet another undeserved triumph for the underhand, free-market manoeuvrings of perfidious Albion.
(9) Hollande ended up defending until to the bitter end Jérôme Cahuzac , a finance minister responsible for fighting tax evasion who turned out to have used a secret Swiss bank account to avoid paying taxes in France.
(10) The sensitivity of the taste system to the various qualities was, in decreasing order, salty, sweet, sour, and bitter.
(11) Grace's ascent has also thrown a grenade into the bitter succession battle within Zanu-PF, which Mugabe has divided and ruled for decades.
(12) Denatonium, a very bitter substance, caused a rise in the intracellular calcium concentration due to release from internal stores in a small subpopulation of taste cells.
(13) I see myself in exactly the same situation as I saw myself yesterday, though obviously with the bitter disappointment of the failure of being knocked out.
(14) Stephen Joseph, its chief executive said: "This is bitter news for everyone who relies on the train to get to work, not least the large number of commuters in marginal constituencies who will be a key group at the next election."
(15) Lewis Wind Power, the joint venture company set up by Amec and British Energy, said it was "bitterly disappointed" by the decision.
(16) As night fell in Paris, despite the bitter cold, more than 5,000 people gathered under the imposing statue of Marianne, the symbol of the republic, to show their anger, grief and solidarity.
(17) The present alternative model of health care in China has evolved after prolonged and often bitter debate extending over twenty years.
(18) It is much less soluble and bitter and poses few stability problems when capsulated or tableted with aspirin.
(19) "They have given Mexicans the most bitter Christmas," Armando Martínez, the president of the College of Catholic Attorneys, told reporters.
(20) He says he is not bitter but his words are laced with hostility.
Spite
Definition:
(n.) Ill-will or hatred toward another, accompanied with the disposition to irritate, annoy, or thwart; petty malice; grudge; rancor; despite.
(n.) Vexation; chargrin; mortification.
(v. t.) To be angry at; to hate.
(v. t.) To treat maliciously; to try to injure or thwart.
(v. t.) To fill with spite; to offend; to vex.
Example Sentences:
(1) In spite of dense lymphocytic infiltration only 3% of the tumor infiltrating lymphocytes exhibit the activation marker CD 25.
(2) When labelled long-chain fatty acids or glycerol were infused into the lactating goat, there was extensive transfer of radioactivity into milk in spite of the absence of net uptake of substrate by the mammary gland.
(3) In spite of important differences in size, chemical composition, polymer density, and configuration, biological macromolecules indeed manifest some of the essential physical-chemical properties of gels.
(4) Mastitis in its complexity has managed to forestall all efforts of eradication in spite of years of research, antibiotics and practical control measures.
(5) In spite of antimalaria treatment, with cortisone and then with immuno-depressants, the outcome was fatal with a picture of acute reticulosis and neurological disorders.
(6) In spite of the presence of scar tissue following rhytidectomy, this procedure has been quite successful because of the rich blood supply in that area.
(7) By the GN of non-streptococcal etiology, AA's to the BLSE apparently of other specificity are obtained in some cases, in spite of the absence of antibodies to A-PS.
(8) In spite of the formation of the epoxide intermediate, no binding of [14C]d-limonene equivalents to mouse kidney proteins was observed.
(9) No cases of rheumatic fever and no acute nephritis appeared in spite of the vigorous immune response to both cellular and extracellular antigens of group A streptococci documented in 50% to 80% of patients, suggesting that strain variation may be a feature of rheumatogenicity as well as nephritogenicity of group A streptococcal pharyngitis.
(10) Clinical and inflammatory activity improved in both groups, but consistently more so in the auranofin group, in spite of the greater consumption of local steroids and NSAIDs in the placebo group.
(11) The reported case of fetal infection in spite of previous rubella vaccination of the mother does not discourage the use of rubella vaccine.
(12) Although operative mortality was significantly greater for women during most of this review period, mortality was similar during 1983 (2.6% for men versus 2.4% for women), in spite of a significantly higher incidence of unstable angina in the female group (54% for women versus 35% for men).
(13) The shapes of the curves for soleus and tibialis anterior are similar in spite of the different mechanical conditions of the two muscles.
(14) In spite of the limitations arising from the complex geometry of the right ventricule, echocardiography may be the most important non-invasive technique in the evaluation of the structural and functional repercussion of hypertension on the right ventricle.
(15) Thus, in spite of its excellent activity and unquestionable effectiveness, rifampicin should be used with caution in severe staphylococcal infections.
(16) My son was born healthy, strong and very handsome, in spite of his dangerous start.
(17) The great clinical value of the procedure is shown by the following findings:X-ray-negative lesions--including 2 cases of carcinoma--were found in 35 percent of the cases, radiologically demonstrated lesions could be defined more precisely in 18 percent, and the presence of colonic lesions could be ruled out in 11 percent in spite of equivocal X-ray findings.
(18) In spite of low fluoride content in their water supply, the findings revealed a generally low prevalence of caries experience (DMFT 1.26).
(19) In anesthetized cats, the enhancement of sympathetic activity and increase of the blood pressure in exclusion of afferents (section of vagosympathetic trunks and clamping of common carotid arteries) as well as the disappearance of the activity in enhanced afferentation, were shown to be transient and to disappear within a few minutes-scores of minutes in spite of the going on deafferentation or enhancement of afferentation.
(20) By modifying the spatial distribution of afferents to the network, we demonstrate that the same basic model functions properly in spite of afferents with nonuniform background firing rates.