(1) The promoters of the adenovirus 2 major late gene, the mouse beta-globin gene, the mouse immunoglobulin VH gene and the LTR of the human T-lymphotropic retrovirus type I were tested for their transcription activities in cell-free extracts of four cell lines; HeLa, CESS (Epstein-Barr virus-transformed human B cell line), MT-1 (HTLV-I-infected human T cell line without viral protein synthesis), and MT-2 (HTLV-I-infected human T cell line producing viral proteins).
(2) The clinical presentation of the disease and the results of treatment in 48 patients with metastases at diagnosis of Ewing's sarcoma, entered into the Cooperative Ewing's Sarcoma Studies (CESS) 1981 and 1986 of the German Society of Pediatric Oncology (GPO), were analysed.
(3) These results are similar to those obtained in 59 patients treated from 1979 to 1982 (average follow-up, 10 years) using the same drugs administered according to adjuvant chemotherapy procedure as well as those reported in the only other large study on this subject in the literature (the multi-institution German study CESS-81).
(4) By this method, preoperative localization of the insulin producing pancreatic islet cell tumor was su-cessfully performed.
(5) The same DNA fragment directed cell-specific transcription of the IL-2 receptor gene in extract of HTLV-I-infected T cells, MT-1, but not of Epstein-Barr virus-transformed B cells, CESS.
(6) MSF said case numbers had dropped in the Liberian capital, Monrovia, where there was now surplus bed capacity, but added that many international agencies “seem unable to adapt to the rapidly changing situation” with outbreaks in Bong, Margibi, Gbarpolu, Grand Cape Mount and River Cess counties.
(7) The toxicity of the VAIA regimen was comparable with that of the conventional vincristine, actinomycin D, cyclophosphamide, and adriamycin (VACA) regime used in the previous CESS 81 trial.
(8) Histamine increases the IL-6 binding by CESS cells and inhibits that by U937 and HepG2 cells.
(9) In CESS 86, however, the results after radiation therapy have been improved markedly (3-year RFS 67% after radiation therapy, 65% after surgery, and 62% after resection plus irradiation).
(10) The effects of the supernatants obtained from culture fluids of the ATL cells and the T-cell lines on IgG production of a human B-cell line, CESS cells, were also examined.
(11) IgA-specific suppressive activity was absorbed with human B blastoid cells bearing surface IgA (Dakiki) but not with those bearing surface IgG (CESS) or murine and human T cell line cells (BW5147, L5178Y, HPB-ALL, and MOLT4), indicating that IgA-BF interact with B cells bearing IgA to suppress their differentiation.
(12) In contrast, PA317 and GH3 IL 6 were 230 and 6.7 times more effective than COS-7 IL 6 in inducing Ig production in CESS cells.
(13) Supernatant from the human bladder carcinoma line T-24 contains a B-cell differentiation factor (BCDF) able to induce immunoglobulin secretion from CESS cells.
(14) At present, Kaplan-Meier disease-free survival projects that disease-free survival in patients with large primary tumors has improved compared with that reported for the previous CESS 81 trial.
(15) Supernatants (Sups) of culture fluids of ATL cells from 4 patients and those of 2 T-cell lines were added at various concentrations to the CESS cells.
(16) IL-6 was found 1 degree to stimulate immunoglobulin A production by the CESS B cell line up to 19 fold without being affected by the presence of IL-1 beta and 2 degrees to stimulate murine thymocytes proliferation up to 2-4 fold, with an increase up to 60-fold in costimulation with either IL-1 alpha or beta.
(17) CESS, L4 and BALM4 all increased IgG production in response to partially purified B cell growth factor (Cellular Products, Inc., Sera-Lab., Crawley Down, GB) and B cell differentiation factor-containing supernatant from the T24 bladder carcinoma cell line.
(18) Studies of Ebstein-Barr virus-transformed B cell lines showed that IFN-alpha caused a similar effect on the CESS line as on peripheral blood B cells, with low dose enhancement and high dose suppression of Ig production.
