(n.) The lowest part of anything; the foot; as, the bottom of a tree or well; the bottom of a hill, a lane, or a page.
(n.) The part of anything which is beneath the contents and supports them, as the part of a chair on which a person sits, the circular base or lower head of a cask or tub, or the plank floor of a ship's hold; the under surface.
(n.) That upon which anything rests or is founded, in a literal or a figurative sense; foundation; groundwork.
(n.) The bed of a body of water, as of a river, lake, sea.
(n.) The fundament; the buttocks.
(n.) An abyss.
(n.) Low land formed by alluvial deposits along a river; low-lying ground; a dale; a valley.
(n.) The part of a ship which is ordinarily under water; hence, the vessel itself; a ship.
(n.) Power of endurance; as, a horse of a good bottom.
(n.) Dregs or grounds; lees; sediment.
(a.) Of or pertaining to the bottom; fundamental; lowest; under; as, bottom rock; the bottom board of a wagon box; bottom prices.
(v. t.) To found or build upon; to fix upon as a support; -- followed by on or upon.
(v. t.) To furnish with a bottom; as, to bottom a chair.
(v. t.) To reach or get to the bottom of.
(v. i.) To rest, as upon an ultimate support; to be based or grounded; -- usually with on or upon.
(v. i.) To reach or impinge against the bottom, so as to impede free action, as when the point of a cog strikes the bottom of a space between two other cogs, or a piston the end of a cylinder.
(n.) A ball or skein of thread; a cocoon.
(v. t.) To wind round something, as in making a ball of thread.
Example Sentences:
(1) In the far east is the arid, depressed country leading down Hell’s Canyon, which bottoms out at the Snake River, which the wolves crossed when they moved from Idaho, and which they now treat more as a crosswalk than a barrier.
(2) It was one of a series of deaths of black men – deaths in custody, deaths where no one ever got to the bottom of what had happened.
(3) The bottom line is that access to abortion is a matter of social justice.
(4) I could walk around more freely than in North Korea, but it was very apparent I was being watched.” The country consistently sits at the bottom of global freedom rankings, in the company of North Korea and Eritrea.
(5) At the bottom is a tiny harbour where cafe Itxas Etxea – bare brick walls and wraparound glass windows – is serving txakoli, the local white wine.
(6) "The results present a remarkably bleak portrait of life in the UK today and the shrinking opportunities faced by the bottom third of UK society," said the head of the project, Professor David Gordon of Bristol University.
(7) In the dance off tomorrow should be Dave and Karen and Mark and Iveta, but it wouldn't surprise me if Fiona and Anton were in the bottom two instead.
(8) With grievous amazement, never self-pitying but sometimes bordering on a sort of numbed wonderment, Levi records the day-to-day personal and social history of the camp, noting not only the fine gradations of his own descent, but the capacity of some prisoners to cut a deal and strike a bargain, while others, destined by their age or character for the gas ovens, follow "the slope down to the bottom, like streams that run down to the sea".
(9) In some cases, a change in the type of bottom resulted in the opposite order of rates for vessels with the same diameter.
(10) 10.34pm BST Rays 2 - Red Sox 8, bottom of the 6th David Ortiz leads off the inning against Chris Archer, still in the game, he grounds into the Maddon shift.
(11) As is frequently the case, the bottom line in preventing and treating intra-abdominal adhesions is appropriate surgical technique.
(12) Companies like Origin and EnergyAustralia are pushing to weaken the target not, as they like to claim, because that would be good for customers, but because a weaker target is better for their bottom line,” Connor said.
(13) You can be very cosy with someone but, at the end of the day, it’s about the bottom line.
(14) The satellite component is not found when digging up from the tube bottom.
(15) The calibrated aperture in the bottom of each well is small enough to retain fluid contents by surface tension during monolayer growth, but also permits fluid to enter the wells when transfer plates are lowered into receptacles containing washing buffer or test sera.
(16) When you are informed that 200 children are missing, you don’t go to dinner until you have got to the bottom of it.
(17) That is the bottom line.” Others described the need for a policy of containing Iran, especially with the lifting of economic sanctions.
(18) In order to study the effects of different glass ionomers on the metabolism of Streptococcus mutans, test slabs of freshly mixed conventional glass ionomer (Fuji), silver glass ionomer (Ketac-Silver), composite (Silux), and 2-week-old Fuji were fitted into the bottom of a test tube.
(19) The plates were viewed directly in an inverted UV microscope or were inspected and photographed bottoms up with a conventional UV microscope mounted with an old-fashioned uncorrected objective (20 X) which, because of its shorter length, permitted proper focussing.
(20) That's why the policies that are desperately needed for the majority to break the grip of a failed economic model would also help make regulated migration work for all: stronger trade unions, a higher minimum wage, a shift from state-subsidised low pay to a living wage, a crash housing investment programme, a halt to cuts in public services, and an end to the outsourced race to the bottom in employment conditions.
Substrate
Definition:
(n.) A substratum.
(a.) Having very slight furrows.
(v. t.) To strew or lay under anything.
Example Sentences:
(1) 5-HT thus appears to be the preferred substrate for uptake into platelets and for movement from cytoplasm to vesicles.
(2) Some common eye movement deficits, and concepts such as 'the neural integrator' and the 'velocity storage mechanism', for which anatomical substrates are still sought, are introduced.
(3) These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens.
(4) The common polyamines, spermidine and spermine, and histones were not substrates.
(5) Manometric studies with resting cells obtained by growth on each of these sulfur sources yielded net oxygen uptake for all substrates except sulfite and dithionate.
(6) The PSB dioxygenase system displayed a narrow substrate range: none of 18 sulphonated or non-sulphonated analogues of PSB showed significant substrate-dependent O2 uptake.
(7) The observed relationship between prorenin and renin substrate concentrations might be a consequence of their regulation by common factors.
(8) This theory was confirmed by product analysis and by measuring the affinity of the substrate for the enzyme by its inhibition of p-nitrophenyl glucoside hydrolysis.
(9) Yields of Thiobacillus dentrificans on different substrates were compared.
(10) It includes preincubation of diluted plasma with ellagic acid and phospholipids and a starting reagent that contains calcium and a chromogenic peptide substrate for thrombin, Tos-Gly-Pro-Arg-pNA.
(11) The present results provide no evidence for a clear morphological substrate for electrotonic transmission in the somatic efferent portion of the primate oculomotor nucleus.
(12) Fluorination with [18F]acetylhypofluorite yields 6-[18F]fluoro-L-dopa with 95% radiochemical purity; fluorination of the same substrate with [18F]F2 yields a mixture of all three structural isomers in a ratio of 70:16:14 for 6-, 5-, and 2-fluoro compounds.
(13) The enzyme, when assayed as either a phospholipase A2 or lysophospholipase, exhibited nonlinear kinetics beyond 1-2 min despite low substrate conversion.
(14) The stopped-flow technique was used to measure the rate constants for the reactions between the oxidized forms of peroxidase with luminol and the following substrates: p-iodophenol, p-bromophenol, p-clorophenol, o-iodophenol, m-iodophenol, luciferin, and 2-iodo-6-hydroxybenzothiazole.
(15) The time-course and dose-response for this modification of pp60c-src paralleled PDGF-induced increases in phosphorylation of pp36, a major cellular substrate for several tyrosine-specific protein kinases.
(16) Control incubations revealed an inherent difference between the two substrates; gram-positive supernatants consistently contained 5% radioactivity, whereas even at 0 h, those from the gram-negative mutant released 22%.
(17) Uptake could be supported either by substrate oxidation or by adenosine 5'-triphosphate (ATP), and was inhibited in the former case by antimycin or cyanide, in the latter case by oligomycin, and in both cases by 2,4-dinitrophenol.
(18) These results indicate that both the renal brush-border and basolateral membranes possess the Na(+)-dependent dicarboxylate transport system with very similar properties but with different substrate affinity and transport capacity.
(19) Congenitally deficient plasmas were used as the substrate for the measurement of procoagulant activities in a one-stage clotting assay.
(20) This capacity is expressed during incubation of the bacteria with the substrate and needs a source of carbon and other energy metabolites.