(n.) The fore part of the body, between the neck and the belly; the chest; as, the breast of a man or of a horse.
(n.) Either one of the protuberant glands, situated on the front of the chest or thorax in the female of man and of some other mammalia, in which milk is secreted for the nourishment of the young; a mamma; a teat.
(n.) Anything resembling the human breast, or bosom; the front or forward part of anything; as, a chimney breast; a plow breast; the breast of a hill.
(n.) The face of a coal working.
(n.) The front of a furnace.
(n.) The seat of consciousness; the repository of thought and self-consciousness, or of secrets; the seat of the affections and passions; the heart.
(n.) The power of singing; a musical voice; -- so called, probably, from the connection of the voice with the lungs, which lie within the breast.
(v. t.) To meet, with the breast; to struggle with or oppose manfully; as, to breast the storm or waves.
Example Sentences:
(1) This effect was more marked in breast cancer patients which may explain our earlier finding that women with upper body fat localization are at increased risk for developing breast cancer.
(2) Breast reconstruction should not be limited to the requiring patients, but should represent, in selected cases with favourable prognosis, an integrative and complementary procedure of the treatment.
(3) Breast conserving surgery in patients with small tumors combined with radiation therapy has gained wide popularity due to better cosmetic results without significant changes in survival.
(4) Breast temperatures have been measured by the automated instrumentation called the 'Chronobra' for 16 progesterone cycles in women at normal risk for breast cancer and for 15 cycles in women at high risk for breast cancer.
(5) In contrast, human breast milk contained substantially increased levels of immunoreactive PTHrP.
(6) Early detection of breast cancer is the major indication, and mammography is the single best test for this task.
(7) PAF was found in almost all carcinoma, although it was not detected in most of the matched, nontumor breast tissue samples.
(8) A case-control study of breast cancer among Black American women was conducted in seven hospitals in New York City from 1969 to 1975.
(9) He stressed the importance of the motivation to the mother for breast feeding and the independence between levels of instruction and frequency of breast feeding.
(10) Odds ratios were computed by multiple logistic regression analysis and revealed no additional relationships; however, there were suggested dose-response gradients for height, weight at age 20, and body surface area in the Japanese women and for breast size in the Caucasian women.
(11) 10 women in the study developed carcinoma in the same or opposite breast within 16-20 years, a rate of incidence 480% greater than among the general population of women of the same age.
(12) The ability of ligand to stimulate its own synthesis and that of its receptor suggests the presence of an autocrine positive feedback loop, however we were unable to break this loop in the breast cancer cells by antibodies that blocked the interaction of TGF alpha with the EGF receptor.
(13) The most frequent primary tumours were: carcinoma of the breast (37%), lung (25%), kidney (16%), rectum (9%).
(14) Zinc alpha-2 glycoprotein (ZnGP) was measured in human breast microcysts, breast secretions, breast cyst fluid and serum.
(15) Minimal breast cancer should include lobular carcinoma in situ (lobular neoplasia) and ductal carcinoma in situ regardless of nodal status, and (tentatively) invasive carcinoma smaller than 1 cm in total diameter, if axillary lymph nodes are not involved.
(16) After an introductory note on primary preventive intervention of breast cancer during adulthood, the author defends and extends a hypothesis that relates most of the known risk factors for this disease to the development of preneoplastic lesions in the breast.
(17) The degree of discomfort was slightly greater in women who complained of breast tenderness within three days prior to the mammogram but was not strongly related to age, menstrual status, or week of the menstrual cycle.
(18) Advanced breast cancer responds to a range of cytotoxic agents, but resistance always develops.
(19) The concentration of potassium (K+) and sodium (Na+) was measured in breast cyst fluid (BCF) from 611 cysts greater than 3 ml aspirated in 520 women with gross cystic disease of the breast.
(20) Luminal and myoepithelial cells have been separated from normal adult human breast epithelium using fluorescence activated cell sorting.
Cleavage
Definition:
(n.) The act of cleaving or splitting.
(n.) The quality possessed by many crystallized substances of splitting readily in one or more definite directions, in which the cohesive attraction is a minimum, affording more or less smooth surfaces; the direction of the dividing plane; a fragment obtained by cleaving, as of a diamond. See Parting.
(n.) Division into laminae, like slate, with the lamination not necessarily parallel to the plane of deposition; -- usually produced by pressure.
Example Sentences:
(1) It is possible that the high level of radiolabeled phospholipid found in the plasma membrane arose via the de novo pathway following the cleavage of an acyl group as we have found cytidine diphosphocholine phosphotransferase in the plasma membrane fraction (Wang, P., DeChatelet, L.R., and Waite, M. (1977) Biochim.
(2) Release of nsP4 from P1234 appears to be independent of the other cleavages and occurs primarily immediately after translation.
(3) A broad specificity of LipDH was observed for the glycine cleavage system.
(4) It is the action of this protease that releases the enzyme from the membrane, as shown by the observations that protease inhibitors decreased the amount of solubilization of the enzyme, and the enzyme remaining in the membrane after heating showed much less proteolytic cleavage than that which was released.
(5) One of the proteases obtained was found to catalyse cleavage on the COOH-side of peptide sequences containing consecutive hydrophobic and basic residues.
(6) The results show that in both viral DNAs cleavage occurs at the origin and at one additional site which shows striking sequence homology with the origin region.
(7) These results would suggest that N-terminal acetylation and C-terminal proteolytic cleavage are important post-translational modifications of the forms of Amia beta-endorphin.
(8) We speculate that this cleavage event is catalyzed by either a cryptic potyviral proteinase that requires a host factor or subcellular environment for activation, or possibly a host proteinase.
(9) The relative cleavage frequency at the first glycosidic bond counting from the nonreducing end of the substrate increases with increasing substrate concentration.
(10) An analysis of the triple helical stabilities of these cleavage site regions as reflected by their imino acid contents fails to yield a correlation between reactivity and triple helical stability.
(11) We found that the closer location of Mg2+ to the beta-phosphoryl group than to the alpha- or gamma-phosphoryl group was effective in weakening the P-O bond at which the cleavage of ATP catalyzed by most enzymes takes place.
(12) Subsequently, due to the rotation of the original polar axis in one hemisphere, the third cleavage plane through one half of the egg is transverse to the third cleavage plane through the other half.
(13) It is concluded that in this cell type (i) somatostatin-14 is exclusively generated by dibasic cleavage at the Arg-2-Lys-1 site of the intact precursor with concomitant production of prosomatostatin[1-76], and (ii) no direct interactions between the monobasic and dibasic processing domains occur.
(14) The amount of cleavage products depends on the excess of H2O2 used.
(15) To determine which enzymes are responsible for the processing cleavages of ribosomal RNA transcripts in Escherichia coli, we constructed a mutant strain lacking RNAase III and containing a thermolabile RNAase P. At the nonpermissive temperature, this strain accumulates a novel "19S" RNA species which contains 17S precursor rRNA sequences covalently linked to tRNA sequences transcribed from the ribosomal RNA spacer region between the 16S and the 23S rRNA cistrons.
(16) The cleavage of beta-cyclodextrine by sodium periodate at the seven 2-3 diols of the glucose unit gives rise to the polyaldehyde 1, used to modify alpha-amylase.
(17) The possibility that mammalian DNA topoisomerase II is an intracellular target which mediates drug-induced DNA breaks is supported by the following studies using 4'-(9-acridinylamino)methane-sulfon-m-anisidide (m-AMSA): (a) a single m-AMSA-dependent DNA cleavage activity copurified with calf thymus DNA topoisomerase II activity at all chromatographic steps of the enzyme purification; (b) m-AMSA-induced DNA cleavage by this purified activity resulted in the covalent attachment of protein to the 5'-ends of the DNA via a tyrosyl phosphate bond.
(18) This single substitution was sufficient to abolish all detectable cleavage of the gp160 envelope precursor polypeptide as well as virus infectivity.
(19) Certain RNA molecules can mediate their own cleavage or splicing or act as enzymes to promote reactions on substrate RNA molecules.
(20) The envelope glycoprotein of human immunodeficiency virus consists of two subunits, designated gp120 and gp41, derived from the cleavage of a precursor polypeptide gp160.