(a.) Producing, or attended with distress and misery; making wretched; wretched; unhappy.
Example Sentences:
(1) Such views are increasingly common all over Detroit, the forlorn former capital of America's car industry and now a by-word for calamitous urban decline.
(2) Opening heroin consumption rooms We have spent nearly 50 calamitous years treating drug addiction as a criminal justice matter rather than a social and medical problem.
(3) If that attitude could sometimes frustrate senior editors’ desire to raise standards – if it could, in the end, be blamed for the calamitous failure to spot the misdeeds of Johann Hari – it was also the only thing that kept the paper from falling apart completely: an irresistibly romantic underdog spirit, a sense that since this plainly wasn’t a viable business, it had to be a cause.
(4) That spirit of co-operation represents a drastic change from the calamitous Copenhagen climate summit in 2009, when diplomatic snubs and general distrust between the two countries wrecked any prospect for a deal.
(5) Without them, it would be like the calamitous three-day service outage of October 2011 – permanently.
(6) His seventh goal in his last seven games for Wales, after a calamitous mistake from Radja Nainggolan, was the difference on a evening that ended with the Real Madrid forward leaving the field to a standing ovation two minutes from time.
(7) As ruthless as Liverpool were with their finishing, in particular the irrepressible Luis Suárez , who scored twice to take his tally for the season to 22, Stoke were guilty of some calamitous defending and contributed largely to their own downfall.
(8) While calamitous action unfolds on screen, Green imparts anecdotes, socio-political analysis and the kind of life advice you might expect from his day-job as a best selling author and progressive digital campaigner.
(9) Rather than boasting of calamitous missions, the politicians responsible for them must be held to account.
(10) Second-chance Sunday in Gosford In truth, Justin Pasfield’s calamitous goalkeeping against Newcastle last week was about as cringe-worthy as his new hipster beard-haircut combination.
(11) Blair’s calamitous war in Iraq and Cameron’s radical domestic agenda implemented in a hung parliament are cited as examples of mighty power exerted against the will of the people.
(12) They’re a pro-X Factor paper.” But his book arguably also proves the alternative explanation for his calamitous public image.
(13) This is not to say that I think his presidency has been without its serious, even calamitous, failures, the most important of which is his unwillingness to intervene in any meaningful way in Syria.
(14) You would expect newspaper sales to drop in August as readers head for the beaches, so the important comparison is the year-on-year figures which range from catastrophic to calamitous.
(15) Referring repeatedly to “our friends and allies in the EU”, the prime minister added she had no interest in the bloc unravelling: “It remains overwhelmingly and compellingly in Britain’s national interest that the EU should succeed.” But she warned that if the EU 27 heeded those “voices calling for a punitive deal that punishes Britain”, it would amount to “an act of calamitous self-harm for the countries of Europe.
(16) The Kensington and Chelsea council leader, Nick Paget-Brown, stepped down on Friday along with his deputy following another calamitous week that included a bungled attempt by the council to hold a cabinet meeting behind closed doors.
(17) The victors will have a home tie against Watford, who scraped past Leeds thanks to a calamitous Scott Wootton own goal.
(18) But it wasn't just on the war on terror that opponents of the New World Order were shown to be right and its cheerleaders to be talking calamitous nonsense.
(19) Previous research has shown three quarters of the world’s listed reserves of carbon producing fuels must stay in the ground if the world is to avoid calamitous climate change.
(20) "Fears about growth in Europe, Asia and the US, where calamitous existing home sales figures were the focus...
Detriment
Definition:
(n.) That which injures or causes damage; mischief; harm; diminution; loss; damage; -- used very generically; as, detriments to property, religion, morals, etc.
(n.) A charge made to students and barristers for incidental repairs of the rooms they occupy.
(v. t.) To do injury to; to hurt.
Example Sentences:
(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.