(19) A low-frequency suppressor-cell population in normal peripheral blood inhibits the B-cell CESS response to IL-6, following pokeweed mitogen stimulation.
(20) When SPL were cultured with OK-432 for 24 h in serum-free T medium, the cell-free supernatant induced production of IgM in the SKW6.CL-4 and IgG in the CESS human B cell line, while no such activity was detected in unstimulated SPL culture.
Neglect
Definition:
(adv.) Not to attend to with due care or attention; to forbear one's duty in regard to; to suffer to pass unimproved, unheeded, undone, etc.; to omit; to disregard; to slight; as, to neglect duty or business; to neglect to pay debts.
(adv.) To omit to notice; to forbear to treat with attention or respect; to slight; as, to neglect strangers.
(v.) Omission of proper attention; avoidance or disregard of duty, from heedlessness, indifference, or willfulness; failure to do, use, or heed anything; culpable disregard; as, neglect of business, of health, of economy.
(v.) Omission if attention or civilities; slight; as, neglect of strangers.
(v.) Habitual carelessness; negligence.
(v.) The state of being disregarded, slighted, or neglected.
Example Sentences:
(1) Previous use of the drug is found in more than 50 per cent of the patients, and it was often followed by a neglected side-effect.
(2) Unfortunately, due to confidentiality clauses that have been imposed on us by the Department of Immigration and Border Protection, we are unable to provide our full names and … titles … However, we believe the evidence that will be submitted will validate the statements that we are making in this submission.” The submission detailed specific allegations – including names and dates – of sexual abuse of child detainees, violence and bullying of children, suicide attempts by children and medical neglect.
(3) There are widespread examples across the US of the police routinely neglecting crimes of sexual violence and refusing to believe victims.
(4) After these two experimental years, a governmental institute for prevention of child abuse and neglect was organized.
(5) The Guardian neglects to mention 150,000 privately owned guns or that Palestinians are banned from bearing arms.
(6) Glutathion and ascorbic acid interfere with the test strip method but this error is neglectable because of physiological low concentrations of these substances.
(7) Chikavu Nyirenda, a leading political analyst, said: "She neglected to look at the local scene but spent a lot of time to please the west and promote herself."
(8) More than half of carers said they were neglecting their own diet as a result of their caring responsibilities, while some said they were eating the wrong things because of the stress they are under and more than half said they had experienced problems with diet and hydration.
(9) During interview and chart audit, the physicians were found to have consistently underestimated, misinterpreted, or neglected psychiatric aspects of care among a majority of patients in the study.
(10) Content-related development issues have been given little attention in the literature, yet their neglect typically results in important limitations on the usefulness of a database.
(11) However, the assessment of acceptance, of existing skills and of the ability of people to learn and absorb computer technology is still a neglected aspect in the implementation of computer systems.
(12) The discrepancy between left versus right latencies increased significantly in the secondary task condition for two patients in the neglect group but not for the other two.
(13) It was shown that neglect of this factor caused regular underestimation of the assessment of medullary doses, patients were exposed to, during x-ray procedures.
(14) But should a traffic officer go to jail for neglecting a dangerous road, or a doctor who misses a critical symptom, or a judge who lets a murderer go free?
(15) A 22 year old female-to-male half-Aboriginal transsexual had been exposed to gross neglect and violence, separation and inconsistent cultural supports during childhood.
(16) Injection of a low dose of haloperidol, that has no obvious behavioral effects in normal mice, produces akinesia, catalepsy, and somatosensory neglect in MPTP-treated mice.
(17) Comparative virology has proved quite productive in a relatively short period, and is unlikely to be neglected in the future.
(18) Patients with unilateral neglect may exhibit slowness in the initiation of contralesionally directed movements in peripersonal space (directional hypokinesia).
(19) One component of the test battery was a simple test described by Albert in which patients cross out lines ruled in a standard fashion on a sheet of paper; this was easy to administer and related closely to neglect diagnosed by the test battery as a whole.
(20) Cut-off points are provided to distinguish between such age-related impairment and visuospatial neglect.