(1) [3H]cyclohexyladenosine (CHA) and [3H]PN200-110 were used to label muscarinic and adenosine A1 receptors and L-type calcium channels, respectively.
(2) Since ADO is a metabolic substrate and a nonselective receptor agonist, while CHA is A1-selective and a poor substrate for cellular uptake, neither A2 activation nor cellular uptake altered expression of the A1 effect of exogenous ADO.
(3) R-PIA, CHA and NECA inhibited contraction in both preparations.
(4) In contrast to the relative consistency of the patterns of 3H-CHA binding in these species, 5'-nucleotidase exhibited wide variations in both the absolute amount of activity and its localization.
(5) Concomitant measurement of [3H]-CHA binding in the mesencephalic reticular formation was also carried out in order to explore the neurochemical basis of the development of tolerance.
(6) For aortic relaxation the analogues exhibited the following rank order of potency: NECA greater than adenosine greater than 2-CA greater than R-PIA greater than CHA.
(7) Regulation of c-fos protooncogene activity in rat embryonal fibroblasts (REF), E1Aad5-immortalized REF cells, and E1Aad5 + cHa-ras transformed REF cells has been investigated.
(8) Although more studies are needed, a recent report of potential utilization of nonstimulated oocytes for donor programs as well as IVF-cryopreservation was a promising new development (Cha et al.
(9) 3H-CHA and 3H-NECA binding sites are concentrated in layers 1-3 and upper layer 5 in the visual cortex of adult cats.
(10) In this paper, CDDP-CHA tried to apply for experimental bone and soft tissue sarcoma.
(11) The effect of toxin on adenosine receptors was also evaluated by measuring binding of the adenosine agonist cyclohexyladenosine (CHA).
(12) "All those vuvuzuelas must be interfering with Cha Bum-Kun's ability to remote control his robot creation - er, son - Cha Du-ri," suggests Angela K, a South Korean expat in the US.
(13) The R(-)- and S(+)-enantiomers of N6-(2-phenylisopropyl)adenosine (R-PIA and S-PIA respectively), N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (CADO) caused contractions at low concentrations (0.05-2.0 microM), whereas at higher concentrations, relaxation resulted.
(14) Circular harmonic averaging (CHA), a novel, reference-independent averaging method developed by W. Kunath and H. Sack-Kongehl [1989) Ultramicroscopy 27:171-184) allows analyzing images of single molecules of the receptor in its native membrane-bound state.
(15) An unexpected finding was that R-PIA, 2-CA and CHA all induced contractions at concentrations lower than were required for relaxation, giving a biphasic dose-response curve.
(16) Concentrations to achieve half-maximum responses were 92.5 nM for 2-ClAdo, 39 nM for CHA, and 107 nM for NECA.
(17) Moreover, the addition of guanylyl-5'-imidodiphosphate, a GTP analogue, to the incubation medium reduced CHA binding by the same order of magnitude whether rats were given saline or bicuculline, suggesting that additional adenosine A1 receptors are also functionally linked to G proteins.
(18) Hippocampi from theophylline-treated animals showed a significantly greater number of [3H]CHA binding sites (apparent Bmax; 125% of control, P less than 0.05), without a significant change in binding affinity, and were more sensitive than controls to the inhibitory effects of adenosine on the population spike response.
(19) Both genes were shown to be present in haploid embryos and have been isolated from a genomic library, the exons and deduced amino acid sequences of which are presented here (salmon CHA and CHB).
(20) Accordingly, the peak in adenosine receptor binding, using (-)[125I]iodo-N6-hydroxyphenyl-isopropyladenosine as the radioligand, coincided with CHA-inhibitable adenylate cyclase activity.
Charming
Definition:
(p. pr. & vb. n.) of Charm
(a.) Pleasing the mind or senses in a high degree; delighting; fascinating; attractive.
Example Sentences:
(1) However, growing accustomed to “this strange atmosphere”, the Observer man became dazzled by Burgess’s “brilliance and charm”.
(2) 133 Hatfield Street, +27 21 462 1430, nineflowers.com The Fritz Hotel Facebook Twitter Pinterest The Fritz is a charming, slightly-faded retreat in a quiet residential street – an oasis of calm yet still in the heart of the city, with the bars and restaurants of Kloof Street five minutes’ walk away.
(3) Song appeared to give Bolt a good luck charm to wear around his wrist.
(4) We all do different things.” She was front and centre at Ashley’s side in footage shot last week by Sky News cameramen, who were also part of the “selected media” entourage invited to Shirebrook to launch the group’s charm offensive.
(5) Bargain of the week Charming but teeny-tiny one-bedroom period cottage, £55,000, with williamsonandhenry.com .
(6) The impressive choice of drinks ranges from local cider to unusual rosés from Navarra and punchy Toro and Bierzo reds, all selected by charming Nubia, wife of Juan Mari.
(7) The crucial additional feature of his nature, however, was that the apparently guileless charm was accompanied by a razor-sharp shrewdness.
(8) I think we are still the underdogs because they have high quality but we will try to do our best – if we lose it’s because Sevilla made a fantastic performance.” As well as missing a penalty Sevilla also hit the woodwork on two occasions, with the Leicester goal living a charmed life at times.
(9) In it he translated Trump’s coarse ramblings into charming straight talk and came up with the phrase “truthful hyperbole”, which captures brilliantly an approach to business and politics in which everything is the greatest, the most beautiful.
(10) For all Lagarde's charm, it's hard not to feel a sense of Alice In Wonderland bewilderment about the IMF's work.
(11) The best charm shows water next to Heaven and then items representing qualities of Air, Earth and Water.
(12) For real will-this-do illustrating, look no further than conjoined twins Tip and Tap , although they admittedly boast a certain erstaz charm not seen post- Pique (the much-maligned Goleo VI and Pille the Erudite Ball apart).
(13) Seth Smith makes the final out of the A's season, which is a good luck charm for the Boston Red Sox, as Smith made the final out for the Colorado Rockies in the 2007 World Series that Boston won.
(14) In the tradition of the American author Patricia Highsmith, creator of the charming psychopath Tom Ripley, Rendell used twisting plots to expose twisted minds.
(15) As to Beyoncé herself, Hamilton had nothing but praise: "She is a very smart, serene lady … utterly charming and focused."
(16) He strikes me more as a clever man - oh, very clever - than a necessarily charming man; for there's a distance, an aloofness.
(17) Lord of the Rings made him the doomed anti-hero , he was easily the best thing in the disastrous Troy, giving Odysseus guile, wit and that familiar, rough-edged charm, and he terrified TV viewers as property developer John Dawson in the dark and brilliant Red Riding .
(18) Pauline Kael, when reviewing the film, said, "Jane Fonda has been a charming, witty, nudie cutie in recent years, and now gets a chance at an archetypal character.
(19) The former Conservative chief whip Andrew Mitchell was a Jekyll and Hyde character who employed a mixture of charm and menace, his libel trial against the Sun newspaper over the Plebgate affair heard.
(20) 5.14pm GMT Alan Pardew speaks ... With a smirk playing around his chops in a charm offensive on Sky Sports, he says he ‘massively regrets” sticking the hid on Hull City midfielder David Meyler and says he’ll be sitting down for matches in the future.