(1) This peptide is equivalent to the cDNA-derived sequence 468-476 of Ca2+-ATPase [Brandl et al.
(2) Altogether, nine inhibitory antibodies were produced: six of these inhibitory antibodies mapped to the same spatial region, although they appear to bind to two distinct epitopes located within the hinge region and the nucleotide-binding domains of current structural models; one antibody bound to an epitope located within the phosphorylation domain and the stalk-transmembranous region designated M4S4 by Brandl, Green, Korczak & MacLennan [(1986) Cell 44, 597-607].
(3) In contrast, application of 100.0 MPa to the calcium-transport enzyme at room temperature accelerates subsequent tryptic cleavage at the T2 but not at the T1 cleavage site [C. J. Brandl et al.
(4) This additional exon shifts the exon encoding the neonatal carboxyl-terminal sequence, -Asp-Pro-Glu-Asp-Glu-Arg-Arg-Lys (Brandl, C. J., Green, N. M., Korczak, B., and MacLennan, D. H. (1986) Cell 44, 597-607) into a nontranslated region and results in the expression of an adult isoform with a carboxyl-terminal -Gly.
(5) The cDNA (termed FCa) comprised 3,239 base pairs, including an open reading frame encoding 994 amino acids which showed the highest degree of homology with the adult rabbit fast-twitch Ca2+-ATPase isoform (C. J. Brandl, S. de Leon, D. R. Martin, and D. H. MacLennan, J. Biol.
(6) The N-terminal sequence of this peptide, (Trp)-Phe-Met-Tyr-Ala, forms the basis for an oligodeoxynucleotide probe, the use of which to identify cDNA corresponding to the ATPase is described elsewhere [MacLennan, Brandl, Korczak & Green (1985) Nature (London) 316, 696-700].
(7) These results question an earlier proposition that Ca2(+)-binding is located to the "stalk" region of Ca2(+)-ATPase (Brandl, C. J., Green, N. M., Korczak, B., and MacLennan, D. H.) (1986) Cell 44, 597-607) but are in agreement with recent data obtained by oligonucleotide-directed mutagenesis of Ca2(+)-ATPase (Clarke, D. M., Loo, T. W., Inesi, G., and MacLennan, D. H. (1989) Nature 339, 476-478).
(8) The observed calcium fluxes are attributed to a slow channel formed by ATPase transmembrane helices (MacLennan, D. H., Brandl, C. J., Korczak, B., and Green, N. M. (1985) Nature 316, 686-700) and are capable of long range interaction with the catalytic site.
(9) In a previous study (Brandl, C. J., de Leon, S., Martin, D. R., and MacLennan, D. H. (1987) J. Biol.
(10) Domain I (Tm = 50 degrees C) consists of the nucleotide binding region and most likely the phosphorylation and transduction regions [MacLennan, D. H., Brandl, C. J., Korczak, B., & Green, N. M. (1985) Nature 316, 696-700].
(11) Both of these sequences were found in the amino acid sequence of Ca2+-transporting ATPase (Brandl et al.
(12) Pointing out that a vaccine is not expected in the short term, PAHO's Dr. David Brandling-Bennet stressed that the fight against AIDS depends on disseminating information.
(13) These results are consistent with, and support, our model for folding of the Ca2(+)-ATPase (Brandl, C. J., Korczak, B., Green, N. M., and MacLennan, D. H. (1986) Cell 44, 597-607) in which residues 657-672 were proposed to form part of the cytoplasmic nucleotide binding domain, while residues 870-890 were proposed to form a luminal loop between proposed transmembrane sequences M7 and M8.
Parr
Definition:
(n.) A young salmon in the stage when it has dark transverse bands; -- called also samlet, skegger, and fingerling.
(n.) A young leveret.
Example Sentences:
(1) Unlike many music hack days, this is a commercial contest: the winning hack – as judged by Slash, BitTorrent founder Bram Cohen and investor Ben Parr – will earn its creator an autographed guitar, $1,000 and “the chance to have Slash use the winning hack with the release of his new album”.
(2) The sale should be stopped unless the bank’s special status is protected.” Doug Parr, policy director at Greenpeace, added: “A Green Investment Bank that is privatised needs to have its green credentials written in stone.
(3) The wave functions of the bases are computed by Pariser--Parr--Pople's method taking into account all the singly excited configurations.
(4) Friend leukemia complex (FLC), and Rowson-Parr virus (RPV) infections of donor mice depress the production of background antibody-forming cells by splenocytes cultured in the absence of specific antigenic stimulation.
(5) Writing about Tulsa in The Photobook Volume 1 , authors Martin Parr and Gerry Badger say that the "incessant focus on the sleazy aspect of the lives portrayed, to the exclusion of almost anything else – whether photographed from the 'inside' or not – raises concerns about exploitation and drawing the viewer into a prurient, voyeuristic relationship with the work."
(6) Serum cortisol concentrations were measured in juvenile Atlantic salmon (Salmo salar L.) undergoing the parr-smolt transformation in fresh water, at either 1 year (S1 population) or 2 years (S2 population) after hatching.
(7) The Nigeria international won a penalty in the dying minutes when he was brought down by Jonathan Parr, enabling Hatem Ben Arfa to complete the scoring.
(8) Craig Parr, secondary school teacher, London I think this is partly about ensuring teachers have the freedom to get on with the job.
(9) To obtain more information on the role of prolactin and growth hormone during the parr-smolt transformation of Atlantic salmon, a population of fish in fresh water was sampled from January to June during two consecutive years.
(10) Dr Doug Parr, chief scientist at Greenpeace UK, said: "We're pleased to see the growing recognition that our inefficient, centralised electricity grid is losing over half of its energy in waste heat.
(11) Doug Parr, Greenpeace UK's chief scientist, welcomed the proposals.
(12) Increased glycogen and lipid breakdown, and concomitant decreased glycogen and fatty acid synthesis would contribute to the lipid and glycogen depletion observed in salmonid species undergoing parr-smolt transformation.
(13) The status of circulating growth hormone and prolactin during the parr-smolt transformation and during seawater adaptation of coho salmon (Oncorhynchus kisutch) was investigated in relation to changes in plasma levels of thyroxine, triiodothyronine, and cortisol, and in hypoosmoregulatory ability.
(14) In the mature male parr, plasma GH levels increased after 24 hr, when the levels were almost five times those of the freshwater controls.
(15) They seriously threatened only twice – David de Gea saving in a cluttered first half when Chris Smalling diverted a Jonathan Parr header goalwards and then denying Cameron Jerome, on as a substitute, an equaliser shortly after Van Persie's goal – and remain two points above the bottom three.
(16) With a foreword by Martin Parr , the man who matters most in the world of the photobook, it arrived in Arles with buzz attached from the recent photobook festival at Bristol co-curated by Parr.
(17) Evidence of the core domain-domain interaction to stabilize the Fe-S bond, combined with the kinetic studies by G. R. Parr and H. Taniuchi, has led to a model of two alternative folding orders of the core domains for the horse type I complex: domain 1----3----2----4 or 1----2----3----4.
(18) To elucidate the ultrastructural modifications of the gill epithelium during smoltification, gills of the Atlantic salmon (Salmo salar) were examined by electron microscopy at three stages of this process, which were defined as follows: "parrs" were freshwater fish that had not yet started their transformation; "freshwater smolts" were freshwater fish that were ready to enter seawater; and "seawater smolts" were smolts that had been transferred from fresh water and maintained for 4 days in seawater (35%).
(19) T4 and cortisol treatment stimulated lipid mobilization in parr.
(20) These results implicate thyroid hormones in the expression of adult forms of hemoglobin during the parr to smolt transformation of juvenile salmon